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Nitric oxide – mediated signalization and nitrosative stress in neuropathology / Azot oksid – posredovana signalizacija i nitrozativni stres u neuropatologiji

protein aggregation. Science 2001; 292: 1552-5. 31. Barsoum MJ, Yuan H, Gerencser AA, Liot G, Kushnareva Y, Graber S et al. Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. EMBO J 2006; 25: 3900-11. 32. Cho DH, Nakamura T, Fang J, Cieplak P, Godzik A, Gu Z et al. S-Nitrosylation of Drp1 mediates beta-amyloidrelated mitochondrial fission and neuronal injury. Science 2009; 324: 102-5. 33. Bolaños JP, Heales SJR, Land JM, Clark JB. Effect of peroxynitrite on the mitochondrial

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Clinical Significance of Increased Serum Neopterin in Chronic Kidney Failure as a Biomarker of Cell-Mediated Immunity

H. Serum neopterin levels in children with primary nephrotic syndrome. Acta Paediatr 2006; 95(7): 854–6. 8. Formanowicz D. Neopterin in patients with chronic kidney disease and patients with coronary artery disease. Biotechnologia 2012; 93(1): 59–67. 9. Yadav AK, Sharma V, Jha V. Association between serum neopterin and inflammatory activation in chronic kidney disease. Mediators Inflamm 2012; 476979: 2012. 10. Ristovski-Kornic D, Stefanović A, Kotur-Stevuljević J, Zeljković A, Spasojević-Kalimanovska V, Vekić J, Miljković M, Paripović D, Peco

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TNF-α Mediated Secretory Component is Positively Regulated by PI3K/AKT/MTOR in CACO-2 Cells

D-Y, Wang Xue-Lian, Liu Pei. TNF-alpfa upregulates the expression of immunoglobulin secretory component. J Investig Allergol Clin Immunol 2007; 17: 101-6. 11. Takenouchi-Ohkubo N, Moro I, Mukae S, et al. Tumour ne crosis factor-alpha-mediated human polymeric immu - no globulin receptor expression is regulated by both mitogen- activated protein kinase and phosphatidylinositol-3-kinase in HT-29 cell line. Immunology 2008; 123: 500-7. 12. Takenouchi-Ohkubo N, Asano M, Chihaya H, Chungh - suing WU, Ishikasa K, Moro I. Retinoic acid

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Detection of lipoprotein X (LPX) – a challenge in patients with severe hypercholesterolaemia

. Rapid normalization of severe hypercholesterolemia mediated by lipoprotein X after liver transplantation in a patient with cholestasis – a case report. Acta Biochim Pol 2015; 62: 621–3. 10.18388/abp.2015_971 Jankowski K Wyzgal A Wierzbicka A Tronina O Durlik M Pruszczyk P Rapid normalization of severe hypercholesterolemia mediated by lipoprotein X after liver transplantation in a patient with cholestasis – a case report Acta Biochim Pol 2015 62 621 3 3 Phatlhane DV, Zemlin AE. Severe hypercholesterolemia mediated by lipoprotein X

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Oral cavity-derived exosomes as promising tool in chronic wound healing

immunological and profibrogenic mediators, comparing to skin. On the other hand, mucosa can be characterized by highly effective epithelial renewal and fast-rate proliferation of underlying fibroblasts [ 30 ]. All this can be attributed to the presence of cells with stemness features, enabling continuous restoration of tissues from the oral cavity [ 31 ]. Furthermore, salivary exosomes have been identified as highly informative nanovesicles. They have shown a pathway and machinery by which cancer-derived biomarkers can be ferried through the systemic circulation into the oral

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Analysis of expression of genes responsible for regulation of cellular proliferation and migration – microarray approach based on porcine oocyte model

that VEGFA interacts with other genes including INSR and KIT, which also belong to both ontology groups ( Fig. 6 ). which is confirmed by the research of our team [ 22 , 23 ]. Another interesting gene is the insulin receptor INSR. Insulin plays an important role in the ovary because it is an important mediator for the development of follicles, steroidogenesis, oocyte maturation as well as embryo development. INSR was first identified in the granular cells of antral human follicles and is the insulin receptor mediating the action of insulin on oocytes. In 2008, INSR

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Differential expression pattern of genes involved in oxygen metabolism in epithelial oviductal cells during primary in vitro culture

fertilization, as well as in gamete and embryo transport through an influence on prostaglandin production [ 15 ]. IL24 encodes interleukin 24, a cytokine expressed in the tissues of immune system, such as the thymus, spleen, peripheral blood leukocytes and melanocytes, involved in immune regulation, wound healing and protection against bacterial infections. However, at supra-physiological levels, it exerts anti-cancer properties, such as apoptosis induction, inhibition of invasion or autophagy [ 16 ]. Moreover, IL-24-mediated apoptosis is limited to cancer cells without

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Ovarian follicular cells - living in the shadow of stemness cellular competence

Introduction Granulosa cells (GCs), otherwise known as ovarian follicular cells, are the largest component of follicular fluid [ 1 ]. Alongside GCs are theca cells, ovarian surface epithelial (OSE) cells, and oocytes. Together, the Graafian follicle will form to protect the oocyte (folliculogenesis) and germ cells also mature into an egg (oogenesis) [ 2 , 3 ]. Granulosa cells have small cell-secreted vesicles called exosomes which are essential in mediating communication between cells, and they share this role with gap junctions [ 4 ]. Exosomes secrete small

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Rosiglitazone-induced changes in the oxidative stress metabolism and fatty acid composition in relation with trace element status in the primary adipocytes

of Timolol Treatment on Pancreatic Antioxidant Enzymes in Streptozotocin-induced Diabetic Rats: An Experimental and Computational Study J Med Biochem 2019 38 306 316 10.2478/jomb-2018-0034.eCollection2019Jul 19 Uchida K. 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress. Prog Lipid Res 2003; 42: 318–43. 10.1016/S0163-7827(03)00014-6 12689622 Uchida K 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress Prog Lipid Res 2003 42 318 43 20 Cusi K. The role of adipose tissue and lipotoxicity in the pathogenesis of

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The genes regulating maintenance of cellular protein location are differentially expressed in porcine epithelial oviductal cells during longterm in vitro cultivation

Involvement of a P2X7 Receptor in the Acrosome Reaction Induced by ATP in Rat Spermatozoa J Cell Physiol 2015 230 3068 75 10.1002/jcp.25044 29 Lawn RM, Wade DP, Garvin MR, Wang X, Schwartz K, Porter JG, Seilhamer JJ, Vaughan AM, Oram JF. The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway. J Clin Invest. 1999;104:R25-31; DOI:10.1172/JCI8119. 10.1172/JCI8119 10525055 Lawn RM Wade DP Garvin MR Wang X Schwartz K Porter JG Seilhamer JJ Vaughan AM Oram JF The Tangier disease

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