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domain. PIP 3 : Phosphatidylinositol 3,4,5-triphosphate. PKC: Protein kinase C. Lyn, Syk: Src-family tyrosine kinases. BLNK: B-cell linker protein. PLCγ2: Phospholipase C γ-2. NF-κB: Nuclear factor kappa B.
Btk contains five domains through which it interacts with other proteins of the B-cell receptor signalling pathway, leading to PLCγ2 and eventually, NF-κB activation. PH is used for binding to PIP 3 , which recruits Btk to the plasma membrane; TH contains a zinc-finger motif; SH2 is used for docking to phosphorylated tyrosine residues on other proteins, allowing
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poor responders’ osteosarcoma including immunomodulation. Improvements in clinical outcomes may largely been attributable to a multidisciplinary team-based approach consequently at 2014, a multidisciplinary teamwork (paediatrician, orthopaedic surgeon, and nuclear medicine physician) evolved and finally succeeded in establishment of a weekly multidisciplinary solid tumour clinic at Paediatric haematology/ oncology clinic to improve the management and outcome of paediatric bone tumour through better communication and rapid decisions. Furthermore in the developing
’S BELIEFS AND ATTITUDES IN THE PREFECTURE OF SERRES TOWARDS BREAST CANCER SCREENING USING THE HEALTH BELIEF MODEL
Tragouda S. 1 , Trigoni M. 2 , Paraskeuopoulou S. 3
1 . Post-graduate student of the Healthcare Management post-graduate studies program (Hellenic Open University)
2 . Head of Department of Social Services University Hospital of Crete, Consultant Professor of Hellenic Open University, Greece
3 . Consultant Professor of Hellenic Open University, Greece
Introduction : Breast cancer is the most common form of neoplasm in women and the most frequently
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