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Agnieszka Łaba-Stefanek, Ewelina Dziwota and Marcin Olajossy

badania asocjacyjne całego genomu (GWAS) wniosły do psychiatrii?, 2013. 8. Bergen S.E., Petryshen T.L. Genome-wide association studiem (GWAS) of schizophrenia: does bigger lead to better results?, 2013. 9. Hosak L., Silhan P., Hosakowa J. Genomic copy number variations: A breakthrough in our knowledge on schizophrenia etiology?, 2012. 10. Kotlar A.V., Mercer K.B., Zwick M.E., Mulle J.G. New discoveries in schizophrenia genetics reveal neurobiological pathways: A review of recent findings, 2015 11. Gumerov V., Hegyi H. MicroRNA-derived network

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Fatemeh Khatami, Mahsa Mohammadamoli and Seyed Mohammad Tavangar


Pheochromocytomas and paragangliomas (PPGLs) are tumors arising from the adrenal medulla and sympathetic/parasympathetic paraganglia, respectively. According to Th e Cancer Genome Atlas (TCGA), approximately 40% of PPGLs are due to germ line mutations in one of 16 susceptibility genes, and a further 30% are due to somatic alterations in at least seven main genes (VHL, EPAS1, CSDE1, MAX, HRAS, NF1, RET, and possibly KIF1B). Th e diagnosis of malignant PPGL was straight forward in most cases as it was defined as presence of PPGL in non-chromaffin tissues. Accordingly, there is an extreme need for new diagnostic marker(s) to identify tumors with malignant prospective. Th e aim of this study was to review all suggested genetic and epigenetic alterations that are remarkably different between benign and malignant PPGLs. It seems that more than two genetic mutation clusters in PPGLs and other genetic and methylation biomarkers could be targeted for malignancy discrimination in different studies.

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Daniel Danis, Katarina Brennerova, Martina Skopkova, Timea Kurdiova, Jozef Ukropec, Juraj Stanik, Miriam Kolnikova and Daniela Gasperikova

syndrome. Biochem Biophys Res Commun 497, 1043–1048, 2018. Martinelli D, Catteruccia M, Piemonte F, Pastore A, Tozzi G, Dionisi-Vici C, Pontrelli G, Corsetti T, Livadiotti S, Kheifets V, Hinman A, Shrader WD, Thoolen M, Klein MB, Bertini E, Miller G. EPI-743 reverses the progression of the pediatric mitochondrial disease-genetically defined Leigh Syndrome. Mol Genet Metab 107, 383–388, 2012. McLaren W, Gil L, Hunt SE, Riat HS, Ritchie GR, Thormann A, Flicek P, Cunningham F. The Ensembl Variant Effect Predictor. Genome Biol 17, 122, 2016. Paila U

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Camile Wunsch, Thais Fernanda Dornelles, Pricila Girardi, Marcelo Emilio Arndt, Julia Pasqualini Genro and Veronica Contini

. Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation. J Biol Chem 283, 8723–8735, 2008. Long J, Edwards T, Signorello LB, Cai Q, Zheng W, Shu XO, Blot WJ. Evaluation of genome-wide association study-identified type 2 diabetes loci in African Americans. Am J Epidemiol 176, 995–1001, 2012. Lyssenko V, Lupi R, Marchetti P, Del Guerra S, Orho-Melander M, Almgren P, Sjogren M, Ling C, Eriksson KF, Lethagen AL, Mancarella R, Berglund G, Tuomi T, Nilsson P, Del Prato S, Groop L. Mechanisms by which common

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Farhad Ghadiri Soufi, Ali Akbar Poursadegh Zonouzi, Ebrahim Eftekhar, Kamila Kamali, Sara Aghakhani Chegeni and Ahmad Poursadegh Zonouzi

References Aure MR, Leivonen SK, Fleischer T, Zhu Q, Overgaard J, Alsner J, Tramm T, Louhimo R, Alnæs GI, Perala M, Busato F, Touleimat N, Tost J, Børresen-Dale AL, Hautaniemi S, Troyanskaya OG, Lingjærde OC, Sahlberg KK, Kristensen VN. Individual and combined effects of DNA methylation and copy number alterations on miRNA expression in breast tumors. Genome Biol 14, R126, 2013. Bhattacharya S, Aggarwal R, Singh VP, Ramachandran S, Datta M. Downregulation of miRNAs during delayed wound healing in diabetes: Role of Dicer. Mol Med 2015. Chavali V

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Terezia Valkovicova, Martina Skopkova, Juraj Stanik and Daniela Gasperikova

annotation data. Bioinforma Appl NOTE 25, 288–289, 2009. Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, Holm H, Sanna S, Kavousi M, Baumeister SE, Coin LJ, Deng G, Gieger C, Heard-Costa NL, Hottenga JJ, Kuhnel B, Kumar V, Lagou V, Liang L, et al. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet 43, 1131–1138, 2011. Chi YI, Frantz JD, Oh BC, Hansen L, Dhe-Paganon S, Shoelson SE. Diabetes mutations delineate an atypical POU domain in HNF-1α. Mol Cell 10, 1129–1137, 2002. Chi YI

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Ewelina Dziwota, Urszula Fałkowska, Katarzyna Adamczyk, Dorota Adamczyk, Alena Stefańska, Justyna Pawęzka and Marcin Olajossy

. (2013) Systemic delivery of MeCP2 rescues behavioral and cellular deficits in female mouse models of Rett syndrome. J. Neurosci. 33, 13612–13620 42. Savic, N. and Schwank, G. (2015) Advances in therapeutic CRISPR/Cas9 genome editing. Transl. Res. Published online September 26, 2015. 43. Deffit, S.N. and Hundley, H.A. (2015) To edit or not to edit: regulation of ADAR editing specificity and efficiency. RNA Pub-lished online November 26, 2015. 44. Ricceri, L. et al

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Alexandra Padova, Ivana Rokytova, Boris Mravec, Richard Kvetnansky and Peter Vargovic

, Prescott SM, McIntyre TM. Retrograde inflammatory signaling from neutrophils to endothelial cells by soluble interleukin-6 receptor alpha. J Clin Invest 100, 2752–2756, 1997. Moraes CF, Lins TC, Carmargos EF, Naves JO, Pereira RW, Nobrega OT. Lessons from genome-wide association studies findings in Alzheimer’s disease. Psychogeriatrics 12, 62–73, 2012. Muller UC, Deller T, Korte M. Not just amyloid: physiological functions of the amyloid precursor protein family. Nat Rev Neurosci 18, 281–298, 2017. Murakami N, Yamaki T, Iwamoto Y, Sakakibara T, Kobori N

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K. Voglova, J. Bezakova and Iveta Herichova

-1134, 2007. Heo I, Joo C, Cho J, Ha M, Han J, Kim VN. Lin28 mediates the terminal uridylation of let-7 precursor Micro- RNA. Molecular Cell 32, 276-284, 2008. Holley CL, Topkara VK. An introduction to small non-coding RNAs: miRNA and snoRNA. Cardiovasc Drugs Th er 25, 151-159, 2011. http://dx.doi:10.1007/s10557-011-6290-z Hock J, Meister G. The Argonaute protein family. Genome Biol 9, 210, 2008.

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L. Pecenova and Robert Farkas

, Istomin AY, Livesay DR, Jacobs DJ, Swerdloff RS, Miksovska J, Larsen RW, Bhasin S. Kinetic and thermodynamic characterization of dihydrotestosterone-induced conformational perturbations in androgen receptor ligand-binding domain. Mol Endocrinol 23, 1231-1241, 2009. Jones S. An overview of the basic helix-loop-helix proteins. Genome Biol 5, 226, 2004. Jung SY, Malovannaya A, Wei J, O’Malley BW, Qin J. Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes. Mol Endocrinol 19, 2451-2465, 2005