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Gabriella Schiera, Valentina Contrò, Alessia Sacco, Alessandra Macchiarella, Pawel Cieszczyk and Patrizia Proia

mammalian genome. Science. 2005;309(5740):1559-1563; doi: 10.1126/science.1112014. 22. Engström PG, Suzuki H, Ninomiya N, Akalin A, Sessa L, Lavorgna G, et al. Complex loci in human and mouse genomes. PLoS Genet. 2006;2(4):e47; doi: 10.1371/journal. pgen.0020047. 23. Inagaki S, Numata K, Kondo T, Tomita M, Yasuda K, Kanai A, et al. Identification and expression analysis of putative mRNA-like non-coding RNA in Drosophila. Genes Cells. 2005;10 (12):1163-1173; doi: 10.1111/j.1365-2443.2005.00910.x. 24. Ravasi T, Suzuki H

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Matthias Wilhelm Hoppe, Christian Baumgart, Thomas Hilberg, Jürgen Freiwald and Udo Frank Wehmeier

different blood samples used ( Wehmeier and Hilberg, 2014 ). While we analyzed capillary whole blood, venous blood serum had been examined in a previous study ( Aoi et al., 2013 ). In contrast to blood serum, capillary blood still contains cells, which may contribute to the differences in observed C T values ( Wehmeier and Hilberg, 2014 ). Since all C T values of this study were below the cut-off value of 35 PCR cycles, where circulating miRs are difficult to quantify ( Aoi et al., 2013 ), our results are appropriate and allow further discussions. Our first major

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Krzysztof Krzeminski

nitroprusside: interactions with ANG II and norepinephrine Am J Physiol Regul Integr Comp Physiol 2001 281 R1887 1894 Chini EN, Choi E, Grande JP, Burnett JC, Dousa TP. Adrenomedullin suppresses mitogenesis in rat mesangial cells via cAMP pathway. Biochem Biophys Res Commun , 1995; 215: 868-873 10.1006/bbrc.1995.2544 Chini EN Choi E Grande JP Burnett JC Dousa TP Adrenomedullin suppresses mitogenesis in rat mesangial cells via cAMP pathway Biochem Biophys Res Commun 1995 215 868 873 Cockcroft JR, Noon JP, Gardner-Medwin J, Bennett T. Haemodynamic effects of

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A. Maciejewska-Karłowska, A. Leońska-Duniec, P. Cięszczyk, M. Sawczuk, J. Eider, K. Ficek and S. Sawczyn

:63,269-273. Baar K, Wende AR, Jones TE, Marison M, Nolte LA, Chen M, Kelly DP, Holloszy JO. Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1. FASEB J. 2002:16,1879-1886. Bouchard C, Rankinen T, Chagnon YC, Rice T, Perusse L, Gagnon J, Borecki I, An P, Leon AS, Skinner JS, Wilmore JH, Province M, Rao DC. Genomic scan for maximal oxygen uptake and its response to training in the HERITAGE Family Study. J Appl Physiol. 2000:88,551-559. Druzhevskaya AM, Ahmetov II, Astratenkova IV

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Katarzyna Krych-Garsztka, Hanna Mizgajska-Wiktor and Anna Goździcka-Józefiak

-12-1964. Kajimoto Y., Rotwein P., Structure of the chicken insulin-like growth factor I gene. J Biol Chem , 1991, 266, 9724-9731. McLellan A. S., Kealey T., Landglands K., An E box in the exon 1 promoter regulates insulin-like growth factor-I expression in differentiating. Am J Physiol Cell Physiol , 2006, 291 (2), C300-C307, doi:10.1152/ajpcell.00345.2005. Berry M., Unterman T., The IGF-I system: molecular biology, physiology and clinical applications (book review). Med Sci Sports Exerc , 2000, 32 (2), 547

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Agata Leońska-Duniec, Zbigniew Jastrzębski, Aleksandra Zarębska, Wojciech Smółka and Paweł Cięszczyk

Langenberg C Aadahl M Grarup N Linneberg A Paré G. Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry PLoS Genet 2013 9 7 e1003607 Balthasar N, Dalgaard LT, Lee CE, Yu J, Funahashi H, Williams T, Ferreira M, Tang V, McGovern RA, Kenny CD, Christiansen LM, Edelstein E, Choi B, Boss O, Aschkenasi C, Zhang CY, Mountjoy K, Kishi T, Elmquist JK, Lowell BB. Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell , 2005; 123(3): 493-505 10.1016/j.cell.2005

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Maryam Nourshahi, Fatemeh Alirezaei and Farid Bahrpeyma

menstrual cycle and sport performance. Clin Sports Med. 2005. 24:51-82. Chen XY, Chen L, Wolpaw JR and Jakman LB. Corticospinal tract transaction reduces H-reflex circadian rhythm in rats. Brain research, 2002. 942(1-2): p101-108. Darleen A, Sandoval S, Katheleen S. Gender differences in the endocrine and metabolic responses to hypoxic exercise. Appl Physiol 2002. 92: 504-512. Davis, SN, Galassett P, Wasserman DH, and Tate D. Effects of gender on neuroendocrine and metabolic counter regulatory

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Paweł Cięszczyk, Aleksandra Zarębska, Zbigniew Jastrzębski, Michał Sawczyn, Izabela Kozakiewicz-Drobnik, Agata Leońska-Duniec, Mariusz Kaczmarczyk, Agnieszka Maciejewska-Skrendo, Piotr Żmijewski, Grzegorz Trybek, Wojciech Smółka, Jan Pilch, Katarzyna Leźnicka, Ewelina Lulińska-Kuklik, Marek Sawczuk and Myosotis Massidda

birth defects ( Kluijtmans et al., 1997 ). A second common MTHFR polymorphism is an adenosine to cytosine transversion at nucleotide position 1298 (A1298C, rs1801131) that results in a glutamate to alanine substitution within C-terminal, Sadenosylmethionine (SAM) regulatory domain of the protein ( Weisberg et al., 1998 ). It has been observed that individuals with the 1298 CC genotype have approximately 60 percent specific wild-type in vitro MTHFR activity ( van der Put et al., 1998 ). It suggests that both mutant 677T and 1298C alleles of the MTHFR C677T and A1298C

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Mateusz Radojewski, Tomasz Podgórski, Barbara Pospieszna, Jakub Kryściak, Ewa Śliwicka and Joanna Karolkiewicz

of events, which seem to include muscle rupture due to myofibril injury (rupture of myofibrils), impaired excitation-contraction coupling associated with local ATP depletion, changes in the intracellular calcium homeostasis, oxidative stress and inflammation ( Nikolaidis et al., 2008 ). On the other hand, accumulation of reactive oxygen and nitrogen species (RONS), and cytokines stimulate changes in cell signaling and gene expression, which may contribute to adaptive responses to contractile activity, including changes in stress protein expression and upregulation

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Nurten Dinç, Selda Bereket Yücel, Fatma Taneli and Metin Vehbi Sayın

, and stored in a red top test tube (flat tube) and a purple test tube (EDTA-containing tube). The red test tube that did not contain anticoagulant was used for the analysis of serum total cholesterol, triglyceride, HDL cholesterol, Hcy, folate and vitamin B12. The blood was centrifuged and the serums were separated from the cells to be analyzed. The blood specimen in the purple test tube containing the hemogram EDTA was analyzed on the same day using the blood cell count machine. For the MTHFR C677T mutation and analysis, DNA samples were obtained from the EDTA