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marrow aplasia followed by delayed reconstitution of lymphocytes resulting in partial recovery on collection day. 11 As a consequence lower doses of lymphocytes are col lected and reinfused. There is accumulating evidence that the dose of infused lymphocytes and their recovery on day 15 and 30 after AHSCT are independent prognostic factors for overall survival in patients with non-Hodgkin lymphomas and myeloma. 12 - 15 Among lymphocyte subpopulations the CD16+/56+ natural killer (NK) cells are particularly strong independent predictors of survival. 12
Tanja Kosak Soklic, Matija Rijavec, Mira Silar, Ana Koren, Izidor Kern, Irena Hocevar-Boltezar and Peter Korosec
Similarly, Th17 were reported to have a potentially protective immune homeostatic role in CRSwNP and to be a part of the normal homeostatic immune response in healthy nasal mucosa by IL-17 production. 15
RegulatoryTcells (Treg) control the CRS inflammation; the regulatorycells deficiency or dysfunction can lead to exaggerated inflammation; on the other hand, an elevated Treg number might be a sign of an unsuccessful inflammation control by immune system. 16
Current therapeutic approaches still fail in a portion of patients with severe persistent CRS symptoms and
Ming-Jun Fan, Shu-Mei Liang, Peng-Juan He, Xing-Bo Zhao, Ming-Jiang Li and Feng Geng
lines. Both overexpression and knockdown of DUSP6 were constructed to evaluate the functions on regulating the expressions of EMT- markers, cell growth, invasion and migration abilities. The protein levels of ERK and phosphorylated ERK were also analyzed to determine the regulatory role of DUSP6 on the ERK signaling. Our results suggest DUSP6 inhibits EMT process in endometrial adenocarcinoma in vitro via suppressing the ERK signaling pathway.
Materials and methods
Tissue samples, cell culture
Tumor and the corresponding adjacent tumor tissues (more than 5
Maja Brloznik, Nina Boc, Gregor Sersa, Jan Zmuc, Gorana Gasljevic, Alenka Seliskar, Rok Dezman, Ibrahim Edhemovic, Nina Milevoj, Tanja Plavec, Vladimira Erjavec, Darja Pavlin, Masa Bosnjak, Erik Brecelj, Ursa Lampreht Tratar, Bor Kos, Jani Izlakar, Marina Stukelj, Damijan Miklavcic and Maja Cemazar
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processed. Using dendritic cells, it is possible to present antigens in a way that stimulates Tregulatorycells, which would opposean antitumor response. APCs require a maturation signal in order to promote immunity. Partial maturation may be induced through toll-like receptor signaling from necrotic tumor cells.
The successful use of checkpoint inhibitors led to a breakthrough in the development of cancer immunotherapy. The anti-CTLA-4 monoclonal antibody Ipilimumab was the first checkpoint inhibitor that achieved durable objective responses in metastatic melanoma
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Amadi-Obi A, Yu CR, Liu X, et al. TH17 Cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1
Oliver Dimitrovski, Vancho Spirov, Blagoja Dastevski and Filip Koneski
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