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Tashfeen Akhtar, Shahid Hameed, Najim Al-Masoudi, Roberta Loddo and Paolo Colla

In vitro antitumor and antiviral activities of new benzothiazole and 1,3,4-oxadiazole-2-thione derivatives

A series of new benzothiazole derivatives 6a-h have been synthesized, in five steps, from substituted phenols via the 1,3,4-oxadiazole-2-thiones 5a-h. The in vitro antitumor activity of the compounds obtained was investigated and the benzothiazol derivatives 6d and 6e showed strong effects on leukaemia cell lines CCRF-CEM (CC50 = 12 ± 2 μmol L-1, 8 ± 1 μmol L-1, respectively). These compounds are leading candidates for further development. The title compounds were tested against representatives of several virus families containing single stranded RNA genomes, either positive-sense (ssRNA+), or negativesense (RNA-), and against double-stranded RNA genomes (dsRNA), as well as some Flaviviridae viruses.

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Ali Razaghi, Roger Huerlimann, Leigh Owens and Kirsten Heimann

networks. Curr Opin Struct Biol. 2004;14:283-291. [4] Berger A, Cabal G, Fabre E et al. High-resolution statistical mapping reveals gene territories in live yeast. Nature Methods. 2008;5:1031-1037. [5] Boutanaev AM, Kalmykova AI, Shevelyov YY, Nurminsky DI. Large clusters of co-expressed genes in the Drosophila genome. Nature. 2002;420:666-669. [6] Bozinovic G, Sit TL, Di Giulio R, Wills LF, Oleksiak MF. Genomic and physiological responses to strong selective pressure during late organogenesis: few gene expression changes

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Guglielmo Giraldi, Angelo Fioravanti, Eugenia De Luca d’Alessandro, Maura Palmery and Lucia Martinoli

REFERENCES 1. D. D. Bikle, Vitamin D metabolism, mechanism of action, and clinical applications, Chem. Biol. 21 (2014) 319–329; DOI: 10.1016/j.chembiol.2013.12.016. 2. C. Carlberg, S. Seuter and S. Heikkinen, The first genome-wide view of vitamin D receptor locations and their mechanistic implications, Anticancer Res. 32 (2012) 271–282. 3. E. De Luca d’Alessandro, S. Bonacci and G. Giraldi, Aging populations: the health and quality of life of the elderly, Clin. Ter. 162 (2011) e13-e18. 4. A. Prentice, Vitamin D deficiency: a

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Septimiu Bucurescu

the short unique region in the genome of herpes simplex virus type 1, J. Mol. Biol.   181 (1985) 1-13; DOI: 10.1016/0022-2836(85)90320-1. H. M. Friedman, Immune evasion by herpes simplex virus type 1, strategies for virus survival, Trans. Am. Clin. Climatol Assoc.   114 (2008) 103-112. D. Westmoreland and J. F. Watkins, The IgG receptor induced by herpes simplex virus: studies using radioiodinated IgG, J. Gen. Virol.   24 (1974) 167-178; DOI: 10.1099/0022-1317-24-1-167. J. P. G

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Hussein N. Rubaiy

, SUR1, SUR2A, and SUR2B, J. Biol. Chem . 275 (2000) 28757–28763; DOI: 10.1074/jbc.M004818200. 20. M. Dean, A. Rzhetsky and R. Allikmets, The human ATP-binding cassette (ABC) transporter superfamily, Genome Res . 11 (2001) 1156–1166; DOI: 10.1101/gr.184901. 21. L. Aguilar-Bryan, J. P. Clement IV, G. Gonzalez, K. Kunjilwar, A. Babenko and J. Bryan, Toward understanding the assembly and structure of KATP channels, Physiol. Rev . 78 (1998) 227–245. 22. B. G. Gabrielsson, A. C. Karlsson, M. Lonn, L. E. Olofsson, J. M. Johansson, J. S. Torgerson

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Jagoda Abramek

References 1. Bhaijee F., Bell D.: Entamoeba gingivalis in Acute Osteomyelitis of the Mandible. Case Reports in Medicine, Article ID 357301, 2011. 2. Brown T.A. (2002). Genomes, 2nd edition. Department of Biomolecular Sciences, UMIST, Manchester, UK. Oxford: Wiley- Liss. Chapter in a book: 3,11. 3. Derda M. et al.: Incidence of Entamoeba gingivalis in the oral cavity of students. Journal of stomatology, 64, 10: 784-795, 2011. 4. Dominguez R., Holmes K.C.: Actin structure and function. Annual

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Adrian Jarzynski, Katarzyna Papiernik and Malgorzata Polz-Dacewicz

guardian of genome, Nature , 358: 15-16, 1992. 6. Lis P., Niczyj-Raucy M., Lis M.: The molecular basis of cancer and genetic methods of its diagnosis, Nat. J. (Opole) , 44: 92-119, 2011. 7. Nylander D.M, Dabelsteen E., Hall P.A.: The p53 molecule and its prognostic role in squamous cel carcinomas of the head and neck, J. Oral. Pathol. Med. , 29 (9): 413-425, 2000. 8. Rusin P., Markiewicz L., Majsterek I.: Genetic predeterminations of head and neck cancer, Post. Hig. Dos. , 62: 490-501, 2008. 9. Sznarkowska A., Olszewski R., Zawacka-Pankau J

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Katarzyna Kaszubska, Barbara Budzynska and Grazyna Biala

(EHIS)., 5, 2014. 5. Hannah N.: What is obesity? , 22.02.2015. 6. Hunt L.E. et al.: Complete re-sequencing of a 2Mb topological domain encompassing the FTO/IRXB genes identifies a novel obesity-associated region upstream of IRX5. Genome Med ., 10,1186/s13073-015-0250-3, 2015. 7. Jensen M.D. et al.: Guideline for the Management of Overweight and Obesity in Adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society. J. Am

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Renata Chalas, Magdalena Janczarek, Teresa Bachanek, Elzbieta Mazur, Maria Cieszko-Buk and Jolanta Szymanska

paracasei F19 has no longterm effect on caries experience. Caries Res., 47, 559, 2013. 7. Isselbacher K.J.: Irritable bowel syndrome: the possible benefits of probiotics. Postgrad. Med., 117, 7, 2005. 8. Kleerebezem M. et al.: Complete genome sequence of Lactobacillus plantarum WCFS1. Proc. Natl. Acad. Sci. U S A., 100, 1990, 2003. 9. Lee do K. et al.: Antimicrobial activity of Bifidobacterium spp. isolated from healthy adult Koreans against cariogenic microflora. Arch. Oral Biol., 56, 1047, 2011. 10. Lee SH

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Ewa Kedzierska, Lila Dabkowska, Tomasz Krzanowski, Ewa Gibula, Jolanta Orzelska-Gorka and Monika Wujec

zebrafish. Nat Rev Drug Discov. 2005;4:35-44. 33. Lieschke G, Currie PD. Animal models of human disease: zebrafish swim into view. Nat Rev Genet. 2007;8:353-67. 34. Howe K, Clark MD, Torroja CF, Torrance J, Berthelot C, Muffato M et al. The zebrafish reference genome sequence and its relationship to the human genome. Nature. 2013;496:498-503. 35. Pandey BU, Nichols CD. Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery. Pharmacol Rev. 2011;63:411-36. 36