Tanja Kosak Soklic, Matija Rijavec, Mira Silar, Ana Koren, Izidor Kern, Irena Hocevar-Boltezar and Peter Korosec
Similarly, Th17 were reported to have a potentially protective immune homeostatic role in CRSwNP and to be a part of the normal homeostatic immune response in healthy nasal mucosa by IL-17 production. 15
RegulatoryTcells (Treg) control the CRS inflammation; the regulatorycells deficiency or dysfunction can lead to exaggerated inflammation; on the other hand, an elevated Treg number might be a sign of an unsuccessful inflammation control by immune system. 16
Current therapeutic approaches still fail in a portion of patients with severe persistent CRS symptoms and
Ming-Jun Fan, Shu-Mei Liang, Peng-Juan He, Xing-Bo Zhao, Ming-Jiang Li and Feng Geng
lines. Both overexpression and knockdown of DUSP6 were constructed to evaluate the functions on regulating the expressions of EMT- markers, cell growth, invasion and migration abilities. The protein levels of ERK and phosphorylated ERK were also analyzed to determine the regulatory role of DUSP6 on the ERK signaling. Our results suggest DUSP6 inhibits EMT process in endometrial adenocarcinoma in vitro via suppressing the ERK signaling pathway.
Materials and methods
Tissue samples, cell culture
Tumor and the corresponding adjacent tumor tissues (more than 5
Maja Brloznik, Nina Boc, Gregor Sersa, Jan Zmuc, Gorana Gasljevic, Alenka Seliskar, Rok Dezman, Ibrahim Edhemovic, Nina Milevoj, Tanja Plavec, Vladimira Erjavec, Darja Pavlin, Masa Bosnjak, Erik Brecelj, Ursa Lampreht Tratar, Bor Kos, Jani Izlakar, Marina Stukelj, Damijan Miklavcic and Maja Cemazar
E, Sersa G, Jesenko T, Pelofy S, Teissié, et al. Increased permeability of blood vessels after reversible electroporation is facilitated by alterations in endothelial cell-to-cell junctions. J Control Release 2018; 276: 30-41. doi: 10.1016/j.jconrel.2018.02.032 10.1016/j.jconrel.2018.02.032 29476881
Markelc B Bellard E Sersa G Jesenko T Pelofy S Teissié, et al Increased permeability of blood vessels after reversible electroporation is facilitated by alterations in endothelial cell-to-cell junctions J Control Release 2018 276 30
Matevz Skerget, Barbara Skopec, Darja Zontar and Peter Cernelc
marrow aplasia followed by delayed reconstitution of lymphocytes resulting in partial recovery on collection day. 11 As a consequence lower doses of lymphocytes are col lected and reinfused. There is accumulating evidence that the dose of infused lymphocytes and their recovery on day 15 and 30 after AHSCT are independent prognostic factors for overall survival in patients with non-Hodgkin lymphomas and myeloma. 12 - 15 Among lymphocyte subpopulations the CD16+/56+ natural killer (NK) cells are particularly strong independent predictors of survival. 12
Miha Skvarc, David Stubljar, Andreja Natasa Kopitar, Samo Jeverica, Bojan Tepes, Janko Kos and Alojz Ihan
17. Wang X, Uto T, Sato K, Ide K, Akagi T, Okamoto M, et al. Potent activation of antigen-specific Tcells by antigen-loaded nanospheres. Immunol Lett 2005; 98: 123-30.
18. Robinson K, Kenefeck R, Pidgeon EL, Shakib S, Patel S, Polson RJ, et al. Helicobacter pylori -induced peptic ulcer disease is associated with inadequate regulatoryTcell responses . Gut 2008; 57: 1375-85.
19. Zhang M, Liu M, Luther J, Kao JY. Helicobacter pylori directs tolerogenic programming of dendritic cells. Gut Microbes
Claudia Salvadori, Tanja Svara, Guido Rocchigiani, Francesca Millanta, Darja Pavlin, Maja Cemazar, Ursa Lampreht Tratar, Gregor Sersa, Natasa Tozon and Alessandro Poli
. Successful treatment of equine sarcoids with cisplatin electrochemotherapy: a retrospective study of 48 cases Equine Vet J 2012 44 214 20 10.1111/j.2042-3306.2011.00425.x
22 Curiel TJ, Coukos G, Zou L, Alvarez X, Cheng P, Mottram P, et al. Specific recruitment of regulatoryTcells in ovarian carcinoma fosters immune provolege and predicts reduced survival. Nat Med 2004; 10 : 942-9. 10.1038/nm1093 Curiel TJ Coukos G Zou L Alvarez X Cheng P Mottram P Specific recruitment of regulatoryTcells in ovarian carcinoma fosters immune provolege and predicts
Mateja Prunk, Milica Perisic Nanut, Jerica Sabotic, Urban Svajger and Janko Kos
The ability of cancer cells to avoid immune response is one of hallmarks of cancer 1 and thus, several therapeutic approaches are aimed to enhance anticancer immunity. In cancer immunotherapy the activation and maintaining of Tcells directed towards tumour antigens provided promising results. 2 In this case the main players are CD8+ cytotoxic T lymphocytes (CTLs), major cell effectors of adaptive immunity, since they possess the ability to kill target cells directly. 3 The key pathway employed by CTLs in target cell killing involves release
Sebastian Adeberg, Denise Bernhardt, Semi B. Harrabi, Nils H. Nicolay, Juliane Hörner-Rieber, Laila König, Michael Repka, Angela Mohr, Amir Abdollahi, Klaus-Josef Weber, Juergen Debus and Stefan Rieken
ATP production, induction of cell cycle arrest, autophagy, and apoptotic processes through activation of adenosine-5’-monophosphate-activated protein kinase (AMPK) 5 and inhibition of the mTOR (mammalian target of rapamycin) pathway in glioblastoma cells. 6 , 7
AMPK is a serine/threonine kinase that functions as a cellular energy sensor. AMPK is an obligate heterotrimer, consisting of one catalytic subunit (α) and two regulatory subunits (β and γ). 8 Under cellular stress conditions, AMPK is activated by increased AMP-to-ATP ratios to promote catabolism and
Milos Vittori, Barbara Breznik, Tajda Gredar, Katja Hrovat, Lilijana Bizjak Mali and Tamara T Lah
regulatory and functional linkages: application to cell proliferation and invasion networks in glioblastoma. J Proteome Res 2015; 14 : 5017-27 10.1021/acs.jproteome.5b00765
Gupta MK Jayaram S Reddy DN Polisetty RV Sirdeshmukh R. Transcriptomic and proteomic data integration and two-dimensional molecular maps with regulatory and functional linkages: application to cell proliferation and invasion networks in glioblastoma J Proteome Res 2015 14 5017 27
4 Klekner Á, Hutóczki G, Virga J, Reményi-Puskár J, Tóth J, Scholtz B, et al. Expression pattern of invasion
Uroš Rajčevic, Petra Hudler, Gordan Mijovski, Gregor Gorjanc, Georg Hoelzl, Stanislav Repše, Robert Juvan, Milena Kovač, Christian Huber and Radovan Komel
, Ishikawa T, et al. Frequent amplification of the cyclin E gene in human gastric carcinomas. Jpn J Cancer Res 1995; 86(7) : 617-21.
Tenderenda M. A study on the prognostic value of cyclins D1 and E expression levels in resectable gastric cancer and on some correlations between cyclins expression, histoclinical parameters and selected protein products of cell-cycle regulatory genes. J Exp Clin Cancer Res 2005; 24(3) : 405-14.
Yasui W, Oue N, Aung PP, Matsumura S, Shutoh M, Nakayama H. Molecular