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25th Hellenic conference of Clinical Oncology

side effects during as well as post Everolimus treatment. TUMOR MUTATIONAL BURDEN (TMB): DETERMINATION, CUT-OFFS AND ITS EMERGING IMPORTANCE IN IMMUNOTHERAPIES Tsaousis G. 1 , Papadopoulou E. 1 , Fotiou D. 1 , Tsantikidi K. 1 , Metaxa-Mariatou V. 1 , Stamou E. 1 , Floros T. 2 , Trafalis D. 3 , Anagnostopoulos A. 3 , Fassas A. 4 , Diamantidou E. 5 , Giassas S. 6 , Andreadis X. 7 , Gkioulmpasanis I. 8 , Tsiatas M. 9 , Tzaninis D. 9 , Nasioulas G. 1 1 Genekor Medical SA, Athens, Greece 2 Athens Naval and Veterans Hospital, Athens, Greece 3 Errikos

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CA19-9 serum levels predict micrometastases in patients with gastric cancer

micrometastases and preoperative CA19-9 serum levels to determine the cut-off level for micrometastases detection, along with the respective sensitivities and specificities. Finally, the prognostic value of this cut-off for CA19-9 serum levels was investigated for a group of patients with node-negative gastric cancer. Patients and methods Between 1992 and 2013, a total of 1,129 patients underwent surgery for gastric cancer at the University Clinical Centre Maribor, Slovenia. From these, only node-negative patients with complete clinicopathological records and

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Analysis of peripheral artery velocity tracing in a porcine model

parameters in the diagnosis of renal artery stenosis: a study to validate and optimize cut-off points. Arq Bras Cardiol 2006; 87 : 321-8. Kawarada O, Yokoi Y, Takemoto K, Morioka N, Nakata S, Shiotani S. The performance of renal duplex ultrasonography for the detection of hemodynamically significant renal artery stenosis. Catheter Cardiovasc Interv 2006; 68 : 311-8. Smet AA, Ermers EJ, Kitslaar PJ. Duplex velocity characteristics of aortoiliac stenoses. J Vasc Surg 1996; 23 : 628

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Segmentation of hepatic vessels from MRI images for planning of electroporation-based treatments in the liver

interwoven 3d tubular tree structures utilizing shape priors and graph cuts. Med Image Anal 2010; 14: 172-84. 32 Shang Q, Clements L, Galloway RL, Chapman WC, Dawant BM. Adaptive directional region growing segmentation of the hepatic vasculature. In: Reinhardt JM, Pluim JPW, editors. Proceedings of SPIE. Volume 6914. SPIE; 2008. p. 69141F-10. 33 Beichel R, Pock T, Janko C, Zotter RB, Reitinger B, Bornik A, et al. Liver segment approximation in CT data for surgical resection planning. In: Fitzpatrick JM, Sonka M, editors. Proceedings of

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Is carotid stiffness a possible surrogate for stroke in long-term survivors of childhood cancer after neck radiotherapy?

possible screening tools in the future could be PWV, but further research in this field is needed. What is more, even a very low dose of RT can cause atherosclerotic changes, therefore we should change cut-off dose of 40 Gy to a lower one. However, it is beyond dispute that atherogenesis in LTSCC with controlling cardiovascular risk factors can be slowed down. This is very important because it was reported that LTSCC are predisposed to obesity, hypertension, dyslipidaemia and glucose intolerance 16 , 17 , therefore carefully monitoring and correction of the common

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Prognosis estimation under the light of metabolic tumor parameters on initial FDG-PET/CT in patients with primary extranodal lymphoma

analysis. The results of univariate and multivariate Cox regression analyses are shown in Table 2 , 3 . ROC curve drawn to evaluate the diagnostic value of SUVmean, MTV and TLG is shown in Figure 1 . SUVmean remained significant after ROC curve analysis. One unit increment of SUVmean amplifies recurrence rate 1.4 times. Sensitivity and specificity were calculated as 88% and 64%, respectively, when the cut-off value of SUVmean was set at 5.15. Cut-off values, sensitivity and specificity of SUVmean, MTV and TLG are shown in Table 4 . SUVmean was dichotomized by

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Magnetic resonance imaging evaluation in neoadjuvant therapy of locally advanced rectal cancer: a systematic review

and DWI tumour volume reduction were the best predictors of complete pathological response. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of DWI visual assessment to predict complete response were 81.8%, 94.3%, 75%, 96.1% and 76% respectively. Sensitivity, specificity and accuracy of tumour volume reduction (cut off value 95%) were 80%, 84.1% and 64.1%, respectively. ADC measure (before, during, and after therapy) is the most widely studied approach to assess therapy response. Increases in ADC values after treatment

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Clinical outcomes of 130 patients with primary and secondary lung tumors treated with Cyberknife robotic stereotactic body radiotherapy

reported comparable results (3-year LC rate of 80%) in a large cohort study of central and peripheral metastases of 87 pts (189 lesions). Although the distribition of patient numbers at the different dose-levels was particularly inbalanced in our cohort, analysis was performed on effect of BED 10Gy on LC. A clear correlation between the applied dose and the actuarial local control rates were found with a cut-off at BED 10Gy of 112.5 Gy, where lower doses were associated with higher rates of local recurrence. Local control rates at 1, 2, and 3 years were 93% vs 73

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Long term results of radiotherapy in vulvar cancer patients in Slovenia between 1997–2004

different treatment groups due to small number of patients in each group and consequently a low power of the test. The influence of positive lymph nodes, ECE, size of primary tumour and completeness of surgical resection on survival and LC were analysed. Arbitrary cut off points for positive lymph nodes and ECE (negative versus positive), size of primary tumour (up to 4 cm versus ≥ 4 cm) and completeness of surgical resection (complete R0 versus incomplete R1/R2) were used. The data regarding the side effects of the radiotherapy treatment or surgery were not

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Determination of dosimetric parameters for shielded 153Gd source in prostate cancer brachytherapy

, the spherical tally cells were placed at distances ranging from 1 to 40 cm from the source center at 1 cm intervals. These spheres were made of air and their radii were defined according to a joint report from AAPM and European Society for Therapeutic Radiology and Oncology (ESTRO). 22 The amount of air kerma was scored by F6 tally (in terms of MeV/g). Throughout this project the energy cut off for photons and electrons was defined as 1 keV. Each simulation was performed for 1.4 × 10 9 particles and the maximum type A uncertainty of Monte Carlo simulation in these

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