Tomaz Jagric, Stojan Potrc, Katarina Mis, Mojca Plankl and Tomaz Mars
micrometastases and preoperative CA19-9 serum levels to determine the cut-off level for micrometastases detection, along with the respective sensitivities and specificities. Finally, the prognostic value of this cut-off for CA19-9 serum levels was investigated for a group of patients with node-negative gastric cancer.
Patients and methods
Between 1992 and 2013, a total of 1,129 patients underwent surgery for gastric cancer at the University Clinical Centre Maribor, Slovenia. From these, only node-negative patients with complete clinicopathological records and
Qingxin Meng, Weiwei Ding, Bin Yang, Ninghua Fu and Guangming Lu
parameters in the diagnosis of renal artery stenosis: a study to validate and optimize cut-off points. Arq Bras Cardiol 2006; 87 : 321-8.
Kawarada O, Yokoi Y, Takemoto K, Morioka N, Nakata S, Shiotani S. The performance of renal duplex ultrasonography for the detection of hemodynamically significant renal artery stenosis. Catheter Cardiovasc Interv 2006; 68 : 311-8.
Smet AA, Ermers EJ, Kitslaar PJ. Duplex velocity characteristics of aortoiliac stenoses. J Vasc Surg 1996; 23 : 628
Marija Marcan, Denis Pavliha, Maja Marolt Music, Igor Fuckan, Ratko Magjarevic and Damijan Miklavcic
interwoven 3d tubular tree structures utilizing shape priors and graph cuts. Med Image Anal 2010; 14: 172-84.
32 Shang Q, Clements L, Galloway RL, Chapman WC, Dawant BM. Adaptive directional region growing segmentation of the hepatic vasculature. In: Reinhardt JM, Pluim JPW, editors. Proceedings of SPIE. Volume 6914. SPIE; 2008. p. 69141F-10.
33 Beichel R, Pock T, Janko C, Zotter RB, Reitinger B, Bornik A, et al. Liver segment approximation in CT data for surgical resection planning. In: Fitzpatrick JM, Sonka M, editors. Proceedings of
Lorna Zadravec Zaletel, Matjaz Popit and Marjan Zaletel
possible screening tools in the future could be PWV, but further research in this field is needed. What is more, even a very low dose of RT can cause atherosclerotic changes, therefore we should change cut-off dose of 40 Gy to a lower one. However, it is beyond dispute that atherogenesis in LTSCC with controlling cardiovascular risk factors can be slowed down. This is very important because it was reported that LTSCC are predisposed to obesity, hypertension, dyslipidaemia and glucose intolerance 16 , 17 , therefore carefully monitoring and correction of the common
Kursat Okuyucu, Sukru Ozaydın, Engin Alagoz, Gokhan Ozgur, Semra Ince, Fahrettin Guven Oysul, Ozlem Ozmen, Murat Tuncel, Mustafa Ozturk and Nuri Arslan
analysis. The results of univariate and multivariate Cox regression analyses are shown in Table 2 , 3 . ROC curve drawn to evaluate the diagnostic value of SUVmean, MTV and TLG is shown in Figure 1 . SUVmean remained significant after ROC curve analysis. One unit increment of SUVmean amplifies recurrence rate 1.4 times. Sensitivity and specificity were calculated as 88% and 64%, respectively, when the cut-off value of SUVmean was set at 5.15. Cut-off values, sensitivity and specificity of SUVmean, MTV and TLG are shown in Table 4 . SUVmean was dichotomized by
Roberta Fusco, Mario Petrillo, Vincenza Granata, Salvatore Filice, Mario Sansone, Orlando Catalano and Antonella Petrillo
and DWI tumour volume reduction were the best predictors of complete pathological response. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of DWI visual assessment to predict complete response were 81.8%, 94.3%, 75%, 96.1% and 76% respectively. Sensitivity, specificity and accuracy of tumour volume reduction (cutoff value 95%) were 80%, 84.1% and 64.1%, respectively.
ADC measure (before, during, and after therapy) is the most widely studied approach to assess therapy response. Increases in ADC values after treatment
Zsolt Levente Janvary, Nicolas Jansen, Veronique Baart, Magali Devillers, David Dechambre, Eric Lenaerts, Laurence Seidel, Nicole Barthelemy, Patrick Berkovic, Akos Gulyban, Ferenc Lakosi, Zsolt Horvath and Philippe A. Coucke
reported comparable results (3-year LC rate of 80%) in a large cohort study of central and peripheral metastases of 87 pts (189 lesions).
Although the distribition of patient numbers at the different dose-levels was particularly inbalanced in our cohort, analysis was performed on effect of BED 10Gy on LC. A clear correlation between the applied dose and the actuarial local control rates were found with a cut-off at BED 10Gy of 112.5 Gy, where lower doses were associated with higher rates of local recurrence. Local control rates at 1, 2, and 3 years were 93% vs 73
different treatment groups due to small number of patients in each group and consequently a low power of the test.
The influence of positive lymph nodes, ECE, size of primary tumour and completeness of surgical resection on survival and LC were analysed. Arbitrary cutoff points for positive lymph nodes and ECE (negative versus positive), size of primary tumour (up to 4 cm versus ≥ 4 cm) and completeness of surgical resection (complete R0 versus incomplete R1/R2) were used.
The data regarding the side effects of the radiotherapy treatment or surgery were not
Mahdi Ghorbani, Benyamin Khajetash, Najmeh Ghatei, Mohammad Mehrpouyan, Ali S. Meigooni and Ramin Shahraini
, the spherical tally cells were placed at distances ranging from 1 to 40 cm from the source center at 1 cm intervals. These spheres were made of air and their radii were defined according to a joint report from AAPM and European Society for Therapeutic Radiology and Oncology (ESTRO). 22 The amount of air kerma was scored by F6 tally (in terms of MeV/g). Throughout this project the energy cutoff for photons and electrons was defined as 1 keV. Each simulation was performed for 1.4 × 10 9 particles and the maximum type A uncertainty of Monte Carlo simulation in these
. 35 In addition, a more recent study suggests that thresholds differ between low-(Grade Group 1–2) and high-grade (Grade Group 3–5) cancers, with the former having a positive predictive values (PPV) of 90.4% for ECE at 12.5 mm and the optimal cut-off for the latter being 5 mm. 26 This finding was further confirmed by Matsuoka et al . who reported significantly increased upstaging in low- versus high-grade cancers when the same threshold (10 mm) was applied. 44 Given that lower apparent diffusion coefficient (ADC) values in prostate cancer correlate with higher