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Transcription factors gene expression in chronic rhinosinusitis with and without nasal polyps

Similarly, Th17 were reported to have a potentially protective immune homeostatic role in CRSwNP and to be a part of the normal homeostatic immune response in healthy nasal mucosa by IL-17 production. 15 Regulatory T cells (Treg) control the CRS inflammation; the regulatory cells deficiency or dysfunction can lead to exaggerated inflammation; on the other hand, an elevated Treg number might be a sign of an unsuccessful inflammation control by immune system. 16 Current therapeutic approaches still fail in a portion of patients with severe persistent CRS symptoms and

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LncRNA NEAT1 promotes endometrial cancer cell proliferation, migration and invasion by regulating the miR-144-3p/EZH2 axis

.1016/j.cancergen.2017.06.003 10.1016/j.cancergen.2017.06.003 29025584 Sun W Yang Y Xu C Guo J Regulatory mechanisms of long noncoding RNAs on gene expression in cancers Cancer Genet 2017 216-217 105 10 10.1016/j.cancergen.2017.06.003 6 Jing N, Huang T, Guo H, Yang J, Li M, Chen Z, et al. LncRNA CASC15 promotes colon cancer cell proliferation and metastasis by regulating the miR4310/LGR5/Wnt/betacatenin signaling pathway. Mol Med Rep 2018; 18: 2269-76. doi: 10.3892/mmr.2018.9191 29956772 Jing N Huang T Guo H Yang J Li

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Dusp6 inhibits epithelial-mesenchymal transition in endometrial adenocarcinoma via ERK signaling pathway

lines. Both overexpression and knockdown of DUSP6 were constructed to evaluate the functions on regulating the expressions of EMT- markers, cell growth, invasion and migration abilities. The protein levels of ERK and phosphorylated ERK were also analyzed to determine the regulatory role of DUSP6 on the ERK signaling. Our results suggest DUSP6 inhibits EMT process in endometrial adenocarcinoma in vitro via suppressing the ERK signaling pathway. Materials and methods Tissue samples, cell culture Tumor and the corresponding adjacent tumor tissues (more than 5

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Cytokine CCL5 and receptor CCR5 axis in glioblastoma multiforme

-1 glioma growth Neoplasia 2015 17 776 88 10.1016/j.neo.2015.10.002 72 Chakraborty R, Rooney C, Dotti G, Savoldo B. Changes in chemokine receptor expression of regulatory T cells after ex vivo culture. J Immunother 2012; 35: 329-36. doi: 10.1097/CJI.0b013e318255adcc 22495390 10.1097/CJI.0b013e318255adcc Chakraborty R Rooney C Dotti G Savoldo B Changes in chemokine receptor expression of regulatory T cells after ex vivo culture J Immunother 2012 35 329 36 10.1097/CJI.0b013e318255adcc 73 Wang SW, Liu SC, Sun HL, Huang

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Radiological findings of porcine liver after electrochemotherapy with bleomycin

E, Sersa G, Jesenko T, Pelofy S, Teissié, et al. Increased permeability of blood vessels after reversible electroporation is facilitated by alterations in endothelial cell-to-cell junctions. J Control Release 2018; 276: 30-41. doi: 10.1016/j.jconrel.2018.02.032 29476881 10.1016/j.jconrel.2018.02.032 Markelc B Bellard E Sersa G Jesenko T Pelofy S Teissié, et al Increased permeability of blood vessels after reversible electroporation is facilitated by alterations in endothelial cell-to-cell junctions J Control Release 2018 276 30

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Mobilization with cyclophosphamide reduces the number of lymphocyte subpopulations in the leukapheresis product and delays their reconstitution after autologous hematopoietic stem cell transplantation in patients with multiple myeloma

marrow aplasia followed by delayed reconstitution of lymphocytes resulting in partial recovery on collection day. 11 As a consequence lower doses of lymphocytes are col lected and reinfused. There is accumulating evidence that the dose of infused lymphocytes and their recovery on day 15 and 30 after AHSCT are independent prognostic factors for overall survival in patients with non-Hodgkin lymphomas and myeloma. 12 - 15 Among lymphocyte subpopulations the CD16+/56+ natural killer (NK) cells are particularly strong independent predictors of survival. 12 T regulatory

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Inhibition of cathepsin X enzyme influences the immune response of THP-1 cells and dendritic cells infected with Helicobacter pylori

: 559-70. 17. Wang X, Uto T, Sato K, Ide K, Akagi T, Okamoto M, et al. Potent activation of antigen-specific T cells by antigen-loaded nanospheres. Immunol Lett 2005; 98: 123-30. 18. Robinson K, Kenefeck R, Pidgeon EL, Shakib S, Patel S, Polson RJ, et al. Helicobacter pylori -induced peptic ulcer disease is associated with inadequate regulatory T cell responses . Gut 2008; 57: 1375-85. 19. Zhang M, Liu M, Luther J, Kao JY. Helicobacter pylori directs tolerogenic programming of dendritic cells. Gut Microbes

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Effects of electrochemotherapy with cisplatin and peritumoral IL-12 gene electrotransfer on canine mast cell tumors: a histopathologic and immunohistochemical study

. Successful treatment of equine sarcoids with cisplatin electrochemotherapy: a retrospective study of 48 cases Equine Vet J 2012 44 214 20 10.1111/j.2042-3306.2011.00425.x 22 Curiel TJ, Coukos G, Zou L, Alvarez X, Cheng P, Mottram P, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune provolege and predicts reduced survival. Nat Med 2004; 10 : 942-9. 10.1038/nm1093 Curiel TJ Coukos G Zou L Alvarez X Cheng P Mottram P Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune provolege and predicts

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Increased cystatin F levels correlate with decreased cytotoxicity of cytotoxic T cells

Introduction The ability of cancer cells to avoid immune response is one of hallmarks of cancer 1 and thus, several therapeutic approaches are aimed to enhance anticancer immunity. In cancer immunotherapy the activation and maintaining of T cells directed towards tumour antigens provided promising results. 2 In this case the main players are CD8+ cytotoxic T lymphocytes (CTLs), major cell effectors of adaptive immunity, since they possess the ability to kill target cells directly. 3 The key pathway employed by CTLs in target cell killing involves release

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Metformin enhanced in vitro radiosensitivity associates with G2/M cell cycle arrest and elevated adenosine-5’-monophosphate-activated protein kinase levels in glioblastoma

ATP production, induction of cell cycle arrest, autophagy, and apoptotic processes through activation of adenosine-5’-monophosphate-activated protein kinase (AMPK) 5 and inhibition of the mTOR (mammalian target of rapamycin) pathway in glioblastoma cells. 6 , 7 AMPK is a serine/threonine kinase that functions as a cellular energy sensor. AMPK is an obligate heterotrimer, consisting of one catalytic subunit (α) and two regulatory subunits (β and γ). 8 Under cellular stress conditions, AMPK is activated by increased AMP-to-ATP ratios to promote catabolism and

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