Search Results

1 - 10 of 75 items :

  • T regulatory cell x
  • Microbiology and Virology x
Clear All
Advances in the Study on the Relationship between Regulatory T cells and Human Papilloma Viral Infection

cells expressing IL-2 receptor alpha-chains(CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol, 1995, 155(3): 1151-1164. 8 Li F, Li Y, Wu S, et al . Distribution of Human Papilloma Virus High Risk Subtypes in Patients with Condyloma Acuminatum. Chinese Journal of Nosocomiology , 2012, 22 (1): 210-212. 9 Sun G. Relationship between Human Papillomavirus Infection and Regulatory T Lymphocyte and Helper T Cell 17 in Patients with Condyloma Acuminatum. Chinese Journal of Clinicians (Electronic Edition

Open access
Research progress on the role of immune cells in Brucella infection

of extracellular and intracellular microbial infections and can defend against invasion of Brucella through cooperation with Th1 cells [ 12 ]. The antibody response to Brucella proteins, mediated by interleukin 17 (IL-17) secreted by Th17 cells, plays a key role in brucellosis vaccine [ 13 ]. Regulatory T cells (Tregs) inhibit the immune function of effector T cells, promoting Brucella invasion [ 14 ]. Therefore, the occurrence of brucellosis may be related to the imbalance in Treg/Th17 cells. Clapp et al. [ 15 ] have observed from nasal mucosa infection that

Open access
Relationship between mRNA of immune factors expressed by milk somatic cells and bacteria present in healthy lactating Holstein cows

.1016/j.tifs.2003.09.010 Martín R. Langa S. Reviriego C. Jiménez E. Olivares M. Boza J. Jiménez J. Fernández L. Xaus J. Rodríguez M. The commensal microflora of human milk: new perpectives for food bacteriotherapy and probiotics Trends Food Sci Technol 2004 15 121 127 11 Maeda Y., Ohtsuka H., Tomioka M., Oikawa M.: Effect of progesterone on Th1/Th2/Th17 and Regulatory T cell-related genes in peripheral blood mononuclear cells during pregnancy in cows. Vet Res Commun 2012, 37, 43–49. Maeda Y. Ohtsuka H

Open access
Progress of research on the immune tolerance of chronic HBV infection

cell population. This phenomenon causes an imbalance of Th1/Th2, reduction of antiviral substance secreted by Th1, and attenuation of anti-HBV-specific T lymphocyte immune response, which cause chronic HBV infection. IL-35 is an immunosuppressive cytokine secreted by regulatory T lymphocytes. In vitro experiments have shown that IL-35 can also inhibit the proliferation of HBV-specific CTLs, weaken the immune responses of anti-HBV cells, and play an important role in the formation of immune tolerance in HBV infection [ 21 ]. Therefore, IL-35 is considered to be

Open access
Influenza and sudden unexpected death: the possible role of peptide cross-reactivity

resulting data sets were explored, and influenza viruses containing titin peptide matches were manually identified and annotated. In addition, reference proteomes of influenza A virus, H3N2 subtype (tax ID: 385580), influenza B virus (tax ID: 518987), and influenza C virus (tax ID: 11553) were used to investigate peptide matching at the 5-mer level. Immunological potential of shared peptides was analyzed using the Immune Epitope Database (IEDB; www.iedb.org ) resource [ 38 ]. IEDB offers experimental data characterizing antibody and T cell epitopes studied in human

Open access
Marine tetrodotoxin as a risk for human health – a review

Introduction Tetrodotoxin (TTX) is a strong marine neurotoxin acting by blocking sodium channels of the neuron cell membrane. This toxin is a water-soluble heterocyclic guanidine compound, which is stable in neutral and weak acidic solutions and cannot be inactivated by heat treatment ( 3 , 15 , 24 ). TTX was isolated for the first time in 1909 by the Japanese researcher Yoshizumi Tahara from ovaries of globefish ( 5 , 15 ). Thirty naturally occurring analogues of tetrodotoxin have been detected and many of them have also been shown to have toxic potential

Open access
Rai stage-related changes within T/NK cell populations from B-CLL patients

. Expansion of CMV-specific CD8+CD45RA+CD27- T cells in B-cell chronic lymphocytic leukemia. Blood. 2003;102(3):1057-63. 10. Nunes C, Wong R, Mason M, Fegan C, Man S, Pepper C. Expansion of a CD8(+)PD-1(+) replicative senescence phenotype in early stage CLL patients is associated with inverted CD4:CD8 ratios and disease progression. Clin Cancer Res. 2012;18(3):678-87. 11. Giannopoulos K, M Schmitt PW, lstrok. The high frequency of T regulatory cells in patients with B-cell chronic lymphocytic leukemia is diminished through treatment with

Open access
Association of FOXP3 Gene Polymorphism with Chronic Hepatitis B in Chinese Population

References 1. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003;299:1057-1061. 2. Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003;4:330-336. 3. Zheng Y, Rudensky AY. Foxp3 in control of the regulatory T cell lineage. Nat Immunol 2007;8:457-462. 4. Williams LM, Rudensky AY. Maintenance of the Foxp3-dependent developmental program in mature

Open access
Specific Associations Between Clinical Signs, Immune Cells, Disease Genetic Background and Burden in a Group of Patients with B-Cell Chronic Lymphocytic Leukemia

Pathol. 2013 Feb;26(2):182-94. 11. Han T, Abdel-Motal UM, Chang D-K, Sui J, Muvaffak A, Campbell J, et al. Human anti-CCR4 minibody gene transfer for the treatment of cutaneous t-cell lymphoma. PloS one. 2012;7(9):e44455. DOI: 10.1371/journal. pone.0044455 12. Chang D-K, Sui J, Geng S, Muvaffak A, Bai M, Fuhlbrigge RC, et al. Humanization of an anti-CCR4 antibody that kills cutaneous T-cell lymphoma cells and abrogates suppression by T-regulatory cells. Molecular Cancer Therapeutics. 2012;11(11):2451-61. DOI: 10.1158/1535-7163.MCT-12

Open access
Research Progress on Effects of Regulatory B Cells in Infection Immunity

References 1 Koichi Yanaba, Jean-David Bouaziz, et al . A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. Immun, 2008, 28(5):639-50. 2 Mizoguchi A, Bhan AK. A case for regulator y B cells. J Immun, 2006,176(2):705-10. 3 Yang M, Rui K, Wang SG, et al . Regulatory B cells in autoimmune diseases. Cell Mol Immun, 2013, 10(13):122-32 4 Wolf SD, Dittel BN, Hardardottir F, et al . Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice. J Exp Med

Open access