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Zvonka Slavec, Simona Gaberscek and Ksenija Slavec

. Kocijančič A, Mrevlje F.(ed.). Interna medicina . (Internal medicine), Ljubljana: EWO, DZS; 1993. 1145 pages. Avsec Letonja D, Vončina J. Transplantacijska dejavnost: donorski program. 1, Organi . (Transplant activity - a donor programme). Ljubljana: Zavod RS za presaditev organov in tkiv Slovenija-transplant; 2003. 146 pages. Hodolic M. Role of (18)F-choline PET/CT in evaluation of patients with prostate carcinoma. Radiol Oncol 2011; 45 : 17-21.

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Bozidar Casar, Maria do Carmo Lopes, Advan Drljević, Eduard Gershkevitsh and Csilla Pesznyak

medicine examinations and 5 million radiotherapy courses undertaken annually. Such tremendous development has triggered demands and need for more highly educated and well trained medical physicists. Introduction of formal systems for education and clinical training became crucial and many universities in Europe offer academic programmes in medical physics. However, there is still a lack of accredited clinical training programs in the majority of countries in Europe. Although international and European professional medical physics organizations together with European

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Bartlomiej Szynglarewicz, Piotr Kasprzak, Przemyslaw Biecek, Agnieszka Halon and Rafal Matkowski

Introduction The development of imaging techniques and the widespread adoption of screening programs resulted in dramatically increased incidence of ductal carcinoma in situ (DCIS), which currently accounts for about 20 – 25% of newly diagnosed breast cancer cases. 1 The most common clinical presentation of DCIS are mammographically visible microcalcifications. Although being present in about 30% of all breast cancers and in approximately 55% of non-palpable breast malignancies, they are responsible for the detection of 85 – 95% of cases of DCIS by

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Tanja Mesti, Nadia Bouchemal, Claire Banissi, Mohamed N. Triba, Carole Marbeuf-Gueye, Maja Cemazar, Laurence Le Moyec, Antoine F. Carpentier, Philippe Savarin and Janja Ocvirk

-Herttuala S, et al. Assignment of 1H nuclear magnetic resonance visible polyunsaturated fatty acids in BT4C gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death. Cancer Res 2003; 63: 3195-201. Griffin JL Lehtimäki KK Valonen PK Gröhn OH Kettunen MI Ylä-Herttuala S et al Assignment of 1H nuclear magnetic resonance visible polyunsaturated fatty acids in BT4C gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death Cancer Res 2003 63 3195 201 26 Opstad KS, Bell BA

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Alexandru Florin Rogobete, Ovidiu Horea Bedreag, Sonia Elena Popovici, Adriana Mariana Sas, Adrian Tudor Stan, Emil Robert Stoicescu and Dorel Sandesc

Critically Ill Polytrauma Patients. Clin Lab. 2016;8:1-7. doi: 10.7754/Clin.Lab.2016.160121. 12. Abdelmohsen K, Srikantan S, Kang M-J, Gorospe M. Regulation of senescence by microRNA biogenesis factors. Ageing Res Rev. 2012;11:491-500. doi: 10.1016/j.arr.2012.01.003. 13. Papurica M, Rogobete AF, Sandesc D, et al. The Expression of Nuclear Transcription Factor Kappa B (NF-KB) in the Case of Critically Ill Polytrauma Patients with Sepsis and Its Interactions with microRNAs. Biochem Genet. 2016;54:337–347. doi: 10.1007/s10528-016-9727-z. 14. Bedreag OH

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Natale Quartuccio, Giorgio Treglia, Marco Salsano, Maria Vittoria Mattoli, Barbara Muoio, Arnoldo Piccardo, Egesta Lopci and Angelina Cistaro

References 1. Mirabello L, Troisi RJ, Savage SA. Osteosarcoma incidence and survival rates from 1973 to 2004: data from the Surveillance, Epidemiology, and End Results Program. Cancer 2009; 115: 1531-43. 2. Ritter J, Bielack SS. Osteosarcoma. Ann Oncol 2010; 21: 320-5. 3. Arndt CA, Crist WM. Common musculoskeletal tumors of childhood and adolescence. N Engl J Med 1999; 341: 342-52. 4. Bielack SS, Kempf-Bielack B, Delling G, Exner GU, Flege S, Helmke K, et al. Prognostic

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Mahdi Ghorbani, Benyamin Khajetash, Najmeh Ghatei, Mohammad Mehrpouyan, Ali S. Meigooni and Ramin Shahraini

method is based on random sampling to achieve the required results. Different Monte Carlo codes are currently used in medical radiation physics: MCNP, EGSnrc, GEANT4, SIMIND, etc. Monte Carlo N-Particle (MCNP) is specially designed for nuclear application of radiation transport but it also can be used for other fields, for example in medical physics applications. Monte Carlo codes are of high capabilities in particle transport physics lacking applications in practical medical physics dosimetric problems. 12 - 14 These methods can have desired results to assess

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Jakob Liermann, Patrick Naumann, Franco Fortunato, Thomas E. Schmid, Klaus-Josef Weber, Jürgen Debus and Stephanie E. Combs

ponicidin have been published. 6 , 7 , 8 In pancreatic cancer oridonin induces apoptosis and leads to an arrest in the G2/M-phase of the cell cycle. 9 , 10 , 11 , 12 Further, oridonin inhibits nuclear factor-kB. 13 Ponicidin is also known to induce apoptosis 14 , 15 , 16 , 17 but to our knowledge, there is no data for ponicidin in pancreatic cancer. Potential radiosensitization could be observed in chinese-hamster-V79 cells by oridonin. 18 Apart from this study we found no publication concerning oridonin or ponicidin induced radiomodulation. As natural occurring

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Erna Alukic, Damijan Skrk and Nejc Mekis

effective dose was calculated using the Monte Carlo simulation program PCXMC 2.0 (STUK, Radiation and Nuclear Safety Authority in Finland). The image field size, weight and height were inserted into the program for each patient individually. The effective dose calculations were then performed for each patient according to the Monte Carlo simulation and the measured DAP value. Statistical analysis All the measurements were processed with the IBM SPSS STATISTICS version 23. Shapiro-Wilk test was used to check the normal distribution of the sample. For the phantom

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Martina Vrankar and Karmen Stanic

affect others mediators and mechanisms that contribute to immune cell death, such as production of type I interferon which is necessary for DC activation, calreticullin translocation, release of nuclear protein high-mobility group box-1 (HMGB1) and adenosine triphosphate (ATP). 28 Other mediators of immune response enhanced by radiation are major histocompatibility complex (MHC) class I and Fas surface expression that induces programmed cell death. 29 Radiation also increases the density of tumour-infiltrating lymphocytes. The mechanism is probable multifactorial