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Advances in the Study on the Relationship between Regulatory T cells and Human Papilloma Viral Infection

cells expressing IL-2 receptor alpha-chains(CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol, 1995, 155(3): 1151-1164. 8 Li F, Li Y, Wu S, et al . Distribution of Human Papilloma Virus High Risk Subtypes in Patients with Condyloma Acuminatum. Chinese Journal of Nosocomiology , 2012, 22 (1): 210-212. 9 Sun G. Relationship between Human Papillomavirus Infection and Regulatory T Lymphocyte and Helper T Cell 17 in Patients with Condyloma Acuminatum. Chinese Journal of Clinicians (Electronic Edition

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Research progress on the role of immune cells in Brucella infection

of extracellular and intracellular microbial infections and can defend against invasion of Brucella through cooperation with Th1 cells [ 12 ]. The antibody response to Brucella proteins, mediated by interleukin 17 (IL-17) secreted by Th17 cells, plays a key role in brucellosis vaccine [ 13 ]. Regulatory T cells (Tregs) inhibit the immune function of effector T cells, promoting Brucella invasion [ 14 ]. Therefore, the occurrence of brucellosis may be related to the imbalance in Treg/Th17 cells. Clapp et al. [ 15 ] have observed from nasal mucosa infection that

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Relationship between mRNA of immune factors expressed by milk somatic cells and bacteria present in healthy lactating Holstein cows

.1016/j.tifs.2003.09.010 Martín R. Langa S. Reviriego C. Jiménez E. Olivares M. Boza J. Jiménez J. Fernández L. Xaus J. Rodríguez M. The commensal microflora of human milk: new perpectives for food bacteriotherapy and probiotics Trends Food Sci Technol 2004 15 121 127 11 Maeda Y., Ohtsuka H., Tomioka M., Oikawa M.: Effect of progesterone on Th1/Th2/Th17 and Regulatory T cell-related genes in peripheral blood mononuclear cells during pregnancy in cows. Vet Res Commun 2012, 37, 43–49. Maeda Y. Ohtsuka H

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Progress of research on the immune tolerance of chronic HBV infection

cell population. This phenomenon causes an imbalance of Th1/Th2, reduction of antiviral substance secreted by Th1, and attenuation of anti-HBV-specific T lymphocyte immune response, which cause chronic HBV infection. IL-35 is an immunosuppressive cytokine secreted by regulatory T lymphocytes. In vitro experiments have shown that IL-35 can also inhibit the proliferation of HBV-specific CTLs, weaken the immune responses of anti-HBV cells, and play an important role in the formation of immune tolerance in HBV infection [ 21 ]. Therefore, IL-35 is considered to be

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Influenza and sudden unexpected death: the possible role of peptide cross-reactivity

resulting data sets were explored, and influenza viruses containing titin peptide matches were manually identified and annotated. In addition, reference proteomes of influenza A virus, H3N2 subtype (tax ID: 385580), influenza B virus (tax ID: 518987), and influenza C virus (tax ID: 11553) were used to investigate peptide matching at the 5-mer level. Immunological potential of shared peptides was analyzed using the Immune Epitope Database (IEDB; ) resource [ 38 ]. IEDB offers experimental data characterizing antibody and T cell epitopes studied in human

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Marine tetrodotoxin as a risk for human health – a review

Introduction Tetrodotoxin (TTX) is a strong marine neurotoxin acting by blocking sodium channels of the neuron cell membrane. This toxin is a water-soluble heterocyclic guanidine compound, which is stable in neutral and weak acidic solutions and cannot be inactivated by heat treatment ( 3 , 15 , 24 ). TTX was isolated for the first time in 1909 by the Japanese researcher Yoshizumi Tahara from ovaries of globefish ( 5 , 15 ). Thirty naturally occurring analogues of tetrodotoxin have been detected and many of them have also been shown to have toxic potential

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Rai stage-related changes within T/NK cell populations from B-CLL patients

. Expansion of CMV-specific CD8+CD45RA+CD27- T cells in B-cell chronic lymphocytic leukemia. Blood. 2003;102(3):1057-63. 10. Nunes C, Wong R, Mason M, Fegan C, Man S, Pepper C. Expansion of a CD8(+)PD-1(+) replicative senescence phenotype in early stage CLL patients is associated with inverted CD4:CD8 ratios and disease progression. Clin Cancer Res. 2012;18(3):678-87. 11. Giannopoulos K, M Schmitt PW, lstrok. The high frequency of T regulatory cells in patients with B-cell chronic lymphocytic leukemia is diminished through treatment with

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Association of FOXP3 Gene Polymorphism with Chronic Hepatitis B in Chinese Population

References 1. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003;299:1057-1061. 2. Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003;4:330-336. 3. Zheng Y, Rudensky AY. Foxp3 in control of the regulatory T cell lineage. Nat Immunol 2007;8:457-462. 4. Williams LM, Rudensky AY. Maintenance of the Foxp3-dependent developmental program in mature

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Specific Associations Between Clinical Signs, Immune Cells, Disease Genetic Background and Burden in a Group of Patients with B-Cell Chronic Lymphocytic Leukemia

Pathol. 2013 Feb;26(2):182-94. 11. Han T, Abdel-Motal UM, Chang D-K, Sui J, Muvaffak A, Campbell J, et al. Human anti-CCR4 minibody gene transfer for the treatment of cutaneous t-cell lymphoma. PloS one. 2012;7(9):e44455. DOI: 10.1371/journal. pone.0044455 12. Chang D-K, Sui J, Geng S, Muvaffak A, Bai M, Fuhlbrigge RC, et al. Humanization of an anti-CCR4 antibody that kills cutaneous T-cell lymphoma cells and abrogates suppression by T-regulatory cells. Molecular Cancer Therapeutics. 2012;11(11):2451-61. DOI: 10.1158/1535-7163.MCT-12

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Research Progress on Effects of Regulatory B Cells in Infection Immunity

References 1 Koichi Yanaba, Jean-David Bouaziz, et al . A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. Immun, 2008, 28(5):639-50. 2 Mizoguchi A, Bhan AK. A case for regulator y B cells. J Immun, 2006,176(2):705-10. 3 Yang M, Rui K, Wang SG, et al . Regulatory B cells in autoimmune diseases. Cell Mol Immun, 2013, 10(13):122-32 4 Wolf SD, Dittel BN, Hardardottir F, et al . Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice. J Exp Med

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