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Shumin Lan, Jingming Lin and Ni Zheng

triterpenes oleanolic and ursolic acids and application to Swertia species: optimization of triterpenic acids extraction and pre-column derivatization using response surface methodology, Anal. Chim. Acta 688 (2011) 208-218; DOI: 10.1016/j.aca.2011.01.010. 5. Y. Li, J. G. Jiang, W. F. Li, C. Jian, D. Y. Wang and L. Zhu, Optimum extraction process of polyphenols from the bark of Phyllanthus emblica L. based on the response surface methodology, J. Sep. Sci. 32 (2009) 1437-1444; DOI: 10.1002/jssc.200800744. 6. A. X. Luo, X. J. He, S. D. Zhou, Y

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Hagalavadi Shivakumar, Pragnesh Patel, Bapusaheb Desai, Purnima Ashok and Sinnathambi Arulmozhi

. K. P. R. Chowdary and Y. S. Rao, Design and in vitro and in vivo evaluation of mucoadesive microcapsules of glipizide for oral controlled release, AAPS Pharm. Sci. Tech. 4 (2003) 1--6; DOI: 10.1208/pt 0040339. G. A. Lewis, D. Mathieu and R. Phan Tan Lui, Response Surface Methodology , in Pharmaceutical Experimental Design , Marcel Dekker, New York 1999, pp. 185--246. P. J. Sinko, Micromeritics in Martin's Physical Pharmacy and Pharmaceutical Sciences (Ed. P. J. Sinko), 5 th ed., Williams & Wilkins

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Muhammad Hanif, Hafeez Ullah Khan, Samina Afzal, Asif Mahmood, Safirah Maheen, Khurram Afzal, Nabila Iqbal, Mehwish Andleeb and Nazar Abbas

. Narendra, M. S. Srinath and R. Prakash, Development of a three layered buccal compact containing metoprolol tartrate by statistical optimization technique, Int. J. Pharm. 304 (2005) 102-114; 24. B. C. Nandy and B. Mazumder, Formulation and characterizations of delayed release multi-particulates system of indomethacin: optimization by response surface methodology, Curr. Drug Deliv. 10 (2014) 72-86; 25. D. V. Gowda and H. G. Shivakumar, Preparation and

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Bhupinder Singh, Sonia Pahuja, Rishi Kapil and Naveen Ahuja

References Y. W. Chien, Rate-control drug delivery systems: Controlled release vs. sustained release, Med. Prog. Technol.   15 (1989) 21-46. Y. Song, Y. Wang, R. Thakur, V. M. Meidan and B. Michniak, Mucosal drug delivery: membranes, methodologies, and applications, Crit. Rev. Ther. Drug Carrier Syst.   21 (2004) 195-256; DOI: 10.1615/CritRevTherDrugCarrierSyst.v21.i3.20. B. Singh, S. K. Chakkal and N. Ahuja, Formulation and optimization of controlled release mucoadhesive

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Pradeep Kumar and Inderbir Singh

. Ahuja, Formulation and optimization of controlled release mucoadhesive tablets of atenolol using response surface methodology, AAPS PharmSciTech   7 (2006) E1-E10; DOI: 10.1208/pt070103. B. Singh, R. Kumar and N. Ahuja, Optimizing drug delivery systems using systematic "design of experiments". Part I: fundamental aspects, Crit. Rev. Ther. Drug Carrier Syst.   22 (2005) 27-105; DOI: 10.1615/CritRevTherDrugCarrierSyst.v22.i1. N. A. Peppas and N. M. Franson, The swelling interface number as a criterion for

Open access

Venkata Srikanth Meka, Chew Ee Li and Ravi Sheshala

.2298/ciceq0801017n. 22. K. K. Satish, K. P. Santhosh, K. N. Nishanth and B. P. Bharghav, Formulation and in vitro evaluation of ofloxacin tablets, J. Pharm. Res . 4 (2011) 3007. 23. R. H. Myers, D. C. Montgomery and C. M. A. Cook, Response Surface Methodology: Process and Product Optimization Using Designed Experiments, 3 rd ed., Wiley, New York 2009, pp. 15–29. 24. V. S. Meka, N. S. Rao, S. A. Sunil, B. J. Ram and K. V. R. Murthy, Thermal sintering: a novel technique used in the design, optimization and biopharmaceutical evaluation of propranolol

Open access

Simon Kukec, Franc Vrečer and Rok Dreu

The objective of this work was to investigate the influence of selected individual variables (binder content, inlet air temperature, and product endpoint temperature) of in situ fluid bed melt granulation on the granule particle size distribution and percentage of dissolved carvedilol using a three-factor, five-level circumscribed central composite design. Increased binder content had the effect of increasing the granule particle size and drug dissolution rate. The effect of inlet air temperature and product endpoint temperature was found to be more pronounced in case of granule particle size parameters. Within the studied intervals, the optimal quantity of binder as well as optimal process parameters were identified and validated using response surface methodology. Utilizing these optimal process and formulation parameters, successful scaling up of the fluid bed melt granulation process was carried out. Granule characteristics obtained at pilot scale are comparable to those obtained at laboratory scale.

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Dalwadi Sonali, Soni Tejal, Thakkar Vaishali and Gandhi Tejal

) 47-60; DOI: 10.1016/S0939-6411(00)00076-X. Y. Rane, R. Mashru, M. Sankalia and J. Sankalia, Effect of hydrophilic swellable polymers on dissolution enhancement of carbamazepine solid dispersions studied using response surface methodology, AAPS Pharm. Sci. Tech.   8 (2007) Article 27; DOI: 10.1208/pt0802027. A. Avani and M. Renuka, Formulation development of taste-masked rapidly dissolving films of cetirizine hydrochloride, Pharm. Tech.   33 (2009) 48-56. S. J. Hwang, D. H. Won, M. S

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Ajit A. Patil, Sachin S. Bhusari, Devanand B. Shinde and Pravin S. Wakte

: Schum and Thonn growing at different altitudes, J. Med. Plants Res . 4 (2010) 41-48. 23. International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use, ICH Harmonised Tripartite Guideline, Validation of Analytical Procedures: Text and Methodology Q2(R1) , Current Step 4 version, Geneva, November 2005;; last access date February 1, 2012 24. D. C. Montgomery, Design and

Open access

Amit Nayak, Bibek Laha and Kalyan Sen

References D. R. Dirschl and L. C. Almekinders, Osteomyelitis. Common causes and treatment recommendations, Drugs   45 (1993) 29-43. J. T. Mader, G. C. Landon and J. H. Calhoun, Antimicrobial treatment of osteomyelitis, Clin. Orthop.   295 (1993) 87-95. A. K. Nayak, Hydroxyapatite synthesis methodologies: An overview, Int. J. ChemTechRes.   2 (2010) 903-907. D.-S. Park, I.-S. Kim, H. Kim, A. H. Chou, B.-D. Hahn, L.-H. Li and S.-J. Hwang, Improved