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Fenugreek seeds estrogenic activity in ovariectomized female rats

of estrogen on the rat uterus? Climacteric . 2012;16(1):161-8. 38. Jefferson WN, Couse JF, Padilla-Banks E, Korach KS, Newbold RR. Neonatal exposure to genistein induces estrogen receptor (ER) α expression and multioocyte follicles in the maturing mouse ovary: evidence for ERβ-mediated and nonestrogenic actions. Biol Reprod . 2002;67(4):1285-96. 39. Hewitt SC, Deroo BJ, Hansen K, Collins J, Grissom S, Afshari CA, et al. Estrogen Receptor-Dependent Genomic Responses in the Uterus Mirror the Biphasic Physiological Response to Estrogen. Mol Endocrinol

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Anticholinesterase and antioxidant activities of foliar extract from a tropical species: Psidium guajava L. (Myrtaceae) grown in Algeria

References 1. Yoshikawa T, Naito Y. What Is Oxidative Stress? J Am Vet Med Assoc . 2002;45(7):271-6. 2. Saxena M, Saxena J, Pradhan A. Flavonoids and phenolic acids as antioxidants in plants and human health. Int J Pharm Sci Rev Res . 2012;16(2):130-4. 3. Verdile G, Keane KN, Cruzat VF, Medic S, Sabale M, Rowles J. et al. Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease. Mediators Inflamm . 2015:1-17. 4. EtindelSosso FA, Nakamura O, Nakamura M. Epidemiology of

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A variety of processes that affect the perception of skin aging

, Hartle DK, Swanson RB, Hargrove JL. Inhibition of protein glycation by extracts of culinary herbs and spices. J Med Food . 2008;11(2):275-81. 71. Thirunavukkarasu V, Anitha Nandhini AT, Anuradha C V. Fructose diet-induced skin collagen abnormalities are prevented by lipoic acid. Exp Diabesity Res. 2004;5(4):237-44. 72. Tarwadi K V, Agte V V. Effect of micronutrients on methylglyoxal-mediated in vitro glycation of albumin. Biol Trace Elem Res. 2011; 143(2):717-25. 73. Darvin ME, Sterry W, Lademann J, Patzelt A. Alcohol consumption decreases the

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Disease perception and coping strategies for stress in Polish patients with various mental disorders

: mediators between disease severity and psychological well-being and quality of life among patients with Crohn’s disease. Patient Prefer Adherence. 2016; 10: 2387–2396. 22. Pużyński S. Choroba psychiczna-problem z definicją oraz miejscem w diagnostyce regulacjach prawnych. Psychiatria Polska. 2007; 41 (3), 299-308. 23. Pyrcak M. Orzekanie oraz wykonywanie detencji psychiatrycznej (art. 94 k.k.) w praktyce sądów rejonowych. Sprawozdanie z przeprowadzonych badań. Czasopismo Prawa Karnego i Nauk Penalnych. 2011; XV, 1, 99-136. 24. Juczyński Z. Ogińska

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Gene therapy for haemophilia: a very modern success story

References 1. Morris J. Patient advocacy helps patients weigh up gene therapy trial risk/benefits. J Haem Pract 2015; 2(1): 6-8. doi: 10.17225/jhp.00040. Avaialble at 2. Nathwani AC, Tuddenham EG, Rangarajan S, et al. Adenovirus-associated virus vector-mediated gene transfer in hemophilia B. N Engl J Med 2011; 365(25): 2357-65. doi: 10.1056/NEJMoa1108046.

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Assessment of TGF-β and IL10 levels in human brucellosis

REFERENCES 1. Skendros P. et al.: Cell-mediated immunity in human brucellosis. Microbes Infect. 2011;13:134. 2. Gomez G. et al.: Host-Brucella interactions and the Brucella genome as tools for subunit antigen discovery and immunization against brucellosis. Front Cell Infect Microbiol.,3,1,2013. 3. Mangodt TC. et al.: The role of Th17 and Treg responses in the pathogenesis of RSV infection. Pediatr Res.,78,483,2015. 4. Mohammadnia-Afrouzi M. et al.: Altered microRNA Expression and Immunosuppressive Cytokine Production by Regulatory T Cells

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The influence of montelukast on the autonomic nervous system activity in rats with cyclophosphamide-induced hemorrhagic cystitis

References 1. Altayli E. et al.: Prevention and treatment of cyclophosphamide and ifosfamide-induced hemorrhagic cystitis. J. Mol. Pathophysiol., 1, 53, 2012. 2. Benarroch E.E.: Autonomic-mediated immunomodulation and potential clinical relevance. Neurology, 73, 236, 2009. 3. Bouchelouche K. et al.: Increased urinary leukotriene E4 and eosinophil protein X excretion in patients with interstitial cystitis. J. Urol., 166, 2121, 2001. 4. Bouchelouche K. et al.: The action of cysteinyl

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Abnormal Levels of Inflammatory and Oxidative Stress Markers in Patients with Arterial Hypertension and Diabetes Mellitus


Individuals with hypertension and diabetes mellitus are at high risk of cerebrovascular and cardiovascular morbidity and mortality. Recent advances in the multifactorial pathophysiology of atherogenesis provide important information about the complex interrelations between traditional risk factors, inflammation and oxidative stress in mediating all stages of atherosclerosis. The objective of the study was to determine if some inflammatory and oxidative stress markers in patients with arterial hypertension and diabetes mellitus differ from those in healthy age-matched controls. Our results revealed a significant difference in blood pro/antioxidant activities in hypertensive diabetics and the controls. The investigation of inflammatory and oxidative stress markers along with traditional risk factors proves useful in complex assessment of vascular risk and primary prophylaxis of cerebrovascular and cardiovascular events.

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Electro-acupuncture on Nei Guan and Bai Hui: How Does It Affect GRP78 and Caspase-12 Gene Expression in Rats with Ischemia-Reperfusion Injury

References 1 Uznetsov G,Chen L B,Nigam S K . Multiple molecular chaperones complex with misfolded large oligomeric glycoproteins in the endoplasmic reticulum. Biol Chem,1997,272(5):3057-3063. 2 Li-Ying GUAN, Cai-Min XU, Hua-Zhen PAN. Endoplasmic reticulum stress-mediated apoptosis. Progress in Biochemistry and Biophysics,2007,34(11):1136-1141. 3 Shibata M,Hattofi H,Sasaki T, et al.Activation of caspase-1 2 by endoplasmic reticulum stress induced by transient middle cerebral artery occlusion in mice

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The influence of 1.4-naphtoquinone derivative and of vitamin E on nitroso-oxidative processes in digestive organ mucous membranes under the conditions of cyclooxygenase blockage, and against the background of low intensity X-ray irradiation


In recent years, the influence of chronic low intensity irradiation on the human body has increased. This is mediated not only by the consequences of technogenic catastrophies, but also due to application of radiation therapy of of radiation usage in industry. Hence, we investigated the influence of 1.4-naphtoquinone and vitamin Е on the nitroso-oxidative processes in the digestive organ mucous membranes, while affected by low intensity X-ray irradiation alone and in combination with the experimental blockage of COX, in rats. Our results show that X-ray irradiation of a total dose of 20 sGy during twenty days, induced an increase of the oxidative processes, as well as an increase in the activity of iNOS and myeloperoxidase in the mucous membranes of the stomach, small and large intestine. Both the effect of vitamin E and a 1.4-naphtoquinone derivative on the background of low intensity X-ray irradiation, and under the simultaneous effect of X-ray irradiation and COX blockage, brought about a decrease of the level of oxidative processes and of iNOS activity, whereas MPO activity increased. We also noted that the effect of vitamin E on the background of X-ray irradiation more significantly increased both the activity of SOD and catalase, when compared to the induced effect of the 1.4-naphtoquinone derivative. Under the conditions of COX-1/COX-2 blockage (as induced by way of indomethacin administration), against the background of X-ray irradiation, the content of TBA-active products (in the stomach and small intestine mucous membranes), the level of iNOS activity and the sum of nitrites and nitrates, were lower than that of independent effect. Тaking into account the prominent antioxidant and anti-inflammatory attributes of 1.4-naphtoquinone-3-[3-(3.5-di-tret-butyl-4-hydroxy-phenyl)-1.4-dihydronaphtalene-2-aminoil] butyrate, when compared to the effect of sole administration of vitamin E, both under the conditions of X-ray irradiation alone, and the simultaneous effect of X-ray irradiation and COX blockage, this derivative may be considered suitable as a perspective radiprotectant.

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