side effects during as well as post Everolimus treatment.
TUMOR MUTATIONAL BURDEN (TMB): DETERMINATION, CUT-OFFS AND ITS EMERGING IMPORTANCE IN IMMUNOTHERAPIES
Tsaousis G. 1 , Papadopoulou E. 1 , Fotiou D. 1 , Tsantikidi K. 1 , Metaxa-Mariatou V. 1 , Stamou E. 1 , Floros T. 2 , Trafalis D. 3 , Anagnostopoulos A. 3 , Fassas A. 4 , Diamantidou E. 5 , Giassas S. 6 , Andreadis X. 7 , Gkioulmpasanis I. 8 , Tsiatas M. 9 , Tzaninis D. 9 , Nasioulas G. 1
1 Genekor Medical SA, Athens, Greece
2 Athens Naval and Veterans Hospital, Athens, Greece
Tomaz Jagric, Stojan Potrc, Katarina Mis, Mojca Plankl and Tomaz Mars
micrometastases and preoperative CA19-9 serum levels to determine the cut-off level for micrometastases detection, along with the respective sensitivities and specificities. Finally, the prognostic value of this cut-off for CA19-9 serum levels was investigated for a group of patients with node-negative gastric cancer.
Patients and methods
Between 1992 and 2013, a total of 1,129 patients underwent surgery for gastric cancer at the University Clinical Centre Maribor, Slovenia. From these, only node-negative patients with complete clinicopathological records and
Gianluca Rigatelli, Marco Zuin, Alan Fong, Truyen TTT Tai and Thach Nguyen
Effects of coronary stenting techniques are generally investigated regarding wall shear stress (WSS) or turbulence of flow at the lesion or bifurcation sites. [ 1 , 2 ] Recently, we speculated that ostial left main (LM) stenting potentially induces turbulence in the aortic wall near to the LM ostium. [ 3 ] Potential impact on the ascending aorta and arch have never been evaluated despite the fact that it would be logical that any turbulence induced outside the coronary tree can propagate at a certain distance within the aortic vasculature
Qingxin Meng, Weiwei Ding, Bin Yang, Ninghua Fu and Guangming Lu
parameters in the diagnosis of renal artery stenosis: a study to validate and optimize cut-off points. Arq Bras Cardiol 2006; 87 : 321-8.
Kawarada O, Yokoi Y, Takemoto K, Morioka N, Nakata S, Shiotani S. The performance of renal duplex ultrasonography for the detection of hemodynamically significant renal artery stenosis. Catheter Cardiovasc Interv 2006; 68 : 311-8.
Smet AA, Ermers EJ, Kitslaar PJ. Duplex velocity characteristics of aortoiliac stenoses. J Vasc Surg 1996; 23 : 628
Gianluca Rigatelli, Marco Zuin, Fabio Dell’Avvocata, Aravinda Nanjundappa, Ramesh Daggubati and Thach Nguyen
. Through a cut-out, the obtained ring of the stent was propagated axially to create the full-length, expanded model. In our models, the artery walls and plaque components were assumed to be isotropic, linear and elastic with a constant Young’s modulus ( E ), density and Poisson’s ratio. For stent simulation, devices were modelled as a shell-type tube; the mechanical properties such as density and Poisson’s ratio were in accordance with the reported technical properties of the stent. The arterial wall thickness was considered to be constant at 0.5 mm. A 3-D reconstruction
Marija Marcan, Denis Pavliha, Maja Marolt Music, Igor Fuckan, Ratko Magjarevic and Damijan Miklavcic
interwoven 3d tubular tree structures utilizing shape priors and graph cuts. Med Image Anal 2010; 14: 172-84.
32 Shang Q, Clements L, Galloway RL, Chapman WC, Dawant BM. Adaptive directional region growing segmentation of the hepatic vasculature. In: Reinhardt JM, Pluim JPW, editors. Proceedings of SPIE. Volume 6914. SPIE; 2008. p. 69141F-10.
33 Beichel R, Pock T, Janko C, Zotter RB, Reitinger B, Bornik A, et al. Liver segment approximation in CT data for surgical resection planning. In: Fitzpatrick JM, Sonka M, editors. Proceedings of
Lorna Zadravec Zaletel, Matjaz Popit and Marjan Zaletel
possible screening tools in the future could be PWV, but further research in this field is needed. What is more, even a very low dose of RT can cause atherosclerotic changes, therefore we should change cut-off dose of 40 Gy to a lower one. However, it is beyond dispute that atherogenesis in LTSCC with controlling cardiovascular risk factors can be slowed down. This is very important because it was reported that LTSCC are predisposed to obesity, hypertension, dyslipidaemia and glucose intolerance 16 , 17 , therefore carefully monitoring and correction of the common
Kursat Okuyucu, Sukru Ozaydın, Engin Alagoz, Gokhan Ozgur, Semra Ince, Fahrettin Guven Oysul, Ozlem Ozmen, Murat Tuncel, Mustafa Ozturk and Nuri Arslan
analysis. The results of univariate and multivariate Cox regression analyses are shown in Table 2 , 3 . ROC curve drawn to evaluate the diagnostic value of SUVmean, MTV and TLG is shown in Figure 1 . SUVmean remained significant after ROC curve analysis. One unit increment of SUVmean amplifies recurrence rate 1.4 times. Sensitivity and specificity were calculated as 88% and 64%, respectively, when the cut-off value of SUVmean was set at 5.15. Cut-off values, sensitivity and specificity of SUVmean, MTV and TLG are shown in Table 4 . SUVmean was dichotomized by
significantly more frequent in patients with underlying vasculitis when comparing with healthy individuals.
Other imaging techniques such as Doppler ultrasound had been reported useful in assessing the carotid arteries. Otherwise, fluorodeoxyglucose positron emission tomography (FDG-PET) had also been supported by a Japanese study for its role at initial diagnosis and monitoring of vascular activity in various causes of vascular inflammation [ 8 ]. In this study, with a cut-off standardized uptake value (SUV) at 2.1, the sensitivity and specificity of FDG-PET was 92.6% and
the Rheumatic Diseases 2009 68 1811 1818
 Machado P, Landewé R, Lie E, et al Ankylosing Spondylitis Disease Activity Score (ASDAS): defining cut-off values for disease activity states and improvement scores. Annals of the Rheumatic Diseases 2011;70:47-53.) 10.1136/ard.2010.138594 21068095
Machado P Landewé R Lie E et al Ankylosing Spondylitis Disease Activity Score (ASDAS): defining cut-off values for disease activity states and improvement scores Annals of the Rheumatic Diseases 2011 70 47 53