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Transient bioimpedance monitoring of mechanotransduction in artificial tissue during indentation

, presumably due to an outward flux of cross-linking ions into the surrounding medium [ 101 ], at large strains the degradation of the cross-links in the alginate is being accelerated and that the calcium ions released are affecting the cell behaviour [ 102 , 103 , 104 ]. The oscillation observed in the resistivity as shown in Fig. 15 are reminiscent of typical action potential including a depolarization, repolarization and refractory stage [ 105 ]. The delay in the response may be due to the temporal dynamics of Ca 2+ signalling events in fibroblasts which involve a

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