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Adama M. Toe, Mustapha Ouedraogo, Richard Ouedraogo, Sylvain Ilboudo and Pierre I. Guissou

References Abhilash PC, Singh, N. (2009). Pesticide use and application: An Indian scenario. J Hazard Mater 165: 1-12. Domo Y. (1996). Étude épidémiologique des intoxications aux pesticides dans la province cotonnière du Mouhoun au Burkina Faso, Faculté des Sciences de la Santé. Université de Ouagadougou, Ouagadougou, p. 89. Klaasen CD. (2007). Casarett & Doull’s Toxicology: The Basic Science of Poisons. McGraw-Hill, New York. Konradsen F. (2007). Acute pesticide poisoning - a global public

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Wasim Aktar, Dwaipayan Sengupta and Ashim Chowdhury

References Altenbach JS, Geluso KN and Wilson DE. (1979). Population size of Tadaria brasiliensis at Carlsbad Caverns in 1973. In: Grnoways HH and Baker RJ (eds) Biological investigations in Guadelupe Mountains National Park, Texas. Natl Park Service Proc Trans Ser No 4: 341. Ambrosi D, Isensee A and Macchia J. (1978). Distribution of oxadiazon and phoslone in an aquatic model ecosystem. American Chem Soci   26(1) : 50-53. Andreu V, Pico' Y. (2004). Determination of pesticides

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Rastislav Sabo, Lucia Sabová and Jaroslav Legáth

. Elandalloussi LM, Rodrigues PM, Afonso R, Leite RB, Nunes PA, Cancela ML. (2005). Shikimate and folate pathways in the protozoan parasite, Perkinsus olseni. Mol Biochem Parasitol   142 : 106-109. Hronec O, Tóth J and Tomáš J. (2002). Cudzorodé látky a ich riziká. Harlequin Ltd., Košice, ISBN 80-968824-0-6, 200 pp. Karabelas AJ, Plakas KV, Solomou ES, Drossou V, Sarigiannis DA. (2009). Impact of European legislation on marketed pesticides - a view from the standpoint of health impact assessment studies. Environ Int   35

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Ravindran Jayaraj, Pankajshan Megha and Puthur Sreedev

exposure to persistent organic pollutants. Diabetes Care 34(9): 1972-1979. Aktar MW, Sengupta D, Chowdhury A. (2009). Impact of pesticides use in agriculture: their benefi ts and hazards. Interdisciplinary Toxicology 2(1): 1-12. Arrebola JP, González-Jiménez A, Fornieles-González C, Artacho-Cordón F, Olea N, Escobar-Jiménez F, Fernández-Soto ML. (2015). Relationship between serum concentrations of persistent organic pollutants and markers of insulin resistance in a cohort of women with a history of gestational diabetes mellitus

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Marcia H. Ratner, David H. Farb, Josef Ozer, Robert G. Feldman and Raymon Durso

References Ahmadi A, Fredrikson M, Jerregard H, Akerback A, Fall PA, Rannug A, Axelson O, Soderkvist P. (2000). GSTM1 and mEPHX polymorphisms in Parkinson’s disease and age of onset. Biochem Biophysiol Res Comm 269(3): 676-680. Andersen JK (2003) Paraquat and iron exposure as possible synergistic environmental risk factors in Parkinson’s disease. Neurotoxicol Res 5(5): 307-313. Ascherio A, Chen H, Weisskopf MG, O’reilly E, McCullough ML, Calle EE, Schwarzschild MA, Thun MJ. (2006). Pesticide exposure and risk

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Islam M. Sadiqul, Saimon Mohiful Kabir, Zannatul Ferdous, Khan Mst. Mansura and Rahman Md. Khalilur

European minnow Phoxinus phoxinus and mollie Poecilia latipinna : an assessment of the fish micronucleus test. Mut Res 467 : 177–186. Barsiene JV, Dedonyt E, Rybakovas A, Andreikenaite L, Andersen OK. (2006). Investigation of micronuclei and other nuclear abnormalities in peripheral blood and kidney of marine fish treated with crude oil. Aquat Toxicol 78 : S99–S104. Behrends A, Hardeland R, Ness H, Grube S, Poeggeler B, Haldar C. (2004). Photocatalytic actions of the pesticide metabolite 2-hydroxyquinoxaline: destruction of antioxidant vitamins and

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M. Falis, I. Krupicer, J. Legáth, V. Pitoňák and M. Špalek

[1] Cox, C. (2000): Glyphosate factsheet. J. Pestic. Reform, 108(3) Retrieved November 24, 2011 from http://www.mindfully.org/Pesticide/Roundup-Glyphosate-Factsheet-Cox.htm [2] Clough, J. M., Godfrey, C. R. A., Godwin, J. R., Joseph, R. S. I., Spinks, C. (1996): Azoxystrobin: a novel broadspectrum systemic fungicide. Pestic. Outl., 7(4): 16–20 [3] Čerňanská, D., Várady, M., Čorba, J. (2006): A survey on anthelmintic resistance in nematode parasites of sheep in the Slovak Republic. Vet

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Manel Araoud, Fadoua Neffeti, Wahiba Douki, Abderraouf Kenani and Mohamed Fadhel Najjar

Abstract

Background: Human plasma paraoxonase1 (PON1) is an esterase catalyzing the hydrolysis of organophosphorus pesticides and other xenobiotics. The aims of this study were to develop a rapid method to determinate PON1 activity, evaluate some interference, and study the influence of storage temperature on PON1 activity assay.

Methods: Measurement of PON1 activity was performed for 369 samples by measuring the hydrolysis of paraoxon using a spectrophotometric method adapted on konelab 30 ⃞.

Results: The developed method facilitates the determination of PON1 activity at the rate of more than 200 samples per hour, and it is linear between 2 and 900 IU/L. Intra and inter-assay imprecision coefficients of variation were 2% and 5% respectively. PON1 activity in serum was correlated with those in heparinized plasma (r = 0.994, p < 0.001) and in plasma/EDTA (r = 0.962, p < 0.001). The mean inhibition of the PON1 activity was, by EDTA/K3, 41 ± 10 %. There was not significant PON1 activity variation after 40 days of storage at -20°C or at +4 ⃞ C. There were no substantial interferences from haemoglobin, jaundice and hyperlipidemia.

Conclusion: The developed method is reliable, reproducible, and suitable. It can also be performed on heparinized plasma for the determination of PON1 activity. Hence, it may be useful for assaying PON1 activity in several intoxications such as organophosphorus, sarin, and soman nerve agents.

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Interdisciplinary Toxicology

The Journal of Institute of Experimental Pharmacology of Slovak Academy of Sciences

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Henshaw Uchechi Okoroiwu and Iwara Arikpo Iwara

REFERENCES Aditya S, Willayat YN, Deep RS, Kiran DG. (2012). Dichlorvos exposure results in activation induced apoptic cell death in primary rat microglia. Chem Res Toxicol 25 (8): 1762–70. APVMA: Australian Pesticides and veterinary Medicine Authority (2011), Dichlorvos final review report and regulatory decision . Kingston Act: APVMA. Pp. 1–114. APVMA: Australian Pesticides and Veterinary Medicines Authority (2008). Dichlorvos: Environmental assessment APVMA . Kingston Act 2604, Australia. Pp. 1–71. ATSDR: Agency for Toxic Substance