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Víctor M. Pérez-García, Susan Fitzpatrick, Luis A. Pérez-Romasanta, Milica Pesic, Philippe Schucht, Estanislao Arana and Pilar Sánchez-Gómez

, the so-called field of ‘mathematics of cancer’ requires a substantial medical and biological background. The bottom line is that few mathematicians are willing to do the hard work, also less productive academically, of moving into real mathematical applications to oncology, i.e. so-called mathematical oncology . 2.4 Holism vs. reductionism in mathematical modeling Building good mathematical models of human diseases is a very difficult task, sometimes referred to as an ‘art’ because of its creative nature. There are no rules to construct a good model other