Hepatitis E virus (HEV) is transmitted mainly through food and water sources. HEV is a major public health problem faced by developing countries. HEV causes large outbreaks of hepatitis E (HE) or acute sporadic infection. HEV can also lead to chronic infection. HEV mainly affects the young, middle-aged people, and pregnant women, who especially display high rates of infection. This study reviews HE while considering its biological characteristics, clinical symptoms, epidemic characteristics, vaccine, and detection methods.