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Investigation of Murine T-Cells and Cancer Cells under Thermal Stressors and 2D Slow Rotating System Effects as a Testbed for Suborbital Flights

reduction of key gene expression in early T-cell activation. American Journal of Physiology—Regulatory, Integrative and Comparative Physiology 308(6): R480-R488 10.1152/ajpregu.00449.2014 Martinez EM Yoshida MC Candelario TLT Fulford MH 2015 Spaceflight and simulated microgravity cause a significant reduction of key gene expression in early T-cell activation American Journal of Physiology—Regulatory, Integrative and Comparative Physiology 308 6 R480 R488 Mehri R, Mavriplis C, Fenech M (2018) Red blood cell aggregates and their effect on non

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In Vitro Toxicological Evaluation of Cigarette Smoke Particulate Matter: Effect of Dimethyl Sulfoxide (DMSO) as Solvent

., J. Matheson, R. P. Fannin Montuschi, L. Flood, and M. I. Luster: Cytokine expression in hepatocytes: Role of oxidant stress; J. Interferon Cytokine Res. 18 (1998) 629-638. 9. Loitsch, S. M., CV. Mallinckrodt, S. Kippengerger, D. Steinhilber, T. O. F. Wagner, and J. Bargon: Reactive oxygen intermediates are involved in IL-8 production induced by hyperosmotic stress in human bronchial epithelial cells; Biochem. Biophys. Res. Commun. 276 (2000) 571-578. 10. Diaz, D., A. Scott, P. Carmichael, W. Shi, and C. Costales

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Changes in the Cellular Concentrations of Elements in Tobacco Leaf Tissues during Growth and Senescence

-80. 4. Leigh, R. A., M. Chater, R. Storey and A. E. Johnstone: Accumulation and sub-cellular distribution of cations in relation to the growth of K + deficient barley; Plant, Cell and Environ. 9 (1986) 595—604. 5. Echlin, P., and S. E. Taylor: The preparation and X-ray microanalysis of bulk frozen hydrated vacu- olate plant tissue; J. Microsc. (Oxf.) 141 (1986) 329—348. 6. Pawley, J. B., and J. T. Norton: A chamber attached to the SEM for fracturing and coating frozen biological specimens; J. Microsc. (Oxf.) 112

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Mainstream Smoke Chemistry and in Vitro and In Vivo Toxicity of the Reference Cigarettes 3R4F and 2R4F

. Richter: Agents associated with lung inflammation induce similar responses in NCI-H292 lung epithelial cells; Toxicol. in vitro 22 (2008) 1782-1728. 14. Carter, CA. and J.T. Hamm: Multiplexed quantitative high content screening reveals that cigarette smoke condensate induces changes in cell structure and function through alterations in cell signaling pathways in human bronchial cells; Toxicology 261 (2009) 89-102. 15. Higuchi, M.A., J. Sagartz, W.K. Shreve, and P.H. Ayres: Comparative subchronic inhalation study of

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The Biological Degradation of Nicotine by Nicotinophilic Microorganisms

References 1. Barz, W., Kettner, M. and W. Hiisemann: On the degradation of nicotine in Nicotiana cell suspension cultures; Planta medica 34 (1978) 73-78. 2. Bernauer, H., Mauch, L. and R. Brandsch: Interaction of the regulatory protein Nic R 1 with the promoter region of the pAOl-encoded 6-hydroxy-D-nicotine oxidase gene of Artbrobacter oxidant; Molecular Microbiology 6 (1992) 1809 -1820. 3. Brandsch, R. and V. Bichler: Riboflavin-dependent expression of flavoenzymes of the

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Cigarette Mainstream Smoke: The Evolution of Methods and Devices for Generation, Exposure and Collection

. Scherer: A Method for In Vitro Analysis of the Biological Activity of Complex Mixtures Such as Sidestream Cigarette Smoke; Exp. Toxic. Pathol. 53 (2001) 141–152. 383. Wolz, L., G. Krause, G. Scherer, M. Aufderheide, and U. Mohr: In Vitro Genotoxic Assay of Sidestream Smoke Using a Human Bronchial Epithelial Cell Line; Food Chem. Toxicol. 40 (2002) 845–850. 384. Bair, W.J., N.S. Porter, D.P. Brown, and A.P. Wehner: Apparatus for Direct Inhalation of Cigarette Smoke by Dogs; J. Appl. Physiol. 26 (1969) 847–850. 385. Cross, F.T., R.F. Palmer, R.E. Filipy

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Influence of Additives on Cigarette Related Health Risks

, K., G. Papatheodorou, K. Ganas, K. Psathakis, P. Panagou, and S. Loukides: pH in Expired Breath Condensate of Patients with Inflammatory Airway Diseases; Am. J. Respir. Crit. Care Med. 165 (2002) 1364–1370. 135. Hunt, J.F., E. Erwin, L. Palmer, J. Vaughan, N. Malhotra, T.A.E. Platts-Mills, and B. Gaston: Ex-pression and Activity of the pH-Regulatory Gluta-minase in the Human Airway Epithelium; Am. J. Respir. Crit. Care Med. 165 (2002) 101–107. 136. Reininghaus, W.: Bioavailability of Nicotine; INBIFO

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Applied mathematics and nonlinear sciences in the war on cancer

, falsification of underlying biological hypotheses and quantitative description of relationships between different components of a system. Mathematical models are limited because they cannot replace experimental results obtained by other biomedical models such as cell lines, research animals or clinical trials. Their advantage over experimentation is in providing a broader picture that may help novel findings and even solutions for some cancer-related problems. Moreover, they could improve clinical care of patients by increasing the use of tools from applied mathematics and

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