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Prognostic value of soluble angiotensin II receptor 1 and soluble angiotensin converting enzyme (CD 143) in patients with acute leukemia

Introduction There is increasing evidence that angiotensin II (Ang II), a major regulator of blood pressure and cardiovascular homeostasis, is involved in the regulation of cell proliferation, angiogenesis, inflammation and tissue remodeling, which suggests that this peptide might also play a role in cancer [ 1 ]. The renin-angiotensin system (RAS) has been characterized extensively in hypertension and atherosclerosis, but recently its relevance to the fields of oncology and hematology are being studied [ 2 , 3 ]. The RAS pathway mediates its effect

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Selected factors influencing angiogenesis and hematopoietic niche

Hematopoiesis is a complex process, which takes place in the bone marrow microenvironment in a so-called hematopoietic niche. Within the hematopoietic niche, osteoblastic, and vascular parts are distinguished. The osteoblastic part of the HSC niche is responsible for maintenance of dormant, resting HSC, while active, dividing HSCs are located mainly near endothelial cells (EC) in the vascular part of the niche [ 1 ]. The close relation of the hematopoietic cells with stromal cells is mediated by interactions of adhesive molecules with respective ligands

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Use of MPV and MPV/Plt Ratio in the Differentiation of Migraine and Tension-Type Headache

diagnosis of migraine and TTHs before. Many years ago, it was hypothesized that migraine is a primary Plt dysfunction [ 21 ]. It was determined that levels of Plt-activating factor, which has an important role in many inflammatory and thrombotic processes and is the mediator in phospholipid structure, increase during attacks [ 19 ]. In a study performed by Hanington et al., it was determined that spontaneous Plt aggregation and Plt adhesion are higher in the Plts of migraine patients in the headache-free period compared to the same in the healthy control group, and

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Constriction of Fetal Ductus Arteriosus and Maternal Intake of Polyphenol-Rich Foods

normal and persistent ductus arteriosus of the dog. Am J Pathol 1989, 135 (5): 881-7 7. Majed BH, .: Molecular mechanisms regulating the vascular prostacyclin pathways and their adaptation during pregnancy and in the newborn. Pharmacological Reviews, 2012 8. Slomp J., et al.: Differentiation, dedifferentiation, and apoptosis of smooth muscle cells during the development of the human ductus arteriosus. Arterioscler Thromb Vasc Biol, 1997. 17(5): 1003-9 9. Hong Z., et al.: Role of dynamin-related protein 1 (Drp1)-mediated

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Znaczenie adrenaliny w mechanizmie aktywacji ludzkich płytek krwi

Blood 2012 120 e73 e82 [19] Woulfe DS. Platelet G protein-coupled receptors in hemostasis and thrombosis. J Thromb Haemost 2005;3:2193–200. 10.1111/j.1538-7836.2005.01338.x 16194198 Woulfe DS Platelet G protein-coupled receptors in hemostasis and thrombosis J Thromb Haemost 2005 3 2193 200 [20] Wettschureck N, Moers A, Offermanns S. Mouse models to study G-protein-mediated signaling. Pharmacol Ther 2004;101:75–89. 10.1016/j.pharmthera.2003.10.005 14729394 Wettschureck N Moers A Offermanns S Mouse models to study G-protein-mediated

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Review Paper. Transplacental Digoxin Treatment In Prenatal Cardiac Problems In Singleton Pregnancies - Meta Analysis (Based On Literature: 1992–2015)

1996,1,31-36 36. ShartonML, Irani WN, Hall SA, Marcoux LG, Page RL, Grayburn PA, Eichhorn EJ. Does digoxin provide additional hemodynamic and autonomic benefit at higher doses in patients with mild to moderate heart failure and normal sinus rhythm? J Am Coll Cardiol 1997, 29,1206-1213 37. Cuneo BF, Lee M, Roberson D, Niksch A, Ovadia M, Parilla BV, Benson DW.: A management strategy for fetal immune-mediated atrioventricular block. J Matern Fetal Neonatal Med. 2010, 23 (12), 1400-1405 38. Wiggins JW Jr, Bowes W, Clewell

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Retrospection of the effect of hydroxyurea treatment in patients with sickle cell disease

induction HU has been in use for the treatment of SCD over many years. The main rationale behind the usage of HU for the treatment of SCD is its ability to induce HbF [ 19 ]. The possible cellular and vascular effects of HU are depicted in Figure 3 . Several lines of evidence suggest that HU elicits HbF induction and offers clinical benefits to SCD patients through a wide range of possible mechanisms [ 20 ]. The precise mechanism of HbF induction by HU is not fully known; however, it is mediated mainly by the redox inactivation of a tyrosyl radical on the enzyme

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Wenetoklaks w leczeniu chorób układu krwiotwórczego i guzów litych

826 33 [65] Agarwal R, Chan YC, Tam CS, et al. Dynamic molecular monitoring reveals that SWI-SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma. Nat Med 2019;25:119-29. 30455436 10.1038/s41591-018-0243-z Agarwal R Chan YC Tam CS et al Dynamic molecular monitoring reveals that SWI-SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma Nat Med 2019 25 119 29 [66] Tam CS, Anderson MA, Pott C, et al. Ibrutinib plus Venetoclax for the Treatment of Mantle-Cell Lymphoma. N Engl J

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Nivolumab for relapsed/refractory classical Hodgkin lymphoma after brentuximab vedotin failure – Polish Lymphoma Research Group real-life experience

. Histopathologically cHL is characterized by minority of malignant cells represented by clonal malignant Hodgkin and Reed-Sternberg (HRS) cells and the domination of inflammatory and immune cells [ 3 , 4 ]. The HRS cells present the expression of CD30 antigen and produce molecules inhibiting T-cell-mediated immune response [ 5 ]. HRS cells achieve immune evasion by multiple mechanisms including enhanced expression of programmed cell death-1 ligands (PD-L1 and PD-L2) that bind programmed cell death protein 1 (PD-1) on the surface of antigen-experienced T cells to suppress T

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Immunoterapia z użyciem przeciwciał monoklonalnych ukierunkowanych na szlak PD-1/PD-L1 w chorobach nowotworowych
Monoclonal antibodies against PD-1/PD-L1 pathway

.10.6738 Kinter AL Godbout EJ McNally JP Sereti I Roby GA O’Shea MA et al The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands J Immunol 2008 181 10 6738 – 46 [21] Polanczyk MJ, Hopke C, Vandenbark AA, Offner H. Estrogen-mediated immunomodulation involves reduced activation of effector T cells, potentiation of Treg cells, and enhanced expression of the PD-1 costimulatory pathway. J Neurosci Res. 2006;84(2):370– 8. Polanczyk MJ Hopke C Vandenbark AA Offner H

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