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deep brain stimulation of the globus pallidus which may be a promising method to treat self-mutilating behavior and dystonia associated with LND [ 104 , 105 , 106 , 107 ]. Attempts to develop gene therapy have also been made [ 108 ] but could not be applied in patients. An enzyme replacement approach by TAT transduction domain and by liposome mediated protein transfer into HPRT deficient leukemia T-cells (CEM/HPRT) was also reported in an in vitro study [ 109 ]. Conclusion The present review aimed to highlight the great deal of research moved by LND, a rare