cells expressing IL-2 receptor alpha-chains(CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol, 1995, 155(3): 1151-1164.
8 Li F, Li Y, Wu S, et al . Distribution of Human Papilloma Virus High Risk Subtypes in Patients with Condyloma Acuminatum. Chinese Journal of Nosocomiology , 2012, 22 (1): 210-212.
9 Sun G. Relationship between Human Papillomavirus Infection and RegulatoryT Lymphocyte and Helper TCell 17 in Patients with Condyloma Acuminatum. Chinese Journal of Clinicians (Electronic Edition
of extracellular and intracellular microbial infections and can defend against invasion of Brucella through cooperation with Th1 cells [ 12 ]. The antibody response to Brucella proteins, mediated by interleukin 17 (IL-17) secreted by Th17 cells, plays a key role in brucellosis vaccine [ 13 ]. RegulatoryTcells (Tregs) inhibit the immune function of effector Tcells, promoting Brucella invasion [ 14 ]. Therefore, the occurrence of brucellosis may be related to the imbalance in Treg/Th17 cells. Clapp et al. [ 15 ] have observed from nasal mucosa infection that
inhibitor, CI994, improves nuclear reprogramming and in vitro developmental potential of cloned pig embryos. Cell. Reprogram., 20 (3): 205–213.
Kishigami S., Mizutani E., Ohta H., Hikichi T., Thuan N.V., Wakayama S., Bui H.T., Wakayama T. (2006). Significant improvement of mouse cloning technique by treatment with trichostatin A after somatic nuclear transfer. Biochem. Biophys. Res. Commun., 340 (1): 183–189.
Kumar D., Sarkhel B.C. (2017). Differential expression pattern of key regulatory developmental genes in pre-implant zona free cloned vs in vitro
Patricia Adu-Asiamah, Qiying Leng, Haidong Xu, Jiahui Zheng, Zhihui Zhao, Lilong An and Li Zhang
. Mol. Cell., 56: 55–66.
Bassel-Duby, R., and Olson, E. N. (2006). Signaling pathways in skeletal muscle remodeling. Annu. Rev. Biochem.,75: 19–37.
Chen, L. L., and Yang, L. (2015). Regulation of circRNA biogenesis. RNA Biol.12, 381–388
Du, W. W., Yang, W., Liu, E., Yang, Z., Dhaliwal, P., and Yang, B. B. (2016). Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2. Nucleic Acids Res., 44: 2846–2858.
Ivanov, A., Memczak, S., Wyler, E., Torti, F., Porath, H. T., Orejuela, M. R., Piechotta, M., Levanon
Asiamah Amponsah Collins, Kun Zou, Zhang Li and Su Ying
Accili D., Arden K.C. (2004). FoxOs at the crossroads of cellular review metabolism, differentiation, and transformation. Cell, 117: 421–426.
Andreote A.P.D., Rosario M.F., Ledur M.C., Jorge E.C., Sonstegard T.S., Matukumalli L., Coutinho L.L. (2014). Identification and characterization of microRNAs expressed in chicken skeletal muscle. Genet. Mol. Res., 13: 1465–1479; https://doi.org/10.4238/2014.March.6.5 .
Baquero-Perez B., Kuchipudi S.V., Nelli R.K., Chang K.C. (2012). A simplified but robust method for the isolation of avian and
Martín R. Langa S. Reviriego C. Jiménez E. Olivares M. Boza J. Jiménez J. Fernández L. Xaus J. Rodríguez M. The commensal microflora of human milk: new perpectives for food bacteriotherapy and probiotics Trends Food Sci Technol 2004 15 121 127
11 Maeda Y., Ohtsuka H., Tomioka M., Oikawa M.: Effect of progesterone on Th1/Th2/Th17 and RegulatoryTcell-related genes in peripheral blood mononuclear cells during pregnancy in cows. Vet Res Commun 2012, 37, 43–49.
Maeda Y. Ohtsuka H
cell population. This phenomenon causes an imbalance of Th1/Th2, reduction of antiviral substance secreted by Th1, and attenuation of anti-HBV-specific T lymphocyte immune response, which cause chronic HBV infection. IL-35 is an immunosuppressive cytokine secreted by regulatoryT lymphocytes. In vitro experiments have shown that IL-35 can also inhibit the proliferation of HBV-specific CTLs, weaken the immune responses of anti-HBV cells, and play an important role in the formation of immune tolerance in HBV infection [ 21 ]. Therefore, IL-35 is considered to be
Yan-hui Chen, Heng-hui Zhang, Yan Wang, Xing-wang Xie, Ran Fei, Xue-yan Wang, Lai Wei and Hong-song Chen
1. Hori S, Nomura T, Sakaguchi S. Control of regulatoryTcell development by the transcription factor Foxp3. Science 2003;299:1057-1061.
2. Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatoryTcells. Nat Immunol 2003;4:330-336.
3. Zheng Y, Rudensky AY. Foxp3 in control of the regulatoryTcell lineage. Nat Immunol 2007;8:457-462.
4. Williams LM, Rudensky AY. Maintenance of the Foxp3-dependent developmental program in mature
resulting data sets were explored, and influenza viruses containing titin peptide matches were manually identified and annotated.
In addition, reference proteomes of influenza A virus, H3N2 subtype (tax ID: 385580), influenza B virus (tax ID: 518987), and influenza C virus (tax ID: 11553) were used to investigate peptide matching at the 5-mer level.
Immunological potential of shared peptides was analyzed using the Immune Epitope Database (IEDB; www.iedb.org ) resource [ 38 ]. IEDB offers experimental data characterizing antibody and Tcell epitopes studied in human
Tetrodotoxin (TTX) is a strong marine neurotoxin acting by blocking sodium channels of the neuron cell membrane. This toxin is a water-soluble heterocyclic guanidine compound, which is stable in neutral and weak acidic solutions and cannot be inactivated by heat treatment ( 3 , 15 , 24 ). TTX was isolated for the first time in 1909 by the Japanese researcher Yoshizumi Tahara from ovaries of globefish ( 5 , 15 ). Thirty naturally occurring analogues of tetrodotoxin have been detected and many of them have also been shown to have toxic potential