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Application of mesenchymal stem cells in paediatrics

References 1. Ahn S.Y., Chang Y.S., Park W.S.: Mesenchymal stem cells transplantation for neuroprotection in preterm infants with severe intraventricular hemorrhage. Korean J Pediatr 57(6):251-6,2014. doi: 10.3345/kjp.2014.57.6.251. 2. Bajek A., Olkowska J., Drewa T.: Mesenchymal stem cells as a therapeutic tool in tissue and organ regeneration. Postepy Hig Med Dosw 24;65:124-32,2011. 3. Ball L.M., et al.: Multiple infusions of mesenchymal stromal cells induce sustained remission in children with steroid

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In vitro propagated Mentha rotundifolia (L.) Huds and antioxidant activity of its essential oil


Mentha rotundifolia (L.) Huds is an aromatic plant used for its medicinal values. This study aims to select appropriate conditions for in vitro propagation of M. rotundifolia (L.) Huds and to evaluate yield and antioxidants activity of its essential oils (EOs).

The explants were cultured on Murashige and Skoog (MS) medium containing different concentrations of growth regulators 6-benzylaminopurine (BAP) and Gibberellin (GA3).

Hydrodistillated EOs obtained from acclimatized and mother plant, were evaluated for their antioxidant activity. Tests were performed on DPPH free radical-scavenging, ABTS and CUPRAC assays.

Shoot induction and multiplication were successfully carried out on MS medium supplemented with the following hormones combinations: 1 mg/l BAP, 1 mg/l GA3 and 0.5 mg/l BAP, 0.5 mg/l GA3, respectively. Stem length, nodes and leaves number measured from development vitroplant were 6.89 cm, 5.22 nodes and 11.92 leaves per vitroplant, respectively.

In vitro rooted plants were successfully acclimatized at a temperature of 23 ± 2°C and a long day photoperiod with a total survival rate exceeding 95%.

EO yield of acclimated plant varied between (0.88-1.49 ml/100 g dry matter) compared to wild plant (0.73 ml/100 g dry matter). The antioxidant potential of EOs from acclimated plant showed on DPPH free radical-scavenging, ABTS and CUPRAC assays values of (IC50: 4.18-24.93 mg/ml), (IC50: 0.51-1.56 mg/ml) and (A0.50: 0.34-2.71 mg/ml), respectively. In contrast, the wild plant exhibited on the same tests the values of (IC50: 10.35 mg/ml), (IC50: 0.12 mg/ml) and (A0.50: 0.99 mg/ml), respectively.

The results suggest that micropropagation of M. rotundifolia (L.) Huds can be an interesting alternative for producing important plant material with the possibility to modulate EO yield and its antioxidant potential for future commercial purposes.

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A chemical activity evaluation of two dental calcium silicate-based materials

.: Effect of Biodentine™ on the proliferation, migration and adhesion of human dental pulp stem cells. J. Dent., 42, 490, 2014.

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Anti-Helicobacter pylori activity in vitro of chamomile flowers, coneflower herbs, peppermint leaves and thyme herbs – a preliminary report

of Algerian Thymus oils. Food Chem., 116, 714, 2009. 8. Lang G., Buchbauer G.: A review on recent research results (2008-2010) on essential oils as antimicrobial and antifungals. A review. Flavour Fragr. J., 27, 13, 2012. 9. Njume C. et al.: Volatile compounds in the stem bark of Sclerocarya birrea (Anacardiaceae) possess antimicrobial activity against drugresistant strains of Helicobacter pylori. Int. J. Antimicrob. Agents., 38, 319, 2011. 10. O`Donnell F. et al.: A study of the antimicrobial activity of selected

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Effects of technogenic pollutants on chicken embryos

(1): 1-23. 10. Fernandes R., Costola-Souza C., Sarmento C., Gonçalves L., Favaron Ph. O., Miglino M. A. Placental tissues as sources of stem cells. Open Journal of Animal Sciences. 2012; 2: 166-173. 11. Guedes P., Oliveira B., Manso P., Caputo L., Cotta-Pereira G., Pelajo-Machado M. Histological analyses demonstrate the temporary contribution of yolk sac, liver, and bone marrow to hematopoiesis during chicken development. PLoS One. 2014; 9(3). 12. Lavrinenko V.E., Zinabadinova S.S., Shobat L.B., Sokurenko L.M., Chaikovsky Yu.B. Influence of

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In vitro evaluation of anticancer activity of sodium hyaluronate-titanium dioxide bionanocomposite

HR, Payandeh M, Ramezani M, Sadeghi M, Mahmoudiahmadabadi M, Sharifi R. Efficacy of palifermin on oral mucositis and acute GVHD after hematopoietic stem cell transplantation (HSCT) in hematology malignancy patients: a meta-analysis of trials. Wspolczesna Onkol. 2017;21(4):299-305. 7. Parsa N. Environmental factors inducing human cancers. Iran J Public Health. 2012;41(11):1-9. 8. Brawley OW. Avoidable cancer deaths globally. CA Cancer J Clin. 2011;61(2):67-8. 9. Gopalan MR, Karunakaran V, Prabhakaran A, Jayakumar KL. Prevalence of psychiatric

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Systemic treatment of Krukenberg tumors

Hematol Oncol Stem Cell Res. 2014;8 (1):46-50. 4. Lama D, Ong E. The role of surgical excision for the Krukenberg tumour: A case report. Int J Surg Case Rep. 2017;38:185-188. doi: 10.1016/j.ijscr.2017.07.046. 5. Matsushita H, Watanabe K, Wakatsuki A. Metastatic gastric cancer to the female genital tract (Review). Mol Clin Oncol. 2016;5 (5):495-499. doi: 10.3892/mco.2016.1035. 6. Kumar M, Kumar A, Maroules M, Abrina V, Kumar V. Postmenopausal vaginal bleeding as initial presentation of gastric cancer: a case report with literature review of prognostic

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Furochinoline alkaloids in plants from Rutaceae family – a review

of alkaloids and coumarin from the stems of Conchocarpus fontanesianus, Braz. J. Pharmacogn. 22(2), 374-380, 2012. 7. Cardoso-Lopes E.M., Maier J.A., da Silva M.R. et al.: Alkaloids from stems of Esenbeckia leiocarpa Engl. (Rutaceae) as potential treatment for Alzheimer disease. Molecules, 15 (12), 9205-9213, 2010. 8. Cheng J.T., Chang T.K., Chen I.S.: Skimmianine and related furoquinolines function as antagonists of 5-hydroxytryptamine receptors in animals, J. Auton. Pharm., 14, 365-374, 1994. 9. Coulerie P., Maciuk

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Effect of compression pressure on mechanical and release properties of tramadol matrix tablets

. Ind. Pharm., 27, 935-42, 2001. 10. Haresh T.M., Bhumin P. and Nehal J.S.: Development of pH -independent matrix type sustained release drug delivery system of propranolol hydrochloride. J. Appl. Pharm. Sci., 1(3), 83-92, 2011. 11. Higuchi T.: Mechanism of sustained - action medication: Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm. Sci., 521, 145, 1963. 12. Ibrahim H., Rai P.P., Bangudu A. B.: Evaluation of mucilage from the stem bark of Cissus populnea. Afri. J. of Pharm

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Synthesis and anticancer properties of bacterial cellulose-magnesium oxide bionanocomposite

oral mucositis and acute GVHD after hematopoietic stem cell transplantation (HSCT) in hematology malignancy patients: a meta-analysis of trials. Wspolczesna Onkol . 2017;21(4):299-305. 12. Ma X, Yu H. Cancer issue: global burden of cancer. Yale J Biol Med . 2006;79(3-4):85-94. 13. Antoni S, Soerjomataram I, Moller B, Bray F, Ferlay J. An assessment of GLOBOCAN methods for deriving national estimates of cancer incidence. Bull World Health Organ . 2016; 94(3):174-84. 14. Benson JR, Jatoi I. The global breast cancer burden. Future Oncol . 2012

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