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Małgorzata Gbylik-Sikorska, Anna Gajda, Artur Burmańczuk, Tomasz Grabowski and Andrzej Posyniak

References 1. de Boer V.C., Dihal A.A., van der Woude H., Arts I.C., Wolffram S., Alink G.M., Rietjens I.M., Keijer J., Hollman P.C.: Tissue distribution of quercetin in rats and pigs. J Nutrit 2005, 135, 1718–1725. 2. Chang L., Ren Y., Cao L., Sun Y., Sun Q., Sheng N., Yuan L., Zhi X., Zhang L.: Simultaneous determination and pharmacokinetic study of six flavonoids from Fructus Sophorae extract in rat plasma by LC–MS/MS. J Chrom B 2012, 904, 59–64. 3. Coppin J.P., Xua Y., Chena H., Pan M.H., Hoc Ch.T., Juliani R., Simon J.E., Wu Q

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Yuchi Jia

, phosphonomycin amino butyl alcohol three salt granules, and fosfomycin two sodium salt for injection. Although the clinical application of phosphomycin has increased in recent years, there are few clinical reports in China. According to the related literatures at home and abroad, this review briefly introduces fosfomycin in the following three aspects: progress in synthetic methods, pharmacokinetic and pharmacodynamic characteristics, and antibacterial activities, to provide references for clinical rational use. 2 The synthesis of fosfomycin Fosfomycin was first

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Artur Burmańczuk, Grabowski Tomasz, Małgorzata Gbylik-Sikorska, Anna Gajda and Cezary Kowalski

References 1. Bengtsson B., Jacobsson S.O., Luthman J., Franklin A.: Pharmacokinetics of penicillin-G in ewes and cows in late pregnancy and in early lactation. J Vet Pharmacol Ther 1997, 20, 258–261. 2. Błądek T, Posyniak A, Gajda A, Gbylik M, Żmudzki J.: Multi-class procedure for analysis of antibacterial compounds in animal tissues by liquid chromatography tandem mass spectrometry. Bull Vet Inst Pulawy 2011, 55, 741–748. 3. Bruno F., Curini R., di Corcia A., Nazzari M., Samperi R.: Solid-phase extraction followed by liquid chromatography

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Artur Burmańczuk, Zbigniew Roliński, Cezary Kowalski and Rafał Zań

., Marosevic D., Jaglic Z.: Prevalence of mastitis pathogens in milk from clinically healthy cows. Med Weter 2013, 58, 567–575. 4. Christensen J.M., Smith B.B., Murdena S.B., Hollingshead N.: The disposition of five therapeutically important antimicrobial agents in llamas. J Vet Pharmacol Ther 1996, 19, 43–438. 5. Concordet D., Toutain P.L.: The withdrawal time estimation of veterinary drugs revisited. J Vet Pharmacol Ther 1997, 20, 380–386. 6. Craigmill A.L., Pass M.A., Wetzlich S.: Comparative pharmacokinetics of AMX administered intravenously to sheep

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Anna Gajda, Andrzej Posyniak and Tomasz Błądek

References 1. Anon. U.S. Department of Health and Human Services, Food and Drug Administration (FDA), Center for Drug Evaluation and Research (CDER), Center for Veterinary Medicine: Guidance for Industry, Bioanalytical Method Validation, 2001. 2. Anon. European Medicines Agency (EMEA): Guideline on bioanalytical method validation, 2011. 3. Benchaoui H.A., Nowakowski M., Sherington J., Rowan T.G., Sunderland S.J.: Pharmacokinetics and lung tissue concentrations of tulathromycin in swine. J Vet Pharmacol

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Ioan Țilea, Daniela Saveta Popa, Timea Szakács Xantus, Daniela Primejdie, Bianca Grigorescu, Brîndușa Țilea, Andreea Elena Bocicor and Andreea Varga

.1097/ ALN.0b013e318289bcba 9. Gogarten W, Vandermeulen E, Van Aken H, Kozek S, Llau JV, Samama CM. Regional anesthesia and antithrombotic agents: recommendations of the European society of Anaesthesiology. Eur J Anaesthesiol. 2010 Dec;27(12):999-1015. DOI: 10.1097/ EJA.0b013e32833f6f6f 10. Frost C, Wang J, Nepal S, Schuster A, Barrett YC, Mosqueda-Garcia R, et al. Apixaban, an oral, direct factor Xa inhibitor: single dose safety, pharmacokinetics, pharmacodynamics and food effect in healthy subjects. Br J Clin Pharmacol. 2013 Feb;75

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Anna Gajda, Andrzej Posyniak and Grzegorz Tomczyk

1998, 708, 145-152. 9. Dorrestein G.M., Bruijne J.J.D., Vulto A.: Bioavailability of doxycycline injectable in pigeons. Acta Vet Scand Suppl 1991, 87, 291-292. 10. El-Gendi A.Y.I., Atef M., Amer A.M.M., Kamel G.M.: Pharmacokinetics and tissue distribution of doxycycline in broiler chickens pretreated with either: Diclazuril or halofuginone. Food Chem Toxicology 2010, 48, 3209-3214. 11. EMEA Summary Report Doxycycline (2), European Medicines Agency Veterinary Medicines and Inspections, Committee for Veterinary Medicinal

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Małgorzata Gbylik-Sikorska, Andrzej Posyniak, Tomasz Śniegocki, Bartosz Sell, Anna Gajda, Grzegorz Tomczyk and Jan Żmudzki

1982, 4, 115–135. 10. De Ruyck H., De Ridder H., Van Renterghem R., Van Wambeke F.: Validation of HPLC method of analysis of tetracycline residues in eggs and broiler meat and its application to a feeding trial. Food Addit Contam Part A 1999, 16, 47–56. 11. El-Gendi A.Y., Atef M., Amer A.M., Kamel G.M.: Pharmacokinetic and tissue distribution of doxycycline in broiler chickens pretreated with either: diclazuril or halofuginon. Food Chem Toxicol 2010, 48, 3209–3214. 12. Ershov E., Bellaiche M., Hanji V., Soback S., Gips M., Shlosberg A.: Interaction

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Lidia Radko, Maria Minta, Piotr Jedziniak and Sylwia Stypuła-Trębas

non-clinical toxicity and pharmacokinetics. Acta Trop 2003, 86, 141-159. 10. Delatour P., Benoit E., Besse S., Boukraa A.: Comparative enantioselectivity in the sulphoxidation of albendazole in man, dogs, and rats. Xenobiotica 1991, 21, 217-221. 11. Delatour P., Benoit E., Caude M., Tambute A.: Species differences in the generation of the chiral sulfoxide metabolite of albendazole in sheep and rats. Chirality 1990, 2, 156-160. 12. Delatour P.: Some aspects of the teratogenicity of veterinary drugs. Vet Res Commun 1983

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P. Mudroň

REFERENCES 1. Agwuh, K. N., MacGowan, A., 2006: Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines. J. Antimicrob. Chemotherapy , 58, 256—265. 2. Attebery, J. T., Johnson, H. D., 1969: Effects of environmental temperature, controlled feeding and fasting on rumen motility. J. Anim. Sci. , 29, 734—737. 3. Bengtsson, B., Franklin, A., Luthman, J., Jacobsson, S. O., 1989: Concentrations of sulphadimidine, oxytetracycline and penicillin G in serum, synovial fluid and tissue cage fluid after parenteral