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References 1. Tsao BP. Update on human systemic lupus erythematosus genetics. Curr Opin Rheumatol. 2004; 16:513-21. 10.1097/01.bor.0000132648.62680.81 2. Zhang H, Yang P, Zhou H, Meng Q, Huang X: Involvement of Foxp3-expressing CD4+ CD25+ regulatory T cells in the development of tolerance induced by transforming growth factor-beta2-treated antigen-presenting cells. Immunology. 2008; 124: 304-14. 3. Namba K, Kitaichi N, Nishida T, Taylor AW. Induction of regulatory T cells by the immunomodulating cytokines alpha-melanocyte-stimulating hormone and transforming

:837-845. 10.1095/biolreprod.103.021147 21. Bendall SC, Stewart MH, Menendez P, George D, Vijayaragavan K, Werbowetski-Ogilvie T, et al. IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro. Nature. 2007; 448:1015-21. 22. Lei T, Jacob S, Ajil-Zaraa I, Dubuisson JB, Irion O, Jaconi M, Feki A. Xeno-free derivation and culture of human embryonic stem cells: current status, problems and challenges. Cell Res. 2007; 17:682-8. 10.1038/cr.2007.61 23. Swistowski A, Peng J, Han Y, Swistowska AM, Rao MS, Zeng X. Xeno-free defined

References 1. Calderwood SK, Mambula SS, Gray PJ Jr. Extracellular heat shock proteins in cell signaling and immunity. Ann NY Acad Sci. 2007; 1113:28-39. 2. V, Hauet-Broere F, Berlo S, Paul L, van der Zee R, de Kleer I,et al. Stress proteins as inducers and targets of regulatory T cells in arthritis. Int Rev Immunol. 2005; 24:181-97. 10.1080/08830180590934958 3. Pockley AG, Muthana M, Calderwood SK. The dual immunoregulatory roles of stress proteins. Trends Biochem Sci. 2008; 33:71-9. 4. Gupta RS, Ramachandra NB, Bowes T, Singh B. Unusual cellular disposition of

Genet. 1995; 11:101-5. 10.1016/S0168-9525(00)89010-1 5. Hall PA, Meek D, Lane DP. p53-integrating the complexity. J Pathol. 1996; 180:1-5. 10.1002/(SICI)1096-9896(199609)180:1<1::AID-PATH712>3.0.CO;2-U 6. Miyashita T, Krajewski S, Krajewska M, Wang HG, Lin HK, Liebermann DA, et al. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene. 1994; 9:1799-805. 7. Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/CDK4. Nature. 1993; 366:704-7. 8. Mork J, Lie AK

References 1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ. Cancer statistics, 2008. CA Cancer J Clin. 2008; 58: 71-96. 2. Mizukami Y, Kono K, Kawaguchi Y, Akaike H, Kamimura K, Sugai H, Fujii H. CCL17 and CCL22 chemokines within tumor microenvironment are related to accumulation of Foxp3+ regulatory T cells in gastric cancer. Int J Cancer. 2008; 122:2286-93. 3. Panani AD. Cytogenetic and molecular aspects of gastric cancer: clinical implications. Cancer Lett. 2008; 266:99-115. 4. Quezada SA, Jarvinen LZ, Lind EF, Noelle RJ. CD40/ CD154 interactions

-206. 12. Impey S, McCorkle SR, Cha-Molstad H, Dwyer JM, Yochum GS. Defining the CREB regulon: a genomewide analysis of transcription factor regulatory regions. Cell. 2004; 119:1041-54. 13. Maiese K, Chong ZZ, Shang YC. OutFOXOing disease and disability: The therapeutic potential of targeting FoxO proteins. Trends Mol Med. 2008; 14:219-27. 14. Guo S, Rena G, Cichy S, He X, Cohen P, Unterman T. Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity

] that GFAP was detected in NPCs derived from hESCs using a feeder-free method. Human neural stem cells isolated from fetal neural tissue also express low levels of GFAP mRNA and little or no S100β [ 46 ]. By contrast, the expression of TLX, also known as NR2E1, was significantly low in feeder-free derived NPCs that exhibited a high level of expression of GFAP when compared with NPCs derived by the EB method. TLX is an orphan nuclear receptor that plays an essential regulatory role in maintaining an undifferentiated state, proliferation, and suppresses astrocyte

, Feokistov I, Denenberg A, et al. The A2A receptor mediates an endogenous regulatory pathway of cytokine expression in THP-1 cells. J Leukoc Biol. 2002; 72: 1027-37. 35. Minguest S, Huber M, Rosenkranz L, Schamel WA, Reth M, Brummer T. Adenosine and cAMP are potent inhibitors of the NF-κB pathway downstream of immunoreceptors. Eur J Immunol. 2005; 35:31-41. 10.1002/eji.200425524 36. Lukashev D, Ohta A, Apasov S, Chen JF, Sitkovsky M. Cutting edge: physiologic attenuation of proinflammatory transcription by the Gs protein-coupled A2A adenosine receptor in vivo. J Immunol

differentiation. Biol Reprod. 2010; 83: 488-501. 10.1095/biolreprod.109.082685 11. Cherradi N, Rossier MF, Vallotton MB, Timberg R, Friedberg I, Orly J, et al. Submitochondrial distribution of three key steroidogenic proteins (steroidogenic acute regulatory protein and cytochrome P450scc and 3β-hydroxysteroid dehydrogenase isomerase enzymes) upon stimulation by intracellular calcium in adrenal glomerulosa cells. J Biol Chem. 1997; 272: 7899-907. 12. Stocco DM. Recent advances in the role of StAR. Rev Reprod. 1998; 3:82-5. 10.1530/ror.0.0030082 13. Walsh LP, Webster DR, Stocco

:908-13. 5. Lad C, Williams NH, Wolfenden R. The rate of hydrolysis of phosphomonoester dianions and the exceptional catalytic proficiencies of protein and inositol phosphatases. Proc Natl Acad Sci USA. 2003; 100:5607-10. 6. Virshup DM. Protein phosphatase 2A: a panoply of enzymes. Curr Opin Cell Biol. 2000; 12:180-5. 10.1016/S0955-0674(99)00074-5 7. Eichhorn PJ, Creyghton MP, Bernards R. Protein phosphatase 2A regulatory subunits and cancer. Biochim Biophys Acta. 2009; 1795:1-15. 8. Nakada N, Kuroda K, Kawahara E. Protein phosphatase 2A regulatory subunit Bbeta promotes