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Review article. Strategies for in vivo targeted gene silencing

. 2007; 18:1391-6. Epub 2007 Jul 14. 32. Dohmen C, Wagner E. Multifunctional CPP polymer system for tumor-targeted pDNA and siRNA delivery. Methods Mol Biol. 2011; 683:453-63. 33. Kim SW, Kim NY, Choi YB, Park SH, Yang JM, Shin S. RNA interference in vitro and in vivo using an arginine peptide/siRNA complex system.J Control Release. 2010; 143:335-43. Epub 2010 Jan 14. 34. Meade BR, Dowdy SF. Exogenous siRNA delivery using peptide transduction domains/cell penetrating peptides. Adv Drug Deliver Rev. 2007; 59:134-40. Epub

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Long-acting injectable antipsychotics in patients with schizophrenia: systematic review and mixed treatment meta-analysis

study was to compare three competing risk outcomes of multiple LAIs antipsychotics available in Thailand for subjects with schizophrenia by using mixed treatment comparison meta-analysis. Three competing risk outcomes were number of relapses, discontinuation because of intolerable adverse events, and discontinuation because of other reasons. Systematic review of randomized controlled trials (RCT) was applied. The outcome of this study was planned to support our economic evaluation of LAIs at the next stage. Method Search We conducted a search strategy using

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A folic acid-induced rat model of renal injury to identify biomarkers of tubulointerstitial fibrosis from urinary exosomes

Fetuin-A identified by proteomics: a novel urinary biomarker for detecting acute kidney injury Kidney Int 2006 70 1847 57 19 Elias JE, Gygi SP. Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. Nature Methods. 2007; 4:207-14. 10.1038/nmeth1019 Elias JE Gygi SP Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry Nature Methods 2007 4 207 14 20 Leelahavanichkul A, Yan Q, Hu X, Eisner C, Huang Y, Chen R, et al. Angiotensin II

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Cost-effectiveness analysis of highly concentrated n-3 polyunsaturated fatty acids in secondary prevention after myocardial infarction

were life-long calculation. The provider perspective was chosen for this study; thus only direct health care costs were used in the analysis. Effectiveness data We carried out a meta-analysis to estimate the effectiveness of n-3 PUFAs for the base case analysis. A comprehensive literature search of MEDLINE, EMBASE, and the Cochrane Library (up to September 2013) was conducted. All trials that met the following criteria were included: 1) the trial enrolled adult patients (aged at least 18 years) with a history of myocardial infarction; 2) n-3 PUFAs were consumed

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The development and application of the ABCDE-health literacy scale for Thais

Figure 1 . Figure 1 The measurement model with the 3 levels of HL that effect health outcomes Synthesis of the HL index 1. An HL index was synthesized after a systematic literature review beginning with a review of all related research and evidence-based data through a keyword search for example, HL and model, and HL conceptual framework, using the PubMed and Science Direct databases to read the text of selected abstracts. The procedures for the research selection were as shown in Figure 2 . Figure 2 Flow of the process of research selection

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Analysis in silico of the single nucleotide polymorphism G–152A in the promoter of the angiotensinogen gene of Indonesian patients with essential hypertension

promoter of the DNA from 100 patients that we analyzed. The search revealed that the G/A allele at position –152 constituted the 2 genetic variations of the HIF-1-binding site. Figure 4 Polymerase chain reaction (PCR) products. Agarose gel (1.5%) electrophoresis showing a 593 bp band for 8 PCR products after amplification of AGT ; presented is AGT in the promoter area; M: Invitrogen TrackIt 100 bp DNA Ladder (Thermo Fisher Scientific). Figure 5 The single nucleotide polymorphism (SNP) G–152A of AGT (rs11568020) by direct sequencing. Electropherograms

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Human immunodeficiency virus and acquired immune deficiency syndrome in Asia: an update

immunodeficiency virus (HIV)-incidence by age group calculated by the Kaplan-Meier method, in a cohort of men who have sex with men from Bangkok from 2006-2012 [ 7 ]. In some countries such as Cambodia and Thailand, antenatal screening and prevention of mother to child transmission (PMCT) programmes have been very effective in reducing new HIV infections among children. However, regional PMCT program coverage is only 19%, and women may only receive single dose nevirapine, rather than WHO recommended combination antiretroviral therapy (ART) [ 3 ]. Migrant workers who move

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Isolation and polymerase chain reaction identification of bacteria from the 2014–2015 flood of Kota Bharu, Kelantan, Malaysia

Flood waters can be devastating, especially if proactive measures are not adequately taken ahead of time to mitigate the effects of the flood. In addition to the direct impact of flood water is the transmission of waterborne, foodborne, and airborne infection sequelae. Most of these infections are caused by pathogenic and opportunistic bacteria carried in the water from one location to another and include salmonellosis, leptospirosis, shigellosis, staphylococcus infections, burkholderiosis, vibriosis, and other infections [ 1 , 2 ]. Different bacteria have

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Practice of iron chelation therapy for transfusion-dependent thalassemia in Southeast Asia

as a first line therapy because its efficiency and safety in treating iron overload has been established. A patient’s compliance to this drug needs to be monitored as some patients do not comply with this treatment because of the inconvenience of the parenteral method of administration, which is time consuming [ 15 , 24 ]. The clinician will ultimately consider whether there is a need to change to another chelator or a combination therapy. In the absence of iron chelation therapy, iron will continue to accumulate in the patient’s organs leading to clinical

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Review of the role of basic fibroblast growth factor in dental tissue-derived mesenchymal stem cells

multipotential differentiation ability [ 14 - 16 ]. Although these cells share common characters, the DMSCs from different sources exhibit dissimilar characteristics and potency [ 17 - 20 ]. Various studies have examined the effect of bFGF on the behavior of these DMSCs. The results are varied. In the present article, the influence of bFGF on DMSCs is reviewed and discussed in terms of both stemness maintenance and cell differentiation. Methods The articles from January 1, 1990 to March 25, 2015 in PubMed database were searched using keywords. The keywords used in the

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