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Regulation of Cough by Voltage-Gated Sodium Channels in Airway Sensory Nerves

. Nassenstein C, Taylor-Clark TE, Myers AC, Ru F, Nandigama R, Bettner W, Undem BJ. Phenotypic distinctions between neural crest and placodal derived vagal C-fibres in mouse lungs. J Physiol 2010; 588 (Pt 23): 4769-4783. 8. Hodes R. Linear relationship between fiber diameter and velocity of conduction in giant axon of squid. J Neurophysiol 1953; 16 (2): 145-154. 9. Canning BJ, Undem BJ. Evidence that distinct neural pathways mediate parasympathetic contractions and relaxations of guinea-pig trachealis. J Physiol 1993; 471: 25-40. 10. Canning BJ, Mazzone SB

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Histamine and its Effects Mediated via H3 Receptor – Potential Clinical Applications of H3 Antagonists

, Erlander MG. Cloning and Functional Expression of the Human Histamine H3 Receptor Mol Pharmacol 1999; 55: 1101-1107. 40. Bongers G, Bakker RA, Leurs R. Molecular aspects of the histamine H3 receptor. Biochem Pharmacol 2007; 73: 1195-1204. 41. Drutel G, Peitsaro N, Karlstedt K, Wieland K, Smit MJ, Timmerman H, Panula P, Leurs R. Identification of rat H3 receptor isoforms with different brain expression and signaling properties. Mol Pharmacol 2001; 59: 1-8. 42. Tardivel-Lacombe J, Rouleau A, Héron A, Morisset S, Pillot C

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Skin Tissue Surface Morphology and Quality of RNA and Protein Extracted from Fresh and Stabilized Human Cleft Lip and Palate Tissue

/mammal/epithelial.htm. Accessed July 25, 2013. 24. Brown IA. Scanning electron microscopy of human dermal fibrous tissue. J Anat. 1972: 113(2): 159-68. 25. Sawhney RK, Howard J. Slow local movements of collagen fibers by fibroblasts drive the rapid global self-organization of collagen gels. J Cell Biol. 2002: 157(6): 1083-92. 26. Ericsson C, Nistér M. Protein extraction from solid tissue.Methods Mol Biol. 2011: 675: 307-12. 27. Mutter GL, Zahrieh D, Liu C, et al. Comparison of frozen and RNALater solid

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25th Hellenic conference of Clinical Oncology

is the second most common type of cancer in the male population. Radiation therapy, however, causes a) injury to endothelial cells and smooth muscle fibers, b) rupture of smaller vessels in the area of ​the prostate and penis, c) subsequent vascular stenosis and arterial insufficiency, d) reduction of the cavernous nerve kinetic response, e) damage to peripheral nerve fibers, eventually leading to erectile dysfunction. Aim : To search for and summarize the therapeutic options for radiation-induced erectile dysfunction in prostate cancer patients, with a view to

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Podocyturia: What is in a name?


The podocyte is a highly differentiated cell located in the outer space of the glomerular basement membrane that deals with many different functions. This phylogenetically preserved cell that is responsible for the virtually absence of proteins in the urine lacks of the capacity to divide under normal conditions. When podocytes receive molecular insults, which normally occur during stress conditions as glomerulonephritis, hyperfiltration or metabolic disturbances, they adapt to the new situation by contracting their actin fibers. This adaptive behavior puts at risk the quality of the plasmatic filtration due to the denudation of the glomerular basement membrane, the potential mesangial inflammation and the appearance of proteinuria; podocytes run the risk of detachment from the basement membrane due to a decrease in the adherence to the surrounding matrix after contraction, a process called foot processes effacement. Podocytes change their shape and under constant mechanical stress they finally detach, rendering the glomerular basement membrane unprotected unless other contiguous podocytes are capable of covering the surface. However, these still anchored podocytes are generally also under the same stress situation and follow the same pathway. Podocyturia refers to the presence of these differentiated cells in the urinary sediment. Noteworthy, the podocytes that are encountered in the urine are viable despite the glomerular hostile environment and the urinary acidity. Podocyturia can precede proteinuria and can aggravate it. Therefore, in diseases that can threaten the glomerular normal environment, the presence and the quantification of urinary podocytes can be of remarkable relevance, as it can herald or accompany the appearance of proteinuria, and could offer another view to the interpretation and clinical approach and outcome of proteinuria. However, its identification needs a wide-spread training among biochemists and technicians, as well as commercially available kits.

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Molecular mechanisms involved in physical exercise and factors that may influence them. particularities in patients with type 2 diabetes mellitus

Henderson, Walter C Soeller, Michael Gibbs E, David E James and James D. Best. Identification of a novel glucose transporter-like protein-GLUT-12. American Journal of Physiology - Endocrinology, vol. 282 (3), E733-E738, 2002. 11. Gaster M, Poulsen P, Handberg A, Schroder HD, Beck-Nielsen H. Direct evidence of fiber typedependent GLUT-4 expression in human skeletal muscle. Am J Physiol Endocrinol Metab May; 278(5): E910-6, 2000. 12. Joslin’s Diabetes Mellitus. 14th Edition, Section II, Chapter 14, Biology of scheletal muscle , pg. 227

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The Effect of Tempeh Gembus Variations to Serum Levels of High Sensitivity C-Reactive Protein (hsCRP) and Serum Levels of Fibrinogen of Sprague Dawley Rats with Aterogenic Diet

. Sulchan M, Nur E . Nilai Gizi dan Komposisi Asam Amino Tempe Gembus serta Pengaruhnyaterhadap Pertumbuhan Tikus. Maj Kedokt Indon 57(3), 2007. 9. Kim JH, Jia Y, Lee JG, et al. Hypolipidemic and antiinflammation activities of fermented soybean fibers from meju in C57BL/6 J Mice. Phytother Res 28: 13553-41, 2014. 10. Kone OH. The Combined effects of genistein and daidzein on adipocyte differentiation 26, 2014 11. Muka T . Polyunsaturated Fatty Acids and Serum C-Reactive Protein. Am J Epidemiol 181(11): 846–856, 2015. 12. Bakhtiary A Yassin

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Gamma-enolase: a well-known tumour marker, with a less-known role in cancer

. McAlister L, Holland MJ. Targeted deletion of a yeast enolase structural gene. Identification and isolation of yeast enolase isozymes. J Biol Chem 1982; 257: 7181-8. 6. Diaz-Ramos A, Roig-Borrellas A, Garcia-Melero A, Lopez-Alemany R. Alpha-enolase, a multifunctional protein: its role on pathophysiological situations. J Biomed Biotechnol 2012; 2012: 156795. 7. Hattori T, Takei N, Mizuno Y, Kato K, Kohsaka S. Neurotrophic and neuro-protective effects of neuron-specific enolase on cultured neurons from embryonic rat brain. Neurosci Res 1995; 21: 191

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Role of Microbiome in Rheumatic Diseases

in their gut flora [ 4 ]. Feeding with breast-milk containing different milk microbiota and maternal antibodies is another way that may affect the development of their gut flora [ 4 ]. During growth, the composition of the gut microbiota are affected by individual’s lifestyle, diet, and medication use [ 4 ]. Westernized diet with high-saturated fatty acids and sucrose, and low fiber, promote epithelial inflammation and stimulate the pathogenic bacterial growth inside the gut [ 6 ]. Frequent use of the antibiotics further affects the healthy commensals growth and

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Protective/restorative role of the adipose tissue-derived mesenchymal stem cells on the radioiodine-induced salivary gland damage in rats

. Electron microscopy findings TEM demonstrated cellular damage and fibrosis ( Figure 2C - D ). Intercellular edema and intracellular vacuolization showed cellular damage. Figure 2 The figure (magnification × 5000) demonstrates the findings of electron microscopy at months 1 and 6. ( A and B ). Normal salivary gland samples of the control group. A and D . Intracellular vacuoles and intercellular edema related to radioiodine in Group 1. E and F . We observed intracellular vacuoles, intercellular edema, nucleus of fibroblast and collagen fibers (fibrosis) at 1

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