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Association of Mitochondrial DNA Variants and Cognitive Impairment of Phenylketonuria Patients / POVEZANOST VARIJANTI U MITOHONDRIJALNOJ DNK I KOGNITIVNOG FENOTIPA KOD PACIJENATA SA FENILKETONURIJOM

, Torroni A, et al. Mitochondrial DNA sequence diversity in bipolar affective disorder. Am J Psychiatry 2000; 157: 1058-64. 29. Kato T, Kunugi H, Nanko S, Kato N. Mitochondrial DNA polymorphisms in bipolar disorder. J Affect Disord 2001; 62: 151-64. 30. Kazuno AA, Munakata K, Nagai T, Shimozono S, Tanaka M, Yoneda M, et al. Identification of mitochondrial DNA polymorphisms that alter mitochondrial matrix pH and intracellular calcium dynamics. PLoS Genet 2006; 2: e128. 31. Kulawiec M, Owens KM, Singh KK. mtDNA Gm.10398A

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Platelet glutamate dehydrogenase activity and efficacy of antipsychotic therapy in patients with schizophrenia

loss of absorption of NADH recorded by spectrophotometry at 340 nm for 3 min. To calculate the enzymatic activity, the value of the molar extinction coefficient of NADH, 6.22×10 -3 l×mol -1 ×cm -1 was taken, and the specific activity of GDH per 1 mg of protein is given in Figures 1 and 2 . Figure 1 GDH activity in patients with schizophrenia (SZ) before (baseline) and after the treatment course. Figure 2 Dynamics of GDH activity for patients with baseline GDH activity below the median. Protein concentration was determined by the Lowry

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