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Open access

Fatemeh Khatami, Mahsa Mohammadamoli and Seyed Mohammad Tavangar

Abstract

Pheochromocytomas and paragangliomas (PPGLs) are tumors arising from the adrenal medulla and sympathetic/parasympathetic paraganglia, respectively. According to Th e Cancer Genome Atlas (TCGA), approximately 40% of PPGLs are due to germ line mutations in one of 16 susceptibility genes, and a further 30% are due to somatic alterations in at least seven main genes (VHL, EPAS1, CSDE1, MAX, HRAS, NF1, RET, and possibly KIF1B). Th e diagnosis of malignant PPGL was straight forward in most cases as it was defined as presence of PPGL in non-chromaffin tissues. Accordingly, there is an extreme need for new diagnostic marker(s) to identify tumors with malignant prospective. Th e aim of this study was to review all suggested genetic and epigenetic alterations that are remarkably different between benign and malignant PPGLs. It seems that more than two genetic mutation clusters in PPGLs and other genetic and methylation biomarkers could be targeted for malignancy discrimination in different studies.

Open access

Daniel Danis, Katarina Brennerova, Martina Skopkova, Timea Kurdiova, Jozef Ukropec, Juraj Stanik, Miriam Kolnikova and Daniela Gasperikova

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Camile Wunsch, Thais Fernanda Dornelles, Pricila Girardi, Marcelo Emilio Arndt, Julia Pasqualini Genro and Veronica Contini

. Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation. J Biol Chem 283, 8723–8735, 2008. Long J, Edwards T, Signorello LB, Cai Q, Zheng W, Shu XO, Blot WJ. Evaluation of genome-wide association study-identified type 2 diabetes loci in African Americans. Am J Epidemiol 176, 995–1001, 2012. Lyssenko V, Lupi R, Marchetti P, Del Guerra S, Orho-Melander M, Almgren P, Sjogren M, Ling C, Eriksson KF, Lethagen AL, Mancarella R, Berglund G, Tuomi T, Nilsson P, Del Prato S, Groop L. Mechanisms by which common

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Farhad Ghadiri Soufi, Ali Akbar Poursadegh Zonouzi, Ebrahim Eftekhar, Kamila Kamali, Sara Aghakhani Chegeni and Ahmad Poursadegh Zonouzi

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Open access

Terezia Valkovicova, Martina Skopkova, Juraj Stanik and Daniela Gasperikova

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Alexandra Padova, Ivana Rokytova, Boris Mravec, Richard Kvetnansky and Peter Vargovic

, Prescott SM, McIntyre TM. Retrograde inflammatory signaling from neutrophils to endothelial cells by soluble interleukin-6 receptor alpha. J Clin Invest 100, 2752–2756, 1997. Moraes CF, Lins TC, Carmargos EF, Naves JO, Pereira RW, Nobrega OT. Lessons from genome-wide association studies findings in Alzheimer’s disease. Psychogeriatrics 12, 62–73, 2012. Muller UC, Deller T, Korte M. Not just amyloid: physiological functions of the amyloid precursor protein family. Nat Rev Neurosci 18, 281–298, 2017. Murakami N, Yamaki T, Iwamoto Y, Sakakibara T, Kobori N

Open access

K. Voglova, J. Bezakova and Iveta Herichova

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Open access

L. Pecenova and Robert Farkas

, Istomin AY, Livesay DR, Jacobs DJ, Swerdloff RS, Miksovska J, Larsen RW, Bhasin S. Kinetic and thermodynamic characterization of dihydrotestosterone-induced conformational perturbations in androgen receptor ligand-binding domain. Mol Endocrinol 23, 1231-1241, 2009. Jones S. An overview of the basic helix-loop-helix proteins. Genome Biol 5, 226, 2004. Jung SY, Malovannaya A, Wei J, O’Malley BW, Qin J. Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes. Mol Endocrinol 19, 2451-2465, 2005

Open access

Laura M. L. Carvalho, Fernando M. dos Reis, Ana Lucia Candido, Fernanda F. C. Nunes, Claudia N. Ferreira and Karina B. Gomes

, Zhao H, Chen ZJ. Genome-wide association studies for Polycystic Ovary Syndrome. Semin Reprod Med 34, 224-229, 2016. Mackman N. The role of tissue factor and factor VIIa in hemostasis. Anesth Analg 108, 1447-1452, 2009. Macut D, Damjanovic S, Panidis D, Spanos N, Glisic B, Petakov M, Rousso D, Kourtis A, Bjekic J, Milic N. Oxidised low-density lipoprotein concentration - early marker of an altered lipid metabolism in young women with PCOS. Eur J Endocrinol 155, 131-136, 2006. Macut D, Bjekic-Macut J, Savic-Radojevic A

Open access

K. Voglova, J. Bezakova and Iveta Herichova

, Kondova I, Otting N, Koeppen AH, Bontrop RE. Genome-wide analysis of miRNA expression reveals a potential role for miR-144 in brain aging and spinocerebell arataxia pathogenesis. Neurobiol Aging 32, 2316. e17−27, 2011. http://dx.doi.org/10.1016/j.neurobiolaging.2010.03.014 Pigati L, Yaddanapudi SC, Iyengar R, Kim DJ, Hearn SA, Danforth D, Hastings ML, Duelli DM. Selective release of microRNA species from normal and malignant mammary epithelial cells. PLoS One 5, e13515, 2010. http://dx.doi.org/10.1371/journal.pone.0013515 Poliseno L