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AM Alaqeel, H Abou Al-Shaar, RK Shariff and A Albakr

2 (DM2) Expansion in non coding region TDP-43: trans-activation response (TAR) element DNA-binding protein 43; miR: microRNA; HAR1: human accelerated region 1; DGCR5: DiGeorge syndrome critical region gene 5; FUS/TLS: fused in sarcoma/translocated in sarcoma; TUG1: taurine up-regulated 1; NEAT1: nuclear enriched abundant transcript 1; RAN: repeat-associated non-ATG; UPF3B: UPF3 regulator of nonsense transcripts homolog B; SMN2: survival of motor neuron 2. One of the common molecular events is oxidative stress, which affects protein folding