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Vanja Filipovski, Katerina Kubelka-Sabit, Dzengis Jasar, Gligor Dimitrov and Vesna Janevska

complexity emerges from the ashes of genetic reductionism. J Mol Recognit 2004; 17: 145-148. 12. Fukino K, Shen L, Matsumoto S, et al . Combined total genome loss of heterozygosity scan of breast cancer stroma and epithelium reveals multiplicity of stromal targets. Cancer Res 2004; 64: 7231-7236. 13. Olumi AF, Grossfeld GD, Hayward SW, et al . Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res 1999; 59: 5002-5011. 14. Barcellos-Hoff MH, Ravani SA. Irradiated mammary gland stroma promotes

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Vаnja Dzambazovska-Trajkovska, Jordan Nojkov, Adrijan Kartalov, Biljana Kuzmanovska, Tatjana Spiroska, Gjorgji Trajkovski, Nadica Geshkovska-Matevska and Aleksandar Dimovski

variable response to drugs: focus on opioids. Expert Opin Drug Metab Toxicol 2008; 4: 77-91. 48. Argoff CE. Clinical implications of opioid pharmacogenetics. Clin J Pain 2010; 26(10): S16-S20. 49. Jannetto PJ, Bratanow NC. Pharmacogenomic considerations in the opioid management of pain. Genome Medicine 2010; 15; 2(9): 66.

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Sorin Rugină

Dimensions. Clin Microbiol Rev. 2012;25:682-707. 4. Forslund K, Sunagawa S, Kultima JR, et al. Country-specific antibiotic use practices impact the human gut resistome. Genome Res. 2013;23:1163-69. 5. Pallecchi L, Bartoloni A, Riccobono E, et al. Quinolone Resistance in Absence of Selective Pressure: The Experience of a Very Remote Community in the Amazon Forest. PLoS Negl Trop Dis. 2012:6: 1790. doi: 10.1371/journal.pntd.0001790 6. Rugina S, Dumitru IM. The Role of infectious diseases specialist in critical patient

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Manuela Arbune, Silvia Fotea, Aurel Nechita and Victorita Stefanescu

meningoseptica comb. nov. and Elizabethkingia miricola comb. nov. Int J Syst Evol Microbiol. 2005;55(Pt 3):1287–93. 4. Breurec S, Criscuolo A, Diancourt L, et al. Genomic epidemiology and global diversity of the emerging bacterial pathogen Elizabethkingia anophelis . Sci Rep. 2016, 6:30379. 5. Chen S, Soehnlen M, Downes FP, Walker ED. Insights from the draft genome into the pathogenicity of a clinical isolate of Elizabethkingia meningoseptica Em3. Stand Genom Sci. 2017;12:56. 6. Jean SS, Lee WS, Chen FL, Ou TY, Hsueh PR. Elizabethkingia meningoseptica

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Raluca Dumache, Alexandru Florin Rogobete, Dorel Sandesc, Ovidiu Horea Bedreag, Veronica Ciocan, Camelia Muresan, Adrian Tudor Stan, Mihai Sandesc, Anca Dinu, Sonia Elena Popovici and Alexandra Enache

patients with primary and metastatic breast cancer. Breast Cancer Res . 2010;12:R90. 29. Guo Z, Maki M, Ding R, Yang Y, Zhang B, Xiong L. Genome-wide survey of tissue-specific microRNA and transcription factor regulatory networks in 12 tissues. Sci Rep . 2014;4. 30. Sood P, Krek A, Zavolan M, Macino G, Rajewsky N. Cell-type-specific signatures of microRNAs on target mRNA expression. Proc Natl Acad Sci USA . 2006;103:2746-2751. 31. Bloomston M, WL F, Petrocca F, et al. MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal