References 1. Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, et al. Heart disease and stroke statistics-- 2015 update: a report from the American Heart Association. Circulation. 2015 Jan;131(4):e29-322. DOI: 10.1161/CIR.0000000000000152 2. Muller D, Agrawal R, Arntz HR. How sudden is sudden cardiac death? Circulation. Sep;114(11):1146-50. 3. Nichol G, Thomas E, Callaway CW, Hedges J, Powell JL, Aufderheide TP, et al. Regional variation in out-of-hospital cardiac arrest incidence and outcome
Adela Golea, Adriana Rusu, Christiana Dumulesc and Cornelia Bala
Victor Raicea, Judit Kovacs, Liviu Moraru and Horatiu Suciu
Introduction. Perioperative myocardial injuries are one of the most frequent causes of morbidity and mortality after cardiac surgery, the most common etiology being the poor myocardial protection during aortic crossclamp. During aortic crossclamp progressive accumulation of lactate and intracellular acidosis are well-known phenomena, and are associated with alteration of myocardial contractile function. Our objective was to study the coronary sinus lactate levels as a predictor of postoperative hemodynamic outcome in open-heart surgical patients.
Material and methods. We performed a prospective clinical trial, including 142 adult patients with elective cardiac surgery. Anterograde cardioplegia was administered in 82 patients, retrograde cardioplegia in 60 (in 30 patients it was administrated intermittently and in 30 continuously). Blood was collected simultaneously from the aortic cardioplegic line (inflow) and from coronary sinus or the aortic root (outflow) before aortic crossclamp, after crossclamp at every 10 minutes and after crossclamp removal at 0 and 10 minutes. All patients were operated on cardiopulmonary bypass with cardiac arrest, using warm-blood cardioplegia for cardioprotection.
Results. Lactate levels showed increasing values during aortic crossclamp, and a rapid decline after crossclamp removal. The incidence of low cardiac output was significantly higher in patients with lactate levels that exceeded 4 mmol/L. In patients who died in the postoperative period, lactate level was even higher (5 mmol/L), with only a modest recovery after crossclamp removal.
Conclusion. Monitoring lactate level in coronary sinus blood is a reliable method and has a good prognostic value regarding postoperative morbidity and mortality in open heart surgery
Yifan Xu, Tianyu Lu, Wu Xu, Yuxiang Dai, Weibang Liang and Wei Jin
, Kang Y, He Y, Liu J, Liang B, Yang P, et al. microRNA-99a acts as a tumor suppressor and is down-regulated in bladder cancer. BMC Urol 2014;14(1):50. DOI: 10.1186/1471-2490-14-50 7. Sun M, Hong S, Li W, Wang P, You J, Zhang X, et al. miR-99a regulates ROS-mediated invasion and migration of lung adenocarcinoma cells by targeting NOX4. Oncol Rep. 2016;35(5):2755-66. DOI: 10.3892/or.2016.4672 8. Hao B, Cui L, Gu Y, Zhang B, Wang M, Zhou H, et al. MiR-99A Suppresses Proliferation, Migration, Invasion and Induces G1-Phase Cell Cycle Arrest
Didona Ungureanu, Ştefan Mircea Iencean, Cristina Dimitriu, Andrei Ştefan Iencean and Alexandru Tascu
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Li-Wei Gao and Guo-Liang Wang
;7(51):85235. DOI: 10.18632/oncotarget.13252 33. Huang SH, Xiao-Li MA, Qiu C, Huang JA, Kong WH, Xie JW et al. The overexpression of cyclin B1 and CDK1 in lung carcinoma and its clinical significance. Journal of Shandong University. 2004;39(5):122-4. 34. Jacquot C, Rousseau B, Carbonnelle D, Chinou I, Malleter M, Tomasoni C et al. Cucurbitacin-D-induced CDK1 mRNA up-regulation causes proliferation arrest of a non-small cell lung carcinoma cell line (NSCLC-N6). Anticancer Res. 2014;34(9):4797-806. 35. Cooper WA, Kohonencorish MR, Mccaughan B, Kennedy C
Mohd. Rashdan Abd. Rahim, Jin Ai Mary Anne Tan, Ravishankar Ram Mani and Umah Rani Kuppusamy
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Geanina Andreea Ilinoiu, Raluca Tirintica, Cosmin Lungu and Adriana Mihai
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Zsombor Mathe, Razvan Constantin Serban, Irina Pintilie, Cristina Somkereki, Adina Hutanu and Alina Scridon
Anaesth. 1993;40(11):1016-21. DOI: 10.1007/BF03009470 20. Wu ZK, Laurikka J, Vikman S, Nieminen R, Moilanen E, Tarkka MR. High postoperative interleukin-8 levels related to atrial fibrillation in patients undergoing coronary artery bypass surgery. World J Surg. 2008;32(12):2643-9. DOI: 10.1007/s00268-008-9758-7 21. Kirklin, JW, Barratt-Boyes, BG. Hypothermia, circulatory arrest, and cardiopulmonary bypass. In: Cardiac surgery. 2nd ed. Churchill Livingstone, New York; 1993: 61-128. 22. Gurbuz O, Kumtepe G, Ercan A, Yolgosteren A, Ozkan H, Karal IH, et
Amina H Hassab, Dalia A Nafea, Rania S Swelem and Basma M Ghazal
1 Introduction Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized by the clonal expansion of myeloid blasts in the peripheral blood, bone marrow, and/or other tissues, with maturation arrest of cells in the bone marrow and impaired production of normal blood cells [ 1 , 2 ]. Treatment strategies of patients with AML are based on various prognostic factors, including age and performance status of the patient, as well as cytogenetic and molecular characteristics of the leukemic clone [ 3 ]. To date, cytogenetic
Mateusz Nowicki, Piotr Stelmach and Anna Szmigielska-Kapłon
colon cancer cells by protein arginine deiminase inhibition causes a p53-dependent cell cycle arrest. PLoS One 2013; 8(1):e53791. doi: 10.1371/journal.pone.0053791. 10.1371/journal.pone.0053791 Cui X Witalison EE Chumanevich AA The induction of microRNA-16 in colon cancer cells by protein arginine deiminase inhibition causes a p53-dependent cell cycle arrest PLoS One 2013 8 1 e53791 10.1371/journal.pone.0053791  Wang W, Corrigan-Cummins M, Barber EA, et al. Aberrant levels of miRNAs in bone marrow microenvironment and peripheral blood of