therapies resulting in longer survival.
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Veeramuthu Dharanishanthi and Modhumita Ghosh Dasgupta
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decreased expression of major histocompatibility complex (MHC) II antigens, which in turn impairs the function of T-lymphocytes [ 20 ]. This process is associated with decreased activity of NK-κB signaling pathway [ 8 ].
VEGF significantly regulates proliferation and migration of EC. By recruiting HSC and endothelial progenitor cells VEGF regulates microvessels development in the bone marrow niche and fundamentally affects hematopoiesis [ 15 , 21 ].
ANGPT1 and ANGPT2
Apart from VEGF, angiopoietin 1 (ANGPT1) and angiopoietin 2 (ANGPT2), both binding to receptor
Samia Abd El-Moneim Ebied, Nadia Aly Sadek, Nadia El-Sayed Zaki, Samir Ali Abd El- Kaream and Heba Khafagui Ahmed El Kashif
accumulation of blast cells in the bone marrow and peripheral blood [ 12 ]. Acute lymphoblastic leukemia (ALL) is a malignant disease characterized by the accumulation of lymphoblasts and it may be B or T lineages and the first attempt at classifying ALL was the French-American-British (FAB) morphological criteria that divided ALL into 3 subtypes (L1, L2 and L3) based on cell size, cytoplasm, nucleoli, vacuolation and basophilia. In 1997, the World Health Organization proposed a composite classification in an attempt to account for morphology and cytogenetic profile of the