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. 69 (5), pp. 1051– 1064, 2018. [57] X. Mao, “OsPRX2 contributes to stomatal closure and improves potassium deficiency tolerance in rice,” Biochem. Biophys. Res. Commun., vol. 495 (1), pp. 461–467, 2018. [58] T. Wang, J.J. Wei, D.M. Sabatini, and E.S. Lander, “Genetic screens in human cells using the CRISPR-Cas9 system,” Science, vol. 343 (6166), pp. 80–84, 2014. [59] J. Gil-Humanes, “High-efficiency gene targeting in hexaploid wheat using DNA replicons and CRISPR/Cas9,” Plant J., vol. 89 (6), pp. 1251–1262, 2017. [60] D. Kim, B. Alptekin, and H. Budak, “CRISPR/Cas9

neurodegeneration and neuroinfl ammation in the A53T transgenic mouse model of Parkinson’s Disease. Cell Death Dis. 2018;9(7):725. https://doi.org/10.1038/s41419-018-0775-7 32. Gao HM, Zhang F, Zhou H, Kam W, Wilson B, Hong JS. Neuroinfl ammation and alpha-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson’s disease. Environ Health Perspect. 2011;119(6):807–14. https://doi.org/10.1289/ehp.1003013 33. Wu Q, Yang X, Zhang Y, Zhang L, Feng L. Chronic mild stress accelerates the progression of Parkinson

deep brain stimulation of the globus pallidus which may be a promising method to treat self-mutilating behavior and dystonia associated with LND [ 104 , 105 , 106 , 107 ]. Attempts to develop gene therapy have also been made [ 108 ] but could not be applied in patients. An enzyme replacement approach by TAT transduction domain and by liposome mediated protein transfer into HPRT deficient leukemia T-cells (CEM/HPRT) was also reported in an in vitro study [ 109 ]. Conclusion The present review aimed to highlight the great deal of research moved by LND, a rare