References Abhilash PC, Singh, N. (2009). Pesticide use and application: An Indian scenario. J Hazard Mater 165: 1-12. Domo Y. (1996). Étude épidémiologique des intoxications aux pesticides dans la province cotonnière du Mouhoun au Burkina Faso, Faculté des Sciences de la Santé. Université de Ouagadougou, Ouagadougou, p. 89. Klaasen CD. (2007). Casarett & Doull’s Toxicology: The Basic Science of Poisons. McGraw-Hill, New York. Konradsen F. (2007). Acute pesticide poisoning - a global public
Adama M. Toe, Mustapha Ouedraogo, Richard Ouedraogo, Sylvain Ilboudo and Pierre I. Guissou
Wasim Aktar, Dwaipayan Sengupta and Ashim Chowdhury
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Rastislav Sabo, Lucia Sabová and Jaroslav Legáth
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Ravindran Jayaraj, Pankajshan Megha and Puthur Sreedev
exposure to persistent organic pollutants. Diabetes Care 34(9): 1972-1979. Aktar MW, Sengupta D, Chowdhury A. (2009). Impact of pesticides use in agriculture: their benefi ts and hazards. Interdisciplinary Toxicology 2(1): 1-12. Arrebola JP, González-Jiménez A, Fornieles-González C, Artacho-Cordón F, Olea N, Escobar-Jiménez F, Fernández-Soto ML. (2015). Relationship between serum concentrations of persistent organic pollutants and markers of insulin resistance in a cohort of women with a history of gestational diabetes mellitus
Marcia H. Ratner, David H. Farb, Josef Ozer, Robert G. Feldman and Raymon Durso
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Islam M. Sadiqul, Saimon Mohiful Kabir, Zannatul Ferdous, Khan Mst. Mansura and Rahman Md. Khalilur
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M. Falis, I. Krupicer, J. Legáth, V. Pitoňák and M. Špalek
 Cox, C. (2000): Glyphosate factsheet. J. Pestic. Reform, 108(3) Retrieved November 24, 2011 from http://www.mindfully.org/Pesticide/Roundup-Glyphosate-Factsheet-Cox.htm  Clough, J. M., Godfrey, C. R. A., Godwin, J. R., Joseph, R. S. I., Spinks, C. (1996): Azoxystrobin: a novel broadspectrum systemic fungicide. Pestic. Outl., 7(4): 16–20  Čerňanská, D., Várady, M., Čorba, J. (2006): A survey on anthelmintic resistance in nematode parasites of sheep in the Slovak Republic. Vet
Manel Araoud, Fadoua Neffeti, Wahiba Douki, Abderraouf Kenani and Mohamed Fadhel Najjar
Background: Human plasma paraoxonase1 (PON1) is an esterase catalyzing the hydrolysis of organophosphorus pesticides and other xenobiotics. The aims of this study were to develop a rapid method to determinate PON1 activity, evaluate some interference, and study the influence of storage temperature on PON1 activity assay.
Methods: Measurement of PON1 activity was performed for 369 samples by measuring the hydrolysis of paraoxon using a spectrophotometric method adapted on konelab 30 ⃞.
Results: The developed method facilitates the determination of PON1 activity at the rate of more than 200 samples per hour, and it is linear between 2 and 900 IU/L. Intra and inter-assay imprecision coefficients of variation were 2% and 5% respectively. PON1 activity in serum was correlated with those in heparinized plasma (r = 0.994, p < 0.001) and in plasma/EDTA (r = 0.962, p < 0.001). The mean inhibition of the PON1 activity was, by EDTA/K3, 41 ± 10 %. There was not significant PON1 activity variation after 40 days of storage at -20°C or at +4 ⃞ C. There were no substantial interferences from haemoglobin, jaundice and hyperlipidemia.
Conclusion: The developed method is reliable, reproducible, and suitable. It can also be performed on heparinized plasma for the determination of PON1 activity. Hence, it may be useful for assaying PON1 activity in several intoxications such as organophosphorus, sarin, and soman nerve agents.
The Journal of Institute of Experimental Pharmacology of Slovak Academy of Sciences
Henshaw Uchechi Okoroiwu and Iwara Arikpo Iwara
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