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Transcription factors gene expression in chronic rhinosinusitis with and without nasal polyps

Similarly, Th17 were reported to have a potentially protective immune homeostatic role in CRSwNP and to be a part of the normal homeostatic immune response in healthy nasal mucosa by IL-17 production. 15 Regulatory T cells (Treg) control the CRS inflammation; the regulatory cells deficiency or dysfunction can lead to exaggerated inflammation; on the other hand, an elevated Treg number might be a sign of an unsuccessful inflammation control by immune system. 16 Current therapeutic approaches still fail in a portion of patients with severe persistent CRS symptoms and

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Dusp6 inhibits epithelial-mesenchymal transition in endometrial adenocarcinoma via ERK signaling pathway

lines. Both overexpression and knockdown of DUSP6 were constructed to evaluate the functions on regulating the expressions of EMT- markers, cell growth, invasion and migration abilities. The protein levels of ERK and phosphorylated ERK were also analyzed to determine the regulatory role of DUSP6 on the ERK signaling. Our results suggest DUSP6 inhibits EMT process in endometrial adenocarcinoma in vitro via suppressing the ERK signaling pathway. Materials and methods Tissue samples, cell culture Tumor and the corresponding adjacent tumor tissues (more than 5

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Radiological findings of porcine liver after electrochemotherapy with bleomycin

E, Sersa G, Jesenko T, Pelofy S, Teissié, et al. Increased permeability of blood vessels after reversible electroporation is facilitated by alterations in endothelial cell-to-cell junctions. J Control Release 2018; 276: 30-41. doi: 10.1016/j.jconrel.2018.02.032 10.1016/j.jconrel.2018.02.032 29476881 Markelc B Bellard E Sersa G Jesenko T Pelofy S Teissié, et al Increased permeability of blood vessels after reversible electroporation is facilitated by alterations in endothelial cell-to-cell junctions J Control Release 2018 276 30

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Mobilization with cyclophosphamide reduces the number of lymphocyte subpopulations in the leukapheresis product and delays their reconstitution after autologous hematopoietic stem cell transplantation in patients with multiple myeloma

marrow aplasia followed by delayed reconstitution of lymphocytes resulting in partial recovery on collection day. 11 As a consequence lower doses of lymphocytes are col lected and reinfused. There is accumulating evidence that the dose of infused lymphocytes and their recovery on day 15 and 30 after AHSCT are independent prognostic factors for overall survival in patients with non-Hodgkin lymphomas and myeloma. 12 - 15 Among lymphocyte subpopulations the CD16+/56+ natural killer (NK) cells are particularly strong independent predictors of survival. 12 T regulatory

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Inhibition of cathepsin X enzyme influences the immune response of THP-1 cells and dendritic cells infected with Helicobacter pylori

: 559-70. 17. Wang X, Uto T, Sato K, Ide K, Akagi T, Okamoto M, et al. Potent activation of antigen-specific T cells by antigen-loaded nanospheres. Immunol Lett 2005; 98: 123-30. 18. Robinson K, Kenefeck R, Pidgeon EL, Shakib S, Patel S, Polson RJ, et al. Helicobacter pylori -induced peptic ulcer disease is associated with inadequate regulatory T cell responses . Gut 2008; 57: 1375-85. 19. Zhang M, Liu M, Luther J, Kao JY. Helicobacter pylori directs tolerogenic programming of dendritic cells. Gut Microbes

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Effects of electrochemotherapy with cisplatin and peritumoral IL-12 gene electrotransfer on canine mast cell tumors: a histopathologic and immunohistochemical study

. Successful treatment of equine sarcoids with cisplatin electrochemotherapy: a retrospective study of 48 cases Equine Vet J 2012 44 214 20 10.1111/j.2042-3306.2011.00425.x 22 Curiel TJ, Coukos G, Zou L, Alvarez X, Cheng P, Mottram P, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune provolege and predicts reduced survival. Nat Med 2004; 10 : 942-9. 10.1038/nm1093 Curiel TJ Coukos G Zou L Alvarez X Cheng P Mottram P Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune provolege and predicts

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Increased cystatin F levels correlate with decreased cytotoxicity of cytotoxic T cells

Introduction The ability of cancer cells to avoid immune response is one of hallmarks of cancer 1 and thus, several therapeutic approaches are aimed to enhance anticancer immunity. In cancer immunotherapy the activation and maintaining of T cells directed towards tumour antigens provided promising results. 2 In this case the main players are CD8+ cytotoxic T lymphocytes (CTLs), major cell effectors of adaptive immunity, since they possess the ability to kill target cells directly. 3 The key pathway employed by CTLs in target cell killing involves release

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Metformin enhanced in vitro radiosensitivity associates with G2/M cell cycle arrest and elevated adenosine-5’-monophosphate-activated protein kinase levels in glioblastoma

ATP production, induction of cell cycle arrest, autophagy, and apoptotic processes through activation of adenosine-5’-monophosphate-activated protein kinase (AMPK) 5 and inhibition of the mTOR (mammalian target of rapamycin) pathway in glioblastoma cells. 6 , 7 AMPK is a serine/threonine kinase that functions as a cellular energy sensor. AMPK is an obligate heterotrimer, consisting of one catalytic subunit (α) and two regulatory subunits (β and γ). 8 Under cellular stress conditions, AMPK is activated by increased AMP-to-ATP ratios to promote catabolism and

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Imaging of human glioblastoma cells and their interactions with mesenchymal stem cells in the zebrafish (Danio rerio) embryonic brain

regulatory and functional linkages: application to cell proliferation and invasion networks in glioblastoma. J Proteome Res 2015; 14 : 5017-27 10.1021/acs.jproteome.5b00765 Gupta MK Jayaram S Reddy DN Polisetty RV Sirdeshmukh R. Transcriptomic and proteomic data integration and two-dimensional molecular maps with regulatory and functional linkages: application to cell proliferation and invasion networks in glioblastoma J Proteome Res 2015 14 5017 27 4 Klekner Á, Hutóczki G, Virga J, Reményi-Puskár J, Tóth J, Scholtz B, et al. Expression pattern of invasion

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Assessment of differential expression of oncogenes in adenocarcinoma of stomach with fluorescent labeling and simultaneous amplification of gene transcripts

, Ishikawa T, et al. Frequent amplification of the cyclin E gene in human gastric carcinomas. Jpn J Cancer Res 1995; 86(7) : 617-21. Tenderenda M. A study on the prognostic value of cyclins D1 and E expression levels in resectable gastric cancer and on some correlations between cyclins expression, histoclinical parameters and selected protein products of cell-cycle regulatory genes. J Exp Clin Cancer Res 2005; 24(3) : 405-14. Yasui W, Oue N, Aung PP, Matsumura S, Shutoh M, Nakayama H. Molecular

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