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George Fotopoulos, Ioannis Vathiotis, George C. Nikou and Konstantinos Syrigos

mutations in this setting and to explore the possible use of them in diagnosis, prognosis and management, if any apply. Two debated terminologies have risen in the recent years, with the use of the term endocrine versus neuroendocrine and that of neoplasms instead of tumors. Also well differentiated gastrointestinal NETs are also termed carcinoid tumors. For the sake of uniformity in this paper the term NETs will be used Material and Methods A literature search was performed with end-date June 2016 and a year span of the last ten years. The following algorithm

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General Hospital of N. Ionia, Athens Introduction : Providing relief to the elderly with cancer is now imperative as the global population is getting older, and health professionals are being urged to cope with a multitude of patient problems based on palliative care principles. Aim : To highlight the special issues of palliative care in elderly patients with cancer. Methods : Bibliography was reviewed through the google scholar search engine and the «Pubmed» electronic database under the terms: Palliative care, aged, hospice, elderly, holistic, in English

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Georgios Lypas

Introduction A diagnosis of cancer is very often accompanied by several questions both from the patients and the physicians. “Why me?” is a question routinely phrased by most patients, reflecting not only a psychological distress but also a genuine search for an explanation on the causes of their disease. The largest percentage of them may not receive a concrete answer for this question. Still, for a small, but not a negligible portion, the cause will be concerned with an inherited cancer predisposition. In many, but not all families, this predisposition is

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Nikolaos F. Pistamaltzian, Sonia A. Perez and Constantin N. Baxevanis

evidence of cross priming with other tumour antigens, which can act as possible candidates for further testing. The administration was safe and well tolerated with only mild side effects [ 54 – 56 ]. This is also the method for the HER2-based breast cancer vaccine lapuleucel-T (Neuvenge, Dendreon Corp), which has been used in early clinical trials [ 57 ]. Another DC vaccine approach being explored in breast cancer uses leukapheresed APCs (antigen presenting cells) transfected with a replication of defective adenoviral vector loaded with wild-type p53 transcript [ 58

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Simone Ribero, Eugenio Sportoletti Baduel, Matteo Brizio, Franco Picciotto, Emi Dika, Maria Teresa Fierro, Giuseppe Macripò and Pietro Quaglino

) classification as more at risk of involved margins after surgery in squamous cell carcinoma. 13 Methods A systematic literature review for case reports of extra-ocular, cutaneous, multifocal metastasizing SC in the time between 1960 and 2015 was conducted. We therefore searched the literature for all cases mentioning a skin directed therapy and response results for metastatic sebaceous carcinoma utilizing PubMed’s MEDLINE database. Results Local and distant cutaneous/subcutaneous metastases were described in the course of disease in 8 cases ( Table 1 ). 14 - 21

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Đeni Smilovic Radojcic, David Rajlic, Bozidar Casar, Manda Svabic Kolacio, Nevena Obajdin, Dario Faj and Slaven Jurkovic

Introduction The accuracy of dose calculation and precise dose delivery are crucial factors in the radiotherapy treatment process. There is a common agreement that Monte Carlo (MC) simulation is the most promising method for accurate calculation of absorbed dose. 1 , 2 In MC based systems the absorbed dose calculated to be delivered by external photon beams can be reported either as dose-to-media (D m ) or dose-to-water (D w ), and there is still no general agreement regarding the choice of the calculation method. 1 , 2 , 3 Hence, experimental

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Luca G. Campana, A. James P. Clover, Sara Valpione, Pietro Quaglino, Julie Gehl, Christian Kunte, Marko Snoj, Maja Cemazar, Carlo R. Rossi, Damijan Miklavcic and Gregor Sersa

higher quality and standardization of reported studies is needed to improve and support a truly evidence based practice. In our study we only included papers published after 2006, specifically only to include reports published after the Standard Operating Procedures (SOP). 24 Figure 1. Search in Web of Science demonstrates a steady increase in number of publications under the key word “electrochemotherapy” (A,B) as well under the “electrochemotherapy, clinical” (C,D). The Meta data indicate the expanding field. The purpose of this recommendation paper

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Martina Vrankar and Mojca Unk

highlighted in iRECIST regarding pseudoprogression. Worsening of clinical and performance status (PS) should not be accompanied with pseudoprogression since it most probably reflects the true progression of the malignancy. 7 Here we present the single institution experience of symptomatic pseudoprogression after one application of anti PD-L1 therapy in a patient with metastatic NSCLC followed by dramatic treatment response to immunotherapy and report on the review of symptomatic pseudoprogressions from literature. Methods A systematic review of the literature was

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Marco Giovanni Persico, Federica Eleonora Buroni, Francesca Pasi, Lorenzo Lodola, Carlo Aprile, Rosanna Nano and Marina Hodolic

in comparison to values previously reported for 18 F-FDG. 2 A thorough literature search did not find any studies with direct comparisons between 18 F-FCH and 18 F-FET uptake in glioma cell cultures. However, papers related to in vivo uptake in experimental rat gliomas indicate a higher accumulation of 18 F-FET in terms of Standard Uptake Value (SUV) as seen in both transplanted C6 28 or F98 glioma models 29 , 30 in comparison to radio-labelled choline. Despite the different amounts of 18 F-FCH and 18 F-FET taken up by the same cell culture, the in vitro

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Uros Smrdel, Marija Skoblar Vidmar and Ales Smrdel

patients either to radical treatment with radiochemotherapy with adjuvant temozolomide, palliative radiotherapy or supportive care. Since the methylation status in patients over 70, is now routinely determined, and the patients are now being offered treatment also on the basis of it, we have analysed our results of the past years, with the aim of obtaining our population data, so that it could serve as a benchmark for assessment of the further treatment strategies in this group of patients. Patients and methods Between the 1997 and the end of 2015, 1019 patients