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Silviya S. Aleksandrova-Yankulovska

analysis and application of methodology for decision-making in clinical practice [dissertation]. Pleven: MU-Pleven; 2015. [Bulgarian] 5. Prodanov V. Boiethics [Internet]. Sofi a: Science and Art; 1988:253. Available in Bulgarian from: http:// 6. Bulgarian Health Act. Promulgated, State Gazette No. 70/10.08.2004. 7. Law of medicinal products. Promulgated, State Gazette No. 31/13.04.2007. 8. Department of ethical studies. Institute for the study of

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Andriana Bukonjić and Srđan Stefanović

of urology: Incidence and patterns of antibiotic resistance. Scand J Urol. 2013. Epub ahead of print 8. World Health Organization Collaborating Centre for Drug Statistics Methodology. About the ATC/DDD system. (Available at: Accessed 1.12. 2013). 9. Pešić G, Jović Z, Vasić K. Primena ATC/DDD metodologije pri upoređivanju upotrebe antibiotika u toku dvomesečnog perioda u dvema hirurškim bolnicama. Acta Facultatis Medicae Naissensis. 2006; 23(1): 39-44. 10. Radonjić V, Đukić L

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Dejan Aleksic, Andriana Bukonjic and Srdjan Stefanovic

and costs associated with nonsteroidal antiinflammatory drugs versus acetaminophen: retrospective cohort study of an elderly population. Arthritis Rheum. 2000; 43(4): 917-24. 11. Bloom SB. Direct medical costs of disease and gastrointestinal side effects during treatment for arthritis. Am J Med 1986; 84 (Suppl 2A): 20-4. 12. World Health Organization Collaborating Centre for Drug Statistics Methodology. About the ATC/DDD system. Available at: Accessed 1.10.2013. 13. Sweetman SC, ed. Martindale: the complete drug

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Folia Medica

The Journal of Medical University-Plovdiv

Open access

Alexandru Robert Vlad, Gabriel Hancu, Hajnal Kelemen, Diana Ciurcă and Amelia Tero-Vescan


Sibutramine is a chiral anti-obesity drug which decreases food intake and increases energy expenditure. In therapy it is used as a racemic mixture; however both pharmacokinetic and pharmacodynamic data have revealed enantioselective behavior of sibutramine and its major active metabolites. Several chromatographic and electrophoretic analytical methods have been published so far for the chiral determination of sibutramine from pharmaceutical preparations and biological samples. The current paper aims to provide a systematic review of the stereochemical aspects and analytical methods used for the enantiodetermination of sibutramine and its active enantiomers covering the last 15 years.

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Cesare Faldini, Domenico Fenga, Ilaria Sanzarello, Matteo Nanni, Francesco Traina and Michele Attilio A. Rosa


Background: Clubfoot is one of the most common congenital limb deformities. Prenatal diagnosis of the condition is essential as it can help treat the malformation as early as possible. We reviewed the recent available literature concerning the current methods for prenatal diagnosis of clubfoot.

Methods: The following databases were searched from 1966 to 2015: PubMed, OVID, Cochrane, CINAHL, Google scholar and Embase.

Results: Out of a total number of 197 retrieved articles, after abstract or title page evaluation, 158 articles not matching the inclusion criteria were excluded. The full text versions of the remaining 39 articles were obtained, and their reference lists screened, with the addition of another 5 full-text articles.

Conclusions: Currently, ultrasonography is considered the most reliable method of prenatal diagnosis of clubfoot. Ultrasonographic diagnosis of clubfoot appears more likely between the 18th and the 24th week of pregnancy. Alternative imaging is not indicated. There is no agreement whether to propose foetal karyotyping when isolated clubfoot is diagnosed by prenatal ultrasonography. Early detection of clubfoot should prompt a careful surveillance during pregnancy in order to detect any possible additional abnormalities and, if any of these are detected, invasive testing should be offered.

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Formulation in Action

Applying Psychological Theory to Clinical Practice

David Dawson and Nima Moghaddam

Open access

Ashok Sharmila, Saiby Madan and Kajri Srivastava

and Computation 243 (2014) 209–219 4. WHO. Media Centre, Epilepsy, Fact Sheet. < > (accessed 2013). 5. NINDS. Seizure and Epilepsy: Hope Through Research. National Institute of Neurological Disorders Available from: < >. (accessed 2013). 6. S.G. Dastidar, H. Adeli, N. Dadmehr, Mixed band wavelet- chaos-neural network methodology for epilepsy and epileptic seizure detection, IEEE Trans. Biomed. Eng. 54 (9) (2007) 1545–1551. 7. H

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Abbas Heydari, Seyed Majid Vafaei and Mahmoud Bakhshi

Utilization among Iranian Nurses: a Literature Review. J Caring Sci 2014;3(4):265-75. 5. Gioia DA, Corley KG, Hamilton AL. Seeking qualitative rigor in inductive research notes on the Gioia methodology. Organ Res Methods 2013; 16(1):15-31. 6. Balazs CL, Morello FR. The three Rs: How community-based participatory research strengthens the rigor, relevance, and reach of science. Environ Justice 2013;6(1). 9-16. 7. Truluck CA, Leggett T. Critical Appraisal of Health Professions

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Diana P. Karcheva-Bahchevanska, Paolina K. Lukova, Mariana M. Nikolova, Rumen D. Mladenov and Ilia N. Iliev

Asspergilus terreus on α-glucosidase activity and postprandial hyperglycemia. Pak J Biol Sci 2007;10(8):3131-35. 15. Hall CA, Cuppet SL. Structure-activities of natural antioxidants. In: Aruoma OI, Cuppett SL, eds. Antioxidant Methodology: in Vivo and in Vitro Concepts. Champaign, IL USA:AOCS Press;1997:141-72. 16. Adeniran HA, Abiose SH, Ogunsua AO. Production of fungal β-amylase and amyloglucosidase on some Nigerian agricultural residues. Food Bioprocess Tech 2010;3(5):693-8. 17. Chethan S, Sreerama Y, Malleshi N. Mode of inhibition of finger millet malt