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Human therapeutic cloning, pitfalls and lack luster because of rapid developments in induced pluripotent stem cell technology

:989-92. 4. Hochedlinger K, Jaenisch R. Nuclear transplantation, embryonic stem cells, and the potential for cell therapy. N Engl J Med. 2003; 349:275-96. 5. Eggan K, Baldwin K, Tackett M, Osborne J, Gogos J, Chess A, et al. Mice cloned from olfactory sensory neurons. Nature 2004; 428:44-9. 6. Li J, Ishii T, Feinstein P, Mombaerts P. Odorant receptor gene choice is reset by nuclear transfer from mouse olfactory sensory neurons. Nature. 2004; 428:393-9. 7. Brambrink T, Hochedlinger K, Bell G, Jaenisch R. ES cells derived from

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Relationship between vitamin D receptor gene polymorphisms and anemia in postmenopausal Vietnamese women

-directed mutagenesis define the key points of interaction between the ligand-binding domain of the vitamin D nuclear receptor and 1R,25-dihydroxyvitamin. Biochemistry. 2000; 39:12162-71. 5. Bhanushali AA, Lajpal N, Kulkarni SS, Chavan SS, Bagadi SS, Das BR. Frequency of fokI and taqI polymorphism of vitamin D receptor gene in Indian population and its association with 25-hydroxyvitamin D levels. Indian J Hum Genet. 2009; 15:108-13. 6. Uitterlinden AG, Fang Y, van Meurs JB, Pols HA, Van Leeuwen JP. Genetics and biology of vitamin D receptor

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Foreign medical practitioners: requirements for medical practice and postgraduate training in Thailand under ASEAN Economic Community liberalization in 2015

) psychiatry, (2) child and adolescent psychiatry, (3) forensic medicine, (4) anatomical pathology, (5) clinical pathology, (6) general pathology, (7) therapeutic radiology and oncology, (8) family medicine, (9) emergency medicine, (10) nuclear medicine, (11) oncology, and (12) hematology. Internship experience is not required for application in these fields and applicants in this category can begin their training as early as the year following graduation. The duration of training is normally 3 years, except for 4-year training programs in child and adolescent psychiatry

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Comparison of methods for deriving neural progenitor cells from nonhuman primate embryonic stem cells

) Nuclear receptor tailless (TLX) expression was measured by qRT-PCR in neural cells differentiated from feeder-free derived NPCs (n = 3, P < 0.05). The expression of GFAP is related to TLX expression in rhNPC Several studies reported that the nuclear receptor tailless (TLX) plays an important role in vertebrate brain functions [ 16 , 17 ]. TLX belongs to the nuclear receptor, NE2E orphan nuclear receptor family. TLX is expressed in the neuroepithelium of developing central nervous system [ 16 ] and acts as a repressor of cell cycle inhibitors to maintain the

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Inhibition of cell cycle progression and apoptotic activity of resveratrol in human intrahepatic cholangiocarcinoma cell lines

:193-9. 32. Jin P, Hardy S, Morgan DO. Nuclear localization of cyclin B1 controls mitotic entry after DNA damage. J Cell Biol. 1998; 141:875-85. 33. Surh YJ, Hurh YJ, Kang JY, Lee E, Kong G, Lee SJ. Resveratrol, an antioxidant present in red wine, induces apoptosis in human promyelocytic leukemia (HL-60) cells. Cancer Lett. 1999; 140:1-10. 34. Bras M, Queenan B, Susin SA. Programmed cell death via mitochondria: different modes of dying. Biochemistry (Mosc). 2005; 70:231-9. 35. Cande C, Cecconi F, Dessen P, Kroemer G

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Analysis in silico of the single nucleotide polymorphism G–152A in the promoter of the angiotensinogen gene of Indonesian patients with essential hypertension

by hypoxia through recruitment of HIF-1 [ 11 ]. HIF-1 is a heterodimeric transcription factor that is composed of 2 different subunits, HIF-1a and aryl receptor nuclear translocator (ARNT). There are 826 and 789 amino acids in the 2 subunits, respectively. Both of these subunits belong to the basic helix–loop–helix (bHLH) Per–Ahr/Arnt–Sim family, where Per is the period circadian protein, Ahr/Anrt the aryl hydrocarbon receptor nuclear translocator protein, and Sim the single-minded protein domain. The bHLH domain is responsible for dimerization through 2 helices

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Soluble lectin-like oxidized low density lipoprotein receptor-1 in metabolic syndrome

diagnosis of metabolic syndrome [ 2 ], while the National Cholesterol and Education Program Adult Treatment Panel III (NCEP-ATP III), American Association of Clinical Endocrinology, and International Diabetes Federation (IDF) adopted abdominal obesity as pivotal [ 3 - 6 ]. However, the core components of the metabolic syndrome, which include dyslipidemia, impaired glucose tolerance, increased waist circumference and hypertension, are classical risk factors required for diagnosis [ 7 ]. The lectin-like oxidized low density lipoprotein receptor (LOX-1) is a receptor for

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Incidence and risk factors for adverse events during anesthesiologist-led sedation or anesthesia for diagnostic imaging in children: a prospective, observational cohort study

Computed tomography (CT), magnetic resonance imaging (MRI), and nuclear medicine imaging have become routine in diagnostic clinical practice. They are often noninvasive and not painful; however, patients need to be able to lie still for the duration of image acquisition. This may be particularly challenging in children. Techniques such as sleep deprivation [ 1 ], feed and sleep/wrap [ 2 ], play therapy [ 3 ], administration of melatonin [ 4 ], and parental involvement can make some children more cooperative, but sedation remains the most reliable means of

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Phthalate exposure in Thai children and adolescents

. Chromatographic data were acquired and processed using Chromeleon software (Thermo Fisher Scientific). A Sepex GP-C18 column (1.8 μm, 2.1 mm Ø × 100 mm) was used for chromatographic separation of phthalates. The mobile phase consisted of acetonitrile-acetic acid (99.9/0.1, v/v) and water, which were designated as A and B, respectively [ 30 ]. The gradient elution program was as follows: from 0 to 5 min, 30% A; linear increase to 90% A, from 5 to 7 min; linear decrease to 30% A; and, stabilization at initial condition (30% A, 70% B) for 3 min. The flow rate was 0.4 mL/min, the

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Perioperative insulin therapy

A Macrae D Pathan N Cardioprotective effects of insulin: how intensive insulin therapy may benefit cardiac surgery patients Circulation 2012 125 721 – 8 [14] Chaudhuri A, Dandona P, Fonseca V. Cardiovascular benefits of exogenous insulin. J Clin Endocrinol Metab. 2012; 97:3079–91. 10.1210/jc.2012-1112 Chaudhuri A Dandona P Fonseca V Cardiovascular benefits of exogenous insulin J Clin Endocrinol Metab 2012 97 3079 – 91 [15] Dandona P, Aljada A, Mohanty P, Ghanim H, Hamouda W, Assian E, Ahmad S. Insulin inhibits intranuclear nuclear

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