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Exploring sirolimus pharmacokinetic variability using data available from the routine clinical care of renal transplant patients – population pharmacokinetic approach

Introduction Effective immunosuppression plays a crucial role in the successful post-transplantation period. Sirolimus, immunosuppressive which inhibits the cellular response to IL-2 and T-cell proliferation, is approved for the prevention of organ rejection in kidney transplant patients ( 1 , 2 , 3 , 4 ). Sirolimus is characterized by highly variable absorption and elimination which result in substantial blood concentrations differences among patients receiving the same doses ( 5 ). Due to wide intra- and inter-individual pharmacokinetic variability and

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Development of a UHPLC-MS/MS method for the determination of quercetin in milk and its application to a pharmacokinetic study

References 1. de Boer V.C., Dihal A.A., van der Woude H., Arts I.C., Wolffram S., Alink G.M., Rietjens I.M., Keijer J., Hollman P.C.: Tissue distribution of quercetin in rats and pigs. J Nutrit 2005, 135, 1718–1725. 2. Chang L., Ren Y., Cao L., Sun Y., Sun Q., Sheng N., Yuan L., Zhi X., Zhang L.: Simultaneous determination and pharmacokinetic study of six flavonoids from Fructus Sophorae extract in rat plasma by LC–MS/MS. J Chrom B 2012, 904, 59–64. 3. Coppin J.P., Xua Y., Chena H., Pan M.H., Hoc Ch.T., Juliani R., Simon J.E., Wu Q

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Withdrawal of amoxicillin and penicillin G procaine from milk after intramammary administration in dairy cows with mastitis

References 1. Bengtsson B., Jacobsson S.O., Luthman J., Franklin A.: Pharmacokinetics of penicillin-G in ewes and cows in late pregnancy and in early lactation. J Vet Pharmacol Ther 1997, 20, 258–261. 2. Błądek T, Posyniak A, Gajda A, Gbylik M, Żmudzki J.: Multi-class procedure for analysis of antibacterial compounds in animal tissues by liquid chromatography tandem mass spectrometry. Bull Vet Inst Pulawy 2011, 55, 741–748. 3. Bruno F., Curini R., di Corcia A., Nazzari M., Samperi R.: Solid-phase extraction followed by liquid chromatography

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Pharmacokinetic - pharmacodynamic model and ampicillin residue depletion after intramammary administration in cows

., Marosevic D., Jaglic Z.: Prevalence of mastitis pathogens in milk from clinically healthy cows. Med Weter 2013, 58, 567–575. 4. Christensen J.M., Smith B.B., Murdena S.B., Hollingshead N.: The disposition of five therapeutically important antimicrobial agents in llamas. J Vet Pharmacol Ther 1996, 19, 43–438. 5. Concordet D., Toutain P.L.: The withdrawal time estimation of veterinary drugs revisited. J Vet Pharmacol Ther 1997, 20, 380–386. 6. Craigmill A.L., Pass M.A., Wetzlich S.: Comparative pharmacokinetics of AMX administered intravenously to sheep

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Histamine H4 receptor
a Novel Drug Target For Immunoregulation and Inflammation
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Resveratrol and Its Analogues – Is It a New Strategy of Anticancer Therapy?

. Prozdrowotne właściwości resweratrolu, Nauka Technologia Jakość 2011; 5 (78): 5-15. [21] Kumar A, Negi G, Sharma SS. Neuroprotection by resveratrol in diabetic neuropathy: concepts & mechanisms, Curr. Med. Chem. 2013; 20 (36): 4640-5. [22] Lin HS, Ho PC. Preclinical pharmacokinetic evaluation of resveratrol trimethyl ether in Sprague-dawley rats: the impacts of aqeous solubility, dose escalation, food and repeated dosing on oral bioavailability, J. Pharm. Sci. 2011; 100 (10): 4491-500. [23] Liu Yin MY, Wy X, Zeng M, Zhao Q

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Current Biochemical Monitoring and Risk Management of Immunosuppressive Therapy after Transplantation

Initial Immunosuppression Regimen: A National Study. Transpl Int 2016; 29: 1226–36. 9. Shihab F, Christians U, Smith L, Wellen JR, Kaplan B. Focus on mTOR inhibitors and tacrolimus in renal transplantation: pharmacokinetics, exposure-response relationships, and clinical outcomes. Transpl Immunol 2014; 31: 22–32. 10. Brunkhorst LC, Fichtner A, Höcker B, Burmeister G, Ahlenstiel-Grunow T, Krupka K, et al. Efficacy and Safety of an Everolimus- vs. a Mycophenolate Mofetil-Based Regimen in Pediatric Renal Transplant Recipients. PLoS One 2015; 10: e0135439

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Antifungal Azole Metabolites: Significance in Pharmaceutical and Biomedical Analysis

: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in superficial and systemic mycoses. Drugs 1990; 39: 877-916. Goa KL, Barradell LB. Fluconazole: an update of its pharmacodynamic and pharmacokinetic properties and therapeutic use in major superficial and systemic mycoses in immunocompromised patients. Drugs 1995; 50: 658-90. Grant SM, Clissold SP. Itraconazole: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in superficial and

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Liquid Chromatography Metabolite Profiling of Tenofovir Disoproxil Fumarate

References Deeks SG, Bardicht CP, Lietman PS, Hwang F, Cundy KC, Rooney JF, et al. Safety, pharmacokinetics and anti-retroviral activity of intravenous 9-[2-(R)-(phosphonomethoxy)propyl]adenine, a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults. Antimicrob Agents Chemother 1998; 42: 2380-4. Shaw JP, Sueoka CM, Oliyai R, Lee WA, Arimilli KM, Kim CU, et al. Metabolism and pharmacokinetics of novel oral prodrugs of 9-[(R)-2-phosphonomethoxypropyl] adenine (PMPA) in dogs. Pharm

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An LC-MS Assay with Isocratic Separation and On-Line Solid Phase Extraction to Improve the Routine Therapeutic Drug Monitoring of Busulfan in Plasma

-8. 4. Andersson BS, Madden T, Tran HT, Hu WW, Blume KG, Chow DS, et al. Acute safety and pharmacokinetics of intravenous busulfan when used with oral busulfan and cyclophosphamide as pretransplantation conditioning therapy: a phase I study. Biol Blood Marrow Transplant 2000; 6: 548-54. 5. Andersson BS, Thall PF, Madden T, Couriel D, Wang X, Tran HT, et al. Busulfan systemic exposure relative to regimen- related toxicity and acute graft-versus-host disease: defining a therapeutic window for i.v. BuCy2 in chronic myelogenous leukemia. Biol Blood Marrow

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