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Nattiya Hirankarn, Krongkamol Hemwijit, Thitima Benjachat and Yingyos Avihingsanon

References 1. Tsao BP. Update on human systemic lupus erythematosus genetics. Curr Opin Rheumatol. 2004; 16:513-21. 2. Zhang H, Yang P, Zhou H, Meng Q, Huang X: Involvement of Foxp3-expressing CD4+ CD25+ regulatory T cells in the development of tolerance induced by transforming growth factor-beta2-treated antigen-presenting cells. Immunology. 2008; 124: 304-14. 3. Namba K, Kitaichi N, Nishida T, Taylor AW. Induction of regulatory T cells by the immunomodulating cytokines alpha-melanocyte-stimulating hormone and

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Supreecha Chattong, Ruttachuk Rungsiwiwut, Wittaya Yindeedej, Amornpun Sereemaspun, Kamthorn Pruksananonda, Pramuan Virutamasen, Anant Setpakdee and Krissanapong Manotham

SC, Stewart MH, Menendez P, George D, Vijayaragavan K, Werbowetski-Ogilvie T, et al. IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro. Nature. 2007; 448:1015-21. 22. Lei T, Jacob S, Ajil-Zaraa I, Dubuisson JB, Irion O, Jaconi M, Feki A. Xeno-free derivation and culture of human embryonic stem cells: current status, problems and challenges. Cell Res. 2007; 17:682-8. 23. Swistowski A, Peng J, Han Y, Swistowska AM, Rao MS, Zeng X. Xeno-free defined conditions for culture of human

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Gong Subo, Li Keng, Jiang Xiaowei, Zhang Mingyu, Ma Libing, Zhang Li and Xiang Xudong

References 1. Calderwood SK, Mambula SS, Gray PJ Jr. Extracellular heat shock proteins in cell signaling and immunity. Ann NY Acad Sci. 2007; 1113:28-39. 2. V, Hauet-Broere F, Berlo S, Paul L, van der Zee R, de Kleer I,et al. Stress proteins as inducers and targets of regulatory T cells in arthritis. Int Rev Immunol. 2005; 24:181-97. 3. Pockley AG, Muthana M, Calderwood SK. The dual immunoregulatory roles of stress proteins. Trends Biochem Sci. 2008; 33:71-9. 4. Gupta RS, Ramachandra NB, Bowes T

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Chotika Suyarnsestakorn, Thatchawan Thanasupawat, Kantima Leelahavanichkul, J. Silvio Gutkind and Apiwat Mutirangura

importin beta superfamily. Biochem Biophys Res Commun. 2003; 303:908-13. 5. Lad C, Williams NH, Wolfenden R. The rate of hydrolysis of phosphomonoester dianions and the exceptional catalytic proficiencies of protein and inositol phosphatases. Proc Natl Acad Sci USA. 2003; 100:5607-10. 6. Virshup DM. Protein phosphatase 2A: a panoply of enzymes. Curr Opin Cell Biol. 2000; 12:180-5. 7. Eichhorn PJ, Creyghton MP, Bernards R. Protein phosphatase 2A regulatory subunits and cancer. Biochim Biophys Acta. 2009; 1795

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Paramee Thongsuksai, Kowit Pruegsanusak and Pleumjit Boonyaphiphat

. Regulators of cell death. Trends Genet. 1995; 11:101-5. 5. Hall PA, Meek D, Lane DP. p53-integrating the complexity. J Pathol. 1996; 180:1-5. 6. Miyashita T, Krajewski S, Krajewska M, Wang HG, Lin HK, Liebermann DA, et al. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene. 1994; 9:1799-805. 7. Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/CDK4. Nature. 1993; 366:704-7. 8. Mork J, Lie AK

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Yongling Ning, Keqing Qian and Chunjian Qi

References 1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ. Cancer statistics, 2008. CA Cancer J Clin. 2008; 58: 71-96. 2. Mizukami Y, Kono K, Kawaguchi Y, Akaike H, Kamimura K, Sugai H, Fujii H. CCL17 and CCL22 chemokines within tumor microenvironment are related to accumulation of Foxp3+ regulatory T cells in gastric cancer. Int J Cancer. 2008; 122:2286-93. 3. Panani AD. Cytogenetic and molecular aspects of gastric cancer: clinical implications. Cancer Lett. 2008; 266:99-115. 4

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Hamid Yaghooti, Mohsen Firoozrai, Soudabeh Fallah and Mohammad Reza Khorramizadeh

in vascular smooth muscle cells. Regulatory Peptides. 2008; 147: 37-44. 11. Higuchi S, Ohtsu H, Suzuki H, Shirai H, Frank GD, Eguchi S. Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology. Clinical Science. 2007; 112:417-28. 12. Das UN. Is angiotensin-II an endogenous proinflammatory molecule? Med Sci Monit. 2005; 11: RA155-162. 13. Mogi M, Iwai M, Horiuchi M. Emerging concepts of regulation of angiotensin II receptors, new players and targets for traditional

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Ying Luo, Yan Lin and Xiao Han

References 1. Kitamura T, Nakae J, Kitamura Y, Kido Y, Biggs WH 3rd, Wright CV, et al. The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest. 2002; 110: 1839-47. 2. Sussel L, Kalamaras J, Hartigan OCDJ, Meneses JJ, Pedersen RA, Rubenstein JL, et al. Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development. 1998; 125:2213-21. 3. Sander M, Sussel L, Conners

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Liuping Zhang, Genbao Shao and Yaoqian Pan

impact Leydig cell differentiation. Biol Reprod. 2010; 83: 488-501. 11. Cherradi N, Rossier MF, Vallotton MB, Timberg R, Friedberg I, Orly J, et al. Submitochondrial distribution of three key steroidogenic proteins (steroidogenic acute regulatory protein and cytochrome P450scc and 3β-hydroxysteroid dehydrogenase isomerase enzymes) upon stimulation by intracellular calcium in adrenal glomerulosa cells. J Biol Chem. 1997; 272: 7899-907. 12. Stocco DM. Recent advances in the role of StAR. Rev Reprod. 1998; 3:82-5. 13. Walsh

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Apitsada Khlongkhlaeo, Richard L. Carter, Rangsun Parnpai and Anthony W.S. Chan

essential regulatory role in maintaining an undifferentiated state, proliferation, and suppresses astrocyte differentiation [ 16 , 47 ]. TLX expression knockout dramatically reduced the neural stem cell population, but increased GFAP staining and extended GFAP processes in the subventricular zone [ 3 ]. This finding suggested that NPCs derived by feeder-free methods may have a higher tendency toward an astrocytic lineage with lower expression of TLX and high expression of GFAP Both methods of NPC derivation can produce NPCs with similar characteristics including the