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Disease perception and coping strategies for stress in Polish patients with various mental disorders

: mediators between disease severity and psychological well-being and quality of life among patients with Crohn’s disease. Patient Prefer Adherence. 2016; 10: 2387–2396. 22. Pużyński S. Choroba psychiczna-problem z definicją oraz miejscem w diagnostyce regulacjach prawnych. Psychiatria Polska. 2007; 41 (3), 299-308. 23. Pyrcak M. Orzekanie oraz wykonywanie detencji psychiatrycznej (art. 94 k.k.) w praktyce sądów rejonowych. Sprawozdanie z przeprowadzonych badań. Czasopismo Prawa Karnego i Nauk Penalnych. 2011; XV, 1, 99-136. 24. Juczyński Z. Ogińska

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Self-image and selected clinical variables in the context of childhood abuse in subjects with alcohol dependence

and aggression: mediator effect of childhood trauma. Compr Psychiatry.2012;53(3):252-258.

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Gene therapy for haemophilia: a very modern success story

References 1. Morris J. Patient advocacy helps patients weigh up gene therapy trial risk/benefits. J Haem Pract 2015; 2(1): 6-8. doi: 10.17225/jhp.00040. Avaialble at 2. Nathwani AC, Tuddenham EG, Rangarajan S, et al. Adenovirus-associated virus vector-mediated gene transfer in hemophilia B. N Engl J Med 2011; 365(25): 2357-65. doi: 10.1056/NEJMoa1108046.

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International databases open the door to improved care for rare bleeding disorders

-55. 4. Peyvandi F, Palla R, Menegatti M, et al. Coagulation factor activity and clinical bleeding severity in rare bleeding disorders: results from the European Network of Rare Bleeding Disorders. J Thromb Haemost 2012; 10(4): 615-21. doi: 10.1111/j.1538-7836.2012.04653.x. 5. Nathwani AC, Tuddenham EG, Rangarajan S, et al. Adenovirus-associated virus vector-mediated gene transfer in hemophilia B. N Engl J Med 2011;365(25): 2357-65. doi: 10.1056/NEJMoa1108046. 6. Ward NJ, Buckley SM, Waddington SN, et al. Codon optimization of human

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Gene therapy for haemophilia: an update on progress in clinical trials

. White GC, Monahan PE. Gene therapy for haemophilia A. In: Lee CA, Berntorp EE, Hoots K, editors. Textbook of Haemophilia. 2nd ed. Hoboken, NJ: Wiley- Blackwell; 2005. 14. Manno CS, Chew AJ, Hutchison S, et al. AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe haemophilia B. Blood 2003; 101(8): 2963- 2972 15. Manno CS, Pierce GF, Arruda VR, et al. Successful transduction of liver in haemophilia by AAV-Factor IX and limitations imposed by the host immune response. Nat Med 2006; 12(3): 342

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Caregiver burden in haemophilia: results from a single UK centre

with a long-term condition: a rapid structured review of the literature. Health Expect 2015; 18(4): 452-74. 22. Murphy NA, Christian B, Caplin DA, Young P. The health of caregivers for children with disabilities: caregiver perspectives. Child Care Health Dev. 2007; 33(2): 180-7. 23. Mullins LL, Wolfe-Christiansen C, Chaney JM, et al. The relationship between single-parent status and parenting capacities in mothers of youth with chronic health conditions: the mediating role of income. J Pediatr Psychol 2011; 36(3): 249

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Mechanisms promoting and inhibiting the process of proteasomal degradation of cells


Defects in the process of degradation of unneeded cellular proteins underlie many diseases. This article discusses one of the most important systems of removal of abnormal proteins. It describes the process of ubiquitination of proteins for proteasome degradation. It also describes the structure of the 26S and 20S proteasomes and the mechanism of ubiquitin-proteasome system. Proteasome proteolytic system is highly specialized and organized. Protease-proteasome 26S is particularly important for proper cell functioning. It recognizes and degrades marked proteins. Inhibition of proteasome pathway leads to cell cycle arrest and apoptosis.

Efficient degradation of cellular proteins by UPS (the ubiquitin - proteasome system) - is important for signal transduction, transcriptional regulation, response to stress and the activity control of cell receptors.

The development of many diseases has its origin in the dysfunction of the UPS route. This group includes diseases such as cancer, neurodegenerative disorders, immune-mediated diseases and infectious diseases. Development of effective methods for pharmacological intervention in the functioning of this system has become a great challenge. The use of specific, low molecular-weight proteasome inhibitors and enzymes catalyzing the ubiquitination gives hope for new, targeted therapies.

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“Pulling hair out of the head” - the importance of traumatic family events in the development and maintenance of trichotillomania symptoms - case report


Introduction: Trichotillomania is a mental disorder characterized by a repetitive and compulsive hair pulling, classified in ICD-10 to a group of habit and impulse disorders, and in the DSM-5 to the group of obsessive-compulsive disorders.

Aim: The aim of the study is to present on the basis of case study:1). the importance of traumatic family experiences in releasing as well as maintaining the symptoms of Trichotillomania, 2). comprehensive medical care, the application of which has resulted in a beneficial therapeutic effect.

Results: In the described case of 16-year-old patient, Trichotillomania was triggered by traumatic events related to lack of support and family stabilization resulting from parental disputes and grandfather’s death, when she was 11 years old. The subsequent years of her life, in spite of the divorce of her parents and their separate residence, abounded in periods of turbulent quarrels between the parents in which she was involved. Each time this type of incident was associated with the recurrence of behavior associated with Trichotil-lomania, the course of which was more severe with the occurrence of self-harm and suicidal thoughts.

Conclusions: 1. In the described case, traumatic events and pathological relations of the immediate family members were not only thetriggering factor, but also maintaining the Trichotillomania symptoms. 2. In accordance with the guidelines of Trichotillomania Learning Center-Scientific Advisory Board (2008), the use of a comprehensive treatment including both the patient - individual psycho-therapy (especially cognitive-behavioral therapy) and pharmacotherapy, as well as her family (family psychotherapy, family mediation, workshops for parents), brought about positive therapeutic effects.

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EASE: Examination of Anomalous Self-Experience

. 2012; 200: 632-636. 20. Nelson B, Thompson A, Yung AR. Not all first-episode psychosis is the same: preliminary evidence of greater basic self-disturbance in schizo-phrenia spectrum cases. Early Interv Psychiatry. 2013; 7(2): 200-204. 21. Škodlar B, Parnas J. Self-disorder and subjective dimensions of suicidality in schizophrenia. Compr Psychiatry. 2010; 51: 363-366. 22. Haug E, Melle I, Andreassen OA, Raballo A, Bratlien U, Øie M, et al. The association between anomalous self-experience and suicidality in first-episode schizophrenia seems mediated

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Safety of concomitant treatment with Non-Vitamin K Oral Anticoagulants and SSRI/SNRI antidepressants

, Siniscalchi A, et al. Pharmacokinetic drug-drug interaction and their implication in clinical management. J Res Med Sci. 2013; 18(7):601-10. 22. Kennedy C, Brewer L, Williams D. Drug interactions. Medicine. 2016; 44(7): 422–426. 23. Zanger UM, Raimundo S, Eichelbaum M. Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry. Naunyn Schmiedebergs Arch Pharmacol. 2004; 369(1):23-37. 24. Scheen AJ. Cytochrome P450-mediated cardiovascular drug interactions. Expert Opin Drug Metab Toxicol. 2011; 7(9):1065-82. 25. Mulder H

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