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Varga Réka-Izabella and Kovács Judit

-of-hospital cardiac arrest outcomes in 27 countries in Europe. Resuscitation . 2016,105:188-194. 4. Kleinman ME, Goldberger ZD, Rea T, Swor RA, Bobrow BJ, Brennan EE et al. 2017 American Heart Association Focused Update on Adult Basic Life Support and Cardiopulmonary Resuscitation Quality: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation . 2018,137:e7-e13 5. Chair SY, Hung MS, Lui JC, Lee DT, Shiu IY, Choi KC. Public knowledge and attitudes towards cardiopulmonary resuscitation in

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Ján Bystriansky, Ján Burkuš, Štefan Juhás, Dušan Fabian and Juraj Koppel

Abstract

High plasma urea nitrogen concentration has been proposed as an important factor contributing to the decline in reproductive parameters of domestic animals. The aim of this study was to evaluate the effect of urea on the development of preimplantation embryos in a mouse model. During in vivo tests, acute renal failure (ARF) accompanied by hyper-uraemia was induced by intramuscular administration of glycerol (50%) into hind limbs of fertilised dams. During in vitro tests, embryos collected from healthy dams were cultured in a medium with the addition of various concentrations of urea from the 4-cell stage to the blastocyst stage. Stereomicroscopic evaluation and fluorescence staining of embryos obtained from dams with ARF showed that high blood urea is connected with an increase in the number blastocysts containing at least one apoptotic cell and in the incidences of dead cells per blastocyst, but it did not affect their ability to reach the blastocyst stage. In vitro tests showed that culture of embryos with urea at concentration of 10 mM negatively affected the quality of obtained blastocysts. Blastocysts showed significantly lower numbers of cells and increased incidence of dead cells. An increase in apoptosis incidence was observed even in blastocysts obtained from cultures with 5 mM urea. Urea at concentrations 50 mM and higher negatively affected the ability of embryos to reach the blastocyst stage and the highest used concentrations (from 500 mM) caused overall developmental arrest of embryos at the 4- or 5- cell stage. These results show that elevated levels of urea may cause changes in the microenvironment of developing preimplantation embryos, which can negatively affect their quality. Embryo growth remains un-affected up to very high concentrations of urea.

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J. Vadlejch, I. Langrová, M. Borovský, M. Sedmíková, I. Jankovská, J. Fechtner and A. Lytvynets

. Res., 83: 47–51 http://dx.doi.org/10.1007/s004360050206 [11] Healer, J., Ashall, F., Maizels, R. M. (1991): Characterisation of proteolytic enzymes from larval and adult Nippostrongylus brasiliensis. Parasitology, 103: 305–314 http://dx.doi.org/10.1017/S0031182000059588 [12] Jankovská, I., Langrová, I., Vadlejch, J. (2003a): Arrested development of Trichostrongylus colubriformis in experimentally infected rabbits. Effect of acquired resistance, single, multiple doses and size of doses on rise of hypobiosis

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W. Rozek, M. Kwasnik and J.F. Zmudzinski

(2001) Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. Proc Natl Acad Sci U S A 98: 11318-11323. He YA, Xu K, Keiner B, Zhou J, Czudai V, Li T, Chen Z, Liu J, Klenk HD, Shu YL, Sun B (2010) Influenza A Virus replication induces cell cycle arrest in G0/G1 phase. J Virol 84: 12832-12840. Lee SJ, Langhans SA (2012) Anaphase-promoting complex/ cyclosome protein Cdc27 is a target for curcumin- induced cell cycle arrest and apoptosis. BMC Cancer 12:44. Levine B, Sinha

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Radosław Kujawski, Justyna Baraniak, Małgorzata Kania, Joanna Bartkowiak-Wieczorek, Anna Bogacz, Marcin Ożarowski, Michał Cichocki, Ewa Spoz and Przemysław Ł. Mikołajczak

(1):251-280. 43. Gamet-Payrastre L. Signaling pathways and intracellular targets of sulforaphane mediating cell cycle arrest and apoptosis. Curr Cancer Drug Targets 2006; 6:135-145. 44. Clarke JD, Dashwood RH, Ho E. Multi-targeted prevention of cancer by sulforaphane, Cancer Lett 2008; 269:291-304. 45. Singh SV, Srivastava SK, Choi S, Lew KL, Antosiewicz J, Xiao D, Zeng Y, Watkins SC, Johnson CS, Trump DL, Lee YJ, Xiao H, Herman-Antosiewicz A. Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species

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M. Borkovcová, I. Langrová and A. Totková

in den Wildbestanden. Schweiz. Z. Forst., 126: 361–372 [10] Kassai, T. (1999): Veterinary Helminthology. Butterworth-Heinemann, Oxford [11] Kotrlá, B. et al. (1984): Parasitosis of game animals. ČAV, Praha [12] Langrová, I., Makovcová, K., Vadlejch, J., Jankovská, I., Petrtýl, M., Fechtner, J., Keil, P., Lytvynets, A., Borkovcová, M. (2008): Arrested development of sheep strongyles: onset and resumption under field conditions of Central Europe

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Agnieszka Pedrycz, Zbigniew Boratyński, Piotr Siermontowski, Jacek Mendocha, Marcin Orłowski and Katarzyna Van Damme-Ostapowicz

., Halicka H.D., Li C.J., Bhalla K., Bronde E.V., Blagosklonny M.V.: Pharmacological induction of HSp 70 protects apoptosis-prone cells from doxorubicin: comparison with caspase-inhibitor and cycle-arrest-mediated cytoprotection. Cell Death Differ Abstr 2006, 13, 1434-1441. 4. Faubel S., Ljubanovic D., Reznikow L., Somerset H., Dinarello C.A.: Caspase-1-deficient mice are protected against cisplatin- induced apoptosis and acute tubular necrosis. Kidney Int 2004, 66, 2202-2213. 5. Gumucio J.J., Miller D.L.: Functional implications of liver

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J. Cui, Z. Wang and H. Han

[1] Arasu, P., Kwak, D. (1999): Developmental arrest and pregnancy-induced transmammary transmission of Ancylostoma caninum larvae in the murine model. J. Parasitol., 85: 779–784 http://dx.doi.org/10.2307/3285811 [2] Bjorkman, N., Dantzer, V., Leiser, R. (1989): Comparative placenta in laboratory animals. Scand. J. Lab. Anim. Sci., 16: 129–158 [3] Cosoroaba, I., Orjanu, N. (1998): Congenital trichinellosis in the rat. Vet. Parasitol., 77: 147–151 http://dx.doi.org/10.1016/S0304

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D. Lukešová, I. Langrová, J. Vadlejch, I. Jankovská, J. Hlava, P. Válek and Z. Čadková

, B., Černý, V., Kotrlý, A., Minář, J., Ryšavý, B., Šebek, Z. (1984): Parasites of Wild Animals. Prague, Czech Republic, Academia, 191 pp. [17] Kutzer, E., Frey, H. (1976): Die Parasiten der Feldhasen (Lepus europaeus) in Östereich. Berl. Munch. Tierarztl. Wochenschr., 89: 480–483 [18] Langrová, I., Makovcová, K., Vadlejch, J., Jankovská, I., Petrtýl, M., Fechtner, J., Keil, P., Lytvynets, A., Borkovcová, M. (2008): Arrested development of sheep strongyles: onset and resumption under field conditions of Central

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Anna Onopiuk, Andrzej Półtorak and Agnieszka Wierzbicka

–266. 4. Díaz M.T., Vieira C., Pérez C., Lauzurica S., González de Chávarri E., Sánchez M., De la Fuente J.: Effect of lairage time (0 h, 3 h, 6 h or 12 h) on glycogen content and meat quality parameters in suckling lambs. Meat Sci 2014, 96, 653–660. 5. England E.M., Matarneh S.K., Oliver E.M., Apaoblaza A., Scheffler T.L., Gerrard D.E.: Excess glycogen does not resolve high ultimate pH of oxidative muscle. Meat Sci 2015, 114, 95–102. 6. England E.M., Matarneh S.K., Scheffler T.L., Wachet C., Gerrard D.E.: pH inactivation of phosphofructokinase arrests