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Histamine H4 receptor

a Novel Drug Target For Immunoregulation and Inflammation

Holger Stark

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Lamija Zecevic, Jasenko Karamehic, Jozo Coric, David Stubljar, Nesina Avdagic, Kenan Selmanovic, Tomislav Jukic and Sinisa Savic

Activity Index SLICC, Systemic Lupus International Collaborating Clinics SPE, specificity TCR, T-cell receptor Treg, T regulatory cells References 1. D’Cruz DP, Khamashta MA, Hughes GR. Systemic lupus erythematosus. Lancet 2007; 369 (9561): 587–96. 2. Choi J, Kim ST, Craft J. The pathogenesis of systemic lupus erythematosus: an update. Curr Opin Immunol 2012; 24: 651–7. 3. Castro C, Gourley M. Diagnostic testing and interpretation of tests for autoimmunity. J Allergy Clin Immunol 2010; 125: 238–47. 4. Tomioka R, Tani K, Sato K

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Jerzy Kawiak, Grazyna Hoser and Joanna Domagała-Kulawik

, Scagliotti GV. First-line therapeutic options for advanced non-small-cell lung cancer in the molecular medicine era. Future Oncol 2014; 10(6): 1081-1093. [12] Caramalho I, Nunes-Cabaco H, Foxall RB, Sousa AE. Regulatory T-Cell Development in the Human Thymus. Front Immunol 2015; 6: 395. [13] Martins VC, Busch K, Juraeva D, Blum C, Ludwig C, Rasche V, Lasitschka F, Mastitsky SE, Brors B, Hielscher T, Fehling HJ, Rodewald HR. Cell competition is a tumour suppressor mechanism in the thymus. Nature. 2014 May22; 509(7501): 465

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Jerzy Kawiak, Grazyna Hoser and Joanna Domagała-Kulawik

bronchoalveolar lavage fluid from patients with primary lung cancer. Arch. Immunol Ther.Exp.(Warsz.) 2006; 54: 143-147 [16] Domagala-Kulawik J, Maskey-Warzecowska M. T-regulatory cells in COPD or tumour environment. Eur.Respir.J. 2009; 34: 284-286 [17] Domagala-Kulawik J, Osinska I. [Immune alterations in lung cancer - the new therapeutic approach]. Pneumonol.Alergol.Pol. 2014; 82: 286-299 [18] Domagala-Kulawik J, Osinska I, Hoser G. Mechanisms of immune response regulation in lung cancer. Transl.Lung Cancer Res. 2014; 3: 15

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Mariusz J. Nawrocki, Joanna Budna, Piotr Celichowski, Ronza Khozmi, Artur Bryja, Wiesława Kranc, Sylwia Borys, Sylwia Ciesiółka, Sandra Knap, Michal Jeseta, Dorota Bukowska, Paweł Antosik, Klaus P. Brüssow, Małgorzata Bruska, Michał Nowicki, Maciej Zabel and Bartosz Kempisty

J Gynaecol Oncol. 2014;35(5):519-24. 12. Suh DH, Kim MA, Kim H, Kim MK, Kim HS, Chung HH, Kim YB, Song YS. Association of overexpression of hexokinase II with chemoresistance in epithelial ovarian cancer. Clin Exp Med. 2014;14(3):345-53. 13. Wang Y, Yun Y, Wu B, Wen L, Wen M, Yang H, Zhao L, Liu W, Huang S, Wen N, Li Y. FOXM1 promotes reprogramming of glucose metabolism in epithelial ovarian cancer cells via activation of GLUT1 and HK2 transcription. Oncotarget. 2016;7(30):47985-47997. 14. Okar DA, Wu C, Lange AJ. Regulation of the regulatory

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Malgorzata Krzyzowska, Weronika Swiatek, Beata Fijalkowska, Marek Niemialtowski and Ada Schollenberger

, UDONO H, YUI K. Regulation of the maintenance of peripheral T-cell anergy by TAB1-mediated p38-alpha activation. Mol Cell Biol 2004; 24: 6957-6966. [43] ORTEGA-PEREZ I, CANO E, WERE F, VILLAR M, VAZQUEZ J, REDONDO JM. c-Jun Nterminal kinase (JNK) positively regulates NFATc2 transactivation through phosphorylation within the N-terminal regulatory domain. J Biol Chem 2005; 28: 20867-20878. [44] PAN ZK. Toll-like receptors and TLR-mediated signaling: more questions than answers. Am J Physiol Lung Cell Mol Physiol 2004; 286: L918-L920

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Wiesława Kranc, Maurycy Jankowski, Joanna Budna, Piotr Celichowski, Ronza Khozmi, Artur Bryja, Sylwia Borys, Marta Dyszkiewicz-Konwińska, Michal Jeseta, Magdalena Magas, Dorota Bukowska, Paweł Antosik, Klaus P. Brüssow, Małgorzata Bruska, Michał Nowicki, Maciej Zabel and Bartosz Kempisty

. 1988. 15. Murray, S. C. and Smith, T. T., “Sperm interaction with fallopian tube apical membrane enhances sperm motility and delays capacitation,” Fertil. Steril. , vol. 68, no. 2, pp. 351-357, Aug. 1997. 16. Joshi, M. S., “Isolation, cell culture, and characterization of oviduct epithelial cells of the cow,” Microsc. Res. Tech. , vol. 31, no. 6, pp. 507-518, Aug. 1995. 17. Joshi, M. S., “Isolation, cell culture and immunocytochemical characterization of oviduct epithelial cells of the cow.,” J. Reprod. Fertil. , vol. 83, no. 1, pp. 249-61, May

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Dorota Kostrzewa-Nowak, Rafał Buryta and Robert Nowak

-induced muscle damage that can result in a release of inflammatory signalling molecules and myocellular enzymes into the blood plasma ( 9 , 10 , 11 , 12 ). Some of the most important components of the immune system are B and T lymphocytes. A number of T cell subsets, e.g. T naïve, T memory, T helper/inducer (Th), T suppressor/cytotoxic (Tc), T regulatory (Treg) has been described. A common feature of these cells is an expression of membrane surface receptors including T-cell receptor (TCR), CD3 and CD2. Taking the functionality into account, the Th (CD4 + ) cells are

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İbrahim Halil Demirsoy, Duygu Yolal Ertural, Şenay Balci, Ümit Çınkır, Kerem Sezer, Lülüfer Tamer and Nurcan Aras

beginning. Cancer Discov 2012; 2: 778–90. 16. Foretz M, Guigas B, Bertrand L, Pollak M, Viollet B. Metformin: from mechanisms of action to therapies. Cell Metab 2014; 20: 953–66. 17. Yu JW et al. Metformin improves the angiogenic functions of endothelial progenitor cells via activating AMPK/eNOS pathway in diabetic mice. Cardiovasc Diabetol 2016; 15: 88. 18. Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009; 136: 215–33. 19. Pillai RS, Bhattacharyya SN et al. Repression of protein synthesis by miRNAs: how many mechanisms

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Snežana Kojić

progenitor cells and cardiomyocytes. J Biol Chem 1997; 272: 22800-8. Aihara Y, Kurabayashi M, Saito Y, Ohyama Y, Tanaka T, Takeda S, et al. Cardiac ankyrin repeat protein is a novel marker of cardiac hypertrophy: role of M-CAT element within the promoter. Hypertension 2000; 36: 48-53. Baumeister A, Arber S, Caroni P. Accumulation of muscle ankyrin repeat protein transcript reveals local activation of primary myotube endcompartments during muscle morphogenesis. J Cell Biol 1997; 139: 1231