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Adela Golea, Adriana Rusu, Christiana Dumulesc and Cornelia Bala

References 1. Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, et al. Heart disease and stroke statistics-- 2015 update: a report from the American Heart Association. Circulation. 2015 Jan;131(4):e29-322. DOI: 10.1161/CIR.0000000000000152 2. Muller D, Agrawal R, Arntz HR. How sudden is sudden cardiac death? Circulation. Sep;114(11):1146-50. 3. Nichol G, Thomas E, Callaway CW, Hedges J, Powell JL, Aufderheide TP, et al. Regional variation in out-of-hospital cardiac arrest incidence and outcome

Open access

Victor Raicea, Judit Kovacs, Liviu Moraru and Horatiu Suciu

Abstract

Introduction. Perioperative myocardial injuries are one of the most frequent causes of morbidity and mortality after cardiac surgery, the most common etiology being the poor myocardial protection during aortic crossclamp. During aortic crossclamp progressive accumulation of lactate and intracellular acidosis are well-known phenomena, and are associated with alteration of myocardial contractile function. Our objective was to study the coronary sinus lactate levels as a predictor of postoperative hemodynamic outcome in open-heart surgical patients.

Material and methods. We performed a prospective clinical trial, including 142 adult patients with elective cardiac surgery. Anterograde cardioplegia was administered in 82 patients, retrograde cardioplegia in 60 (in 30 patients it was administrated intermittently and in 30 continuously). Blood was collected simultaneously from the aortic cardioplegic line (inflow) and from coronary sinus or the aortic root (outflow) before aortic crossclamp, after crossclamp at every 10 minutes and after crossclamp removal at 0 and 10 minutes. All patients were operated on cardiopulmonary bypass with cardiac arrest, using warm-blood cardioplegia for cardioprotection.

Results. Lactate levels showed increasing values during aortic crossclamp, and a rapid decline after crossclamp removal. The incidence of low cardiac output was significantly higher in patients with lactate levels that exceeded 4 mmol/L. In patients who died in the postoperative period, lactate level was even higher (5 mmol/L), with only a modest recovery after crossclamp removal.

Conclusion. Monitoring lactate level in coronary sinus blood is a reliable method and has a good prognostic value regarding postoperative morbidity and mortality in open heart surgery

Open access

Yifan Xu, Tianyu Lu, Wu Xu, Yuxiang Dai, Weibang Liang and Wei Jin

, Kang Y, He Y, Liu J, Liang B, Yang P, et al. microRNA-99a acts as a tumor suppressor and is down-regulated in bladder cancer. BMC Urol 2014;14(1):50. DOI: 10.1186/1471-2490-14-50 7. Sun M, Hong S, Li W, Wang P, You J, Zhang X, et al. miR-99a regulates ROS-mediated invasion and migration of lung adenocarcinoma cells by targeting NOX4. Oncol Rep. 2016;35(5):2755-66. DOI: 10.3892/or.2016.4672 8. Hao B, Cui L, Gu Y, Zhang B, Wang M, Zhou H, et al. MiR-99A Suppresses Proliferation, Migration, Invasion and Induces G1-Phase Cell Cycle Arrest

Open access

Didona Ungureanu, Ştefan Mircea Iencean, Cristina Dimitriu, Andrei Ştefan Iencean and Alexandru Tascu

, Oda S, Sadahiro T, Nakamura M, Hirayama Y, Abe R, et al. S-100B and neuron-specific enolase as predictors of neurological outcome in patients after cardiac arrest and return of spontaneous circulation: a systematic review. Crit Care. 2009 Jul;13(4):R121. DOI: 10.1186/cc7973 18. Shaw G, Yang C, Ellis R, Anderson K, Parker Mickle J, Scheff S et al. Hyperphosphory-lated neurofilament NF-H is a serum biomarker of axonal injury. Biochem Biophys Res Commun. 2005 Nov 4;336(4):1268-77. DOI: 10.1016/j.bbrc.2005.08.252 19. Ueno T, Ohori Y, Ito

Open access

Zsombor Mathe, Razvan Constantin Serban, Irina Pintilie, Cristina Somkereki, Adina Hutanu and Alina Scridon

Anaesth. 1993;40(11):1016-21. DOI: 10.1007/BF03009470 20. Wu ZK, Laurikka J, Vikman S, Nieminen R, Moilanen E, Tarkka MR. High postoperative interleukin-8 levels related to atrial fibrillation in patients undergoing coronary artery bypass surgery. World J Surg. 2008;32(12):2643-9. DOI: 10.1007/s00268-008-9758-7 21. Kirklin, JW, Barratt-Boyes, BG. Hypothermia, circulatory arrest, and cardiopulmonary bypass. In: Cardiac surgery. 2nd ed. Churchill Livingstone, New York; 1993: 61-128. 22. Gurbuz O, Kumtepe G, Ercan A, Yolgosteren A, Ozkan H, Karal IH, et

Open access

Mohd. Rashdan Abd. Rahim, Jin Ai Mary Anne Tan, Ravishankar Ram Mani and Umah Rani Kuppusamy

oxidative stress. BMC Complementary and Alternative Medicine 2014;14:392. DOI: 10.1186/1472-6882-14-392 31. de Cássia da Silveira e Sá R, Andrade LN, de Sousa DP. A Review on Anti-Inflammatory Activity of Monoterpenes. Molecules. 2013;18:1227-54. DOI: 10.3390/molecules18011227 32. Puebla-Osorio N, Damiani E, Bover L, Ullrich SE. Platelet-activating factor induces cell cycle arrest and disrupts the DNA damage response in mast cells. Cell Death Dis. 2015 May 7;6:e1745. 33. Fisher G, Alvarez JA, Ellis AC, Granger WM, Ovalle F, Man CD, et al. Race

Open access

Geanina Andreea Ilinoiu, Raluca Tirintica, Cosmin Lungu and Adriana Mihai

. Alzheimers Res Ther. 2013; 5(2):9. DOI: 10.1186/alzrt163. 35. Randall J, Mortberg E, Provuncher GK, Fournier DR, Duffy DC, Rubertsson S, et al. Tau proteins in serum predict neurological outcome after hypoxic brain injury from cardiac arrest: results of a pilot study. Resuscitation. 2013 Mar; 84(3):351-6. DOI: 10.1016/j. resuscitation.2012.07.027. 36. Liliang PC, Liang CL, Weng HC, Lu K, Wang KW, Cheng HJ, et al. Tau proteins in serum predict outcome after severe traumatic brain injury. J Surg Res. 2010 May 15; 160(2):302-7. DOI: 10.1016/j

Open access

Li-Wei Gao and Guo-Liang Wang

;7(51):85235. DOI: 10.18632/oncotarget.13252 33. Huang SH, Xiao-Li MA, Qiu C, Huang JA, Kong WH, Xie JW et al. The overexpression of cyclin B1 and CDK1 in lung carcinoma and its clinical significance. Journal of Shandong University. 2004;39(5):122-4. 34. Jacquot C, Rousseau B, Carbonnelle D, Chinou I, Malleter M, Tomasoni C et al. Cucurbitacin-D-induced CDK1 mRNA up-regulation causes proliferation arrest of a non-small cell lung carcinoma cell line (NSCLC-N6). Anticancer Res. 2014;34(9):4797-806. 35. Cooper WA, Kohonencorish MR, Mccaughan B, Kennedy C