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Erika Matos, Branko Zakotnik and Cvetka Grasic Kuhar

References 1. Schillani G, Era D, Cristante T, Mustacchi G, Richiardi M, Grassi L, et al. 5-HTTLPR polymorphism and anxious preoccupation in early breast cancer patients. Radiol Oncol 2012; 46: 321-7. 2. Sotiriou C, Pusztai L. Gene-expression signatures in breast cancer. N Engl J Med 2009; 360: 790-800. 3. Slamon DJ, Godolphin W, Jones LA, Holt JA, Wong SG, Keith DE, et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 1989; 244: 707-12. 4. Tuzi A, Lombardi D

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Amal Ahmed Mohamed, Eman R. Abd Almonaem, Amira I. Mansour, HebatAllah Fadel Algebaly, Rania Abdelmonem Khattab and Yasmine S. El Abd

Introduction Iron homeostasis is one of the main functions of the liver, being the main place for its storage. The liver controls the iron flow into and around the body via the synthesis of major proteins for iron metabolism such as transferrin and the production of the peptide hepcidin. [ 1 ] Hepcidin, a 25-amino acid peptide present in human serum and urine, is considered the main regulator of iron metabolism through binding to iron carriers, resulting in internalization and lysosomal degradation. [ 2 , 3 ] Inflammation, endoplasmic stress, and iron