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Georgios Lypas

patients treated with breast-conserving therapy (BCT) for breast cancer arising in patients with BRCA1/2 mutations, compared with sporadic cases. However, these patients run quite higher risk of a new primary, either at the ipsilateral or the contralateral breast (10–20% vs 1–3%) ten years after the initial diagnosis. The lifetime risk of a new primary seems to be higher for women who are diagnosed young with their first breast cancer. Among triple negative breast cancer tumours, BRCA1/2 mutation is a predictor of sensitivity in platinum-based agents, in comparison

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Matej Rebersek, Masa Kanduser and Damijan Miklavcic

-84. Wang J, Zhan Y, Ugaz VM, Lu C. Vortex-assisted DNA delivery. Lab Chip 2010; 10: 2057-61. Rebersek M, Corovic S, Sersa G, Miklavcic D. Electrode commutation sequence for honeycomb arrangement of electrodes in electrochemotherapy and corresponding electric field distribution. Bioelectrochemistry 2008; 74: 26-31. Faurie C, Rebersek M, Golzio M, Kanduser M, Escoffre JM, Pavlin M, et al. Electro-mediated gene transfer and expression are controlled by the life-time of DNA/membrane complex formation. J Gene Med

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Domen Plut, Barbara Faganel Kotnik, Irena Preloznik Zupan, Damjana Kljucevsek, Gaj Vidmar, Ziga Snoj, Carlo Martinoli and Vladka Salapura

28 28 28 No. of lifetime joint bleeds : 5 5 12 15 14 13 0–5 (joint count) 12 11 7 10 4 2 6–20 (joint count) > 20 (joint count) 13 12 5 3 9 12 Unknown (joint count) 0 1 1 0 1 1 HJHS 2.1 score: mean; max* 3.3; 12 2.6; 11 1.4; 7 1.2; 8 1.9; 9 1.9; 8 * Minimum was 0 for all the scores In our series, the disease presentation was quite variable with a mean HJHS 2.1 score of 2.3 (range 0–12). HJHS scores were the highest in the ankle and the lowest in the knee

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Tadej Dovšak, Alojz Ihan, Vojislav Didanovič, Andrej Kansky and Nataša Hren

cardiothoracic surgery. Clin Exp Immunol 1999; 115: 315-23. Fjaertoft G, Håkansson LD, Pauksens K, Sisask G, Venge P. Neutrophil CD64 (FcgammaRI) expression is a specific marker of bacterial infection: a study on the kinetics and the impact of major surgery. Scand J Infect Dis 2007; 39: 525-35. Nieto A, Sánchez MJ, Martínez C, Castellsagué X, Quintana MJ, Bosch X, et al. Lifetime body mass index and risk of oral cavity and oropharyngeal cancer by smoking and drinking habits. Br J Cancer 2003; 89: 1667

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Justin Teissié, Jean Escoffre, Marie Rols and Muriel Golzio

-induced mammalian-cell-membrane permeabilization, gene transfer and resulting expression. Eur J Biochem 1998; 254 : 382-8. Pucihar G, Mir LM, Miklavcic D. The effect of pulse repetition frequency on the uptake into electropermeabilized cells in vitro with possible applications in electrochemotherapy. Bioelectrochemistry 2002; 57 : 167-72. Teissie J, Rols MP. Manipulation of cell cytoskeleton affects the lifetime of cell membrane electropermeabilization. Ann N Y Acad Sci 1994; 720 : 98

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Vesna Zadnik, Maja Primic Zakelj, Katarina Lokar, Katja Jarm, Urska Ivanus and Tina Zagar

incidence figures, neither are any new cancers of the same histology appearing in the same organ, e.g . multiple lesions of the colon. Prevalence is the number of all cancer patients that are alive on a given date, regardless of when they were diagnosed with cancer. Lifetime cancer prevalence is defined as all persons living and had ever been diagnosed with cancer, while partial prevalence counts only those patients, diagnosed with cancer within a defined period of time e.g . 1, 5 or 10 years before the date on which prevalence is calculated. Incidence and prevalence

Open access

Stefan Janssen, Heinke C Hansen, Liesa Dziggel, Steven E Schild and Dirk Rades

= 0.064). Since the risk of developing neuro-cognitive deficits increases with lifetime, longer-term surviving patients should not be treated with doses per fraction of 3 Gy or higher. 6 The risk of neurocognitive decline may also be reduced with sparing of the hippocampal neural stem-cell compartment and administration of memantine. 7 , 8 , In contrast to longer-term survivors, patients with a very short remaining lifespan should receive WBRT with a short overall treatment time to avoid that they spend more time than necessary on a radiation oncology ward or

Open access

Jasna Cotic, Jure Jamsek, Milan Kuhar, Natasa Ihan Hren, Andrej Kansky, Mutlu Özcan and Peter Jevnikar

activities with greater confidence. However, comprehensive prosthetic treatment after head and neck cancer is challenging, time-consuming and costly. Therefore, only 40% of such patients are treated following the postsurgical prosthetic protocol. Among them, 70% receive dentures supported by the residual teeth and bone and 30% receive implant-supported dentures. 7 Edentulous patients with head and neck cancer after radiation therapy are an especially vulnerable subgroup. Radiation treatment sequelae persist throughout the patient's lifetime and in the past, radiation

Open access

Vaneja Velenik, Ajra Secerov-Ermenc, Jasna But-Hadzic and Vesna Zadnik

Introduction Cancer burden in Slovenia is increasing. There are approximately 14,000 new cancer patients annually (age standardized incidence rate (world) = 335/100,000), the life-time prevalence is almost 100,000. More than 10,000 patients are currently in the process of primary cancer treatment; almost 30,000 have recently completed a specific oncological treatment but have still been followed by oncologists. 1 Because of improvements in diagnostics and treatment we are observing a constant increase in cancer patients’ survival. Five-year relative

Open access

Bojan Tepes, Maja Seruga, Miroslav Vujasinovic, Dejan Urlep, Liljana Ljepovic, Jurecic Nataša Brglez, Alenka Forte, Ljubec Anita Kek and Miha Skvarc

more than pepsinogen II, which is produced also in antrum. Gastropanel (Biohot Ojy, Finland) has set cut-off for corpus atrophy at PGI/PGII < 3 and/or PGI < 30 μg/L). If a patient is not on PPI therapy, increased Gastrin 17 can be another marker of low gastric acid secretion and corpus atrophy. Gastrin 17 is lower than normal in case of atrophy in antrum, or in case of gastric hypersecretion. 9 H. pylori seropositivity is a risk factor for gastric cancer and up to 2.9% of infected patients can develop gastric cancer in their lifetime. 10 Serologic biopsy is more