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András Mester, Diana Opincariu, Imre Benedek and István Benedek

REFERENCES 1. Boulton AJ, Vileikyte L, Ragnarson-Tennvall G, Apelqvist J. The global burden of diabetic foot disease. Lancet . 2005;366:1719-1724. 2. Rando TA. Stem cells, ageing and the quest for immortality. Nature . 2006;441:1080-1086. 3. Sen CK, Gordillo GM, Roy S, et al. Human skin wounds: a major and snowballing threat to public health and the economy. Wound Repair Regen . 2009;17:763-771. 4. Crovetti G, Martinelli G, Issi M, et al. Platelet gel for healing cutaneous chronic wounds. Transfus Apher Sci . 2004;30:145-151. 5

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István Benedek, Judit-Beáta Köpeczi, Enikő Kakucs, Szende Jakab, István Benedek and Erzsébet Lázár

References 1. Vonk AL, de Windt TS, Slaper-Cortenbach ICM, Saris DBF. Autologous, allogeneic, induced pluripotent stem cell or a combination stem cell therapy. Stem Cell Res Ther. 2015;6:94. 2. Kimbrel EA, Kouris NA, Yavanian GJ, et al. Mesenchymal stem cell population derived from human pluripotent stem cells displays potent immunomodulatory and therapeutic properties. Stem Cells Dev. 2014;23:1611-1624. 3. Isolex 300i Trening Manual, Version 2, Nexel Therapeutics Inc. USA, 2001, Section 2 4. McDonald-Hyman C, Turka LA, Blazar BR. Advances

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Mariann Gyöngyösi, Dominika Lukovic, Katrin Zlabinger, Ljubica Mandic, Johannes Winkler and Alfred Gugerell

failure. Circ Res. 2015;116:1361-1377. doi: https://doi.org/10.1161/CIRCRESAHA.116.304386 . 6. Fisher SA, Zhang H, Doree C, Mathur A, Martin-Rendon E. Stem cell treatment for acute myocardial infarction. Cochrane Database Syst Rev. 2015;9:CD006536. doi: 10.1002/14651858.CD006536.pub4. 7. Nowbar AN, Mielewczik M, Karavassilis M, et al. DAMASCENE writing group. Discrepancies in autologous bone marrow stem cell trials and enhancement of ejection fraction (DAMASCENE): weighted regression and meta-analysis. BMJ. 2014;348:g2688. doi: 10.1136/bmj.g2688. 8

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Diana Opincariu, András Mester, Imre Benedek and István Benedek

disease using stem and progenitor cell therapy. J Vasc Surg . 2011;53:445-453. 29. Botham CM, Bennett WL, Cooke JP. Clinical trials of adult stem cell therapy for peripheral artery disease. Methodist Debakey Cardiovasc J . 2013;9:201-205. 30. Hirota K, Semenza GL. Regulation of angiogenesis by hypoxiainducible factor 1. Crit Rev Oncol Hematol . 2006;59:15-26. 31. Voskuil M, van Royen N, Hoefer I, Buschmann I, Schaper W, Piek JJ. Angiogenesis and arteriogenesis; the long road from concept to clinical application. Ned Tijdschr Geneeskd . 2001

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Erzsébet Lázár, Lehel Bordi, István Benedek, Monica Chițu, Zsuzsanna Suciu, Tiberiu Nyulas, Roxana Hodas, Imre Benedek and István Benedek

REFERENCES 1. Finegold JA, Asaria P, Francis DP. Mortality from ischaemic heart disease by country, region, and age: statistics from World Health Organisation and United Nations. Int J Cardiol . 2013;168:934-945. 2. Lauer MS. Advancing cardiovascular research. Chest. 2012;141:500-505. 3. Bergmann O, Bhardwaj RD, Bernard S, et al. Evidence for cardiomyocyte renewal in humans. Science . 2009;324:98-102. 4. Segers VF, Lee RT. Stem-cell therapy for cardiac disease. Nature . 2008;451:937-942. 5. Asahara T, Kalka C, Isner JM. Stem cell

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András Mester, Balázs Oltean-Péter, Ioana Rodean, Diana Opincariu, Alexandra Stănescu, Erzsébet Lázár, István Benedek, Imre Benedek and István Benedek

clinical trials. J Am Coll Cardiol . 2008;21:956-964. 4. David G, David AB. MRI determination of myocardial viability. Appl Radiol . 2006;35. 5. Frangioni JV, Hajjar RJ. In vivo tracking of stem cells for clinical trials in cardiovascular disease. Circulation . 2004;110:3378-3383. 6. Chen IY, Wu JC. Cardiovascular molecular imaging: focus on clinical translation. Circulation . 2011;123:425-443. 7. Comella K, Griffeth J. Stem Cell Research in the Cardiac Field: Where Are We Now? World Stem Cell Report . 2009. 8. Krishna KA, Krishna KS

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István Benedek, Erzsébet Lázár, Judit Beáta Köpeczi, István Benedek, Aliz Beáta Tunyogi, Szende Jakab and Annamária Pakucs

. Karbasian Esfahani M, Morris EL, Dutcher JP, et al. Blastic phase of chronic myelogenous leukemia. Curr Treat Options Oncol . 2006;7:189-199. 6. Pavlu J, Szydlo RM, Goldman JM, Apperley JF. Three decades of transplantation for chronic myeloid leukemia: what have we learned? Blood . 2011;117:755-763. 7. Tunyogi AB, Benedek I, Benedek Lázár E, et al. The results of allogeneic stem cell transplantation in CML – the experience of BMT Unit Tîrgu Mureş. Acta Medica Marisiensis . 2011;57:371-374. 8. Gupta A, Khattry N. Current status of hematopoietic stem

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Annamária Pakucs, Erzsébet Lázár, Judit Beáta Köpeczi, Enikő Kakucs, István Benedek, Marius Găzdac, Eszter Mild, Cezara Tudor and István Benedek

REFERENCES 1. Hübel K, de la Rubbia J, Azar N, et al. Current status of haematopoietic autologous stem cell transplantation in lymphoid malignancies: a European perspective. Eur J Haematol . 2015;94:12-22. 2. Benekou K, Montoto S. Role of stem cell transplant in lymphoma in the era of new drugs. Curr Opin Oncol . 2017;29:455-459. 3. Chiappella A, Martelli M, Angelucci E, et al. Rituximab-dose-dense chemotherapy with or without high-dose chemotherapy plus autologous stem-cell transplantation in high-risk diffuse large B-cell lymphoma (DLCL04

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Cezara-Iuliana Tudor, Erzsébet Lázár, Marius-Vasile Găzdac, Annamária Pakucs, Eszter Mild, Judit-Beáta Köpeczi, Enikő Kakucs, István Benedek and István Benedek

to the Durie Salmon staging system? A comparison in multiple myeloma patients undergoing autologous transplant. Leukemia . 2009;23:1528-1534. 6. Greipp PR, San Miguel J, Durie BG, et al. International staging system for multiple myeloma. J Clin Oncol . 2005;23:3412-3420. 7. San Miguel JF, Bladé Creixenti J, García-Sanz R. Treatment of multiple myeloma. Haematologica . 1999;84:36-58. 8. Fermand JP, Ravaud P, Chevret S, et al. High-dose therapy and autologous peripheral blood stem cell transplantation in multiple myeloma: up-front or rescue

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Romulus Fabian Tatu, Mihai Hurmuz and Cătălin Adrian Miu

ligament graft. Knee Surg Sports Traumatol Arthrosc . 2008;16:224-231. 8. Claes S, Verdonk P, Forsyth R, Bellemans J. The “ligamentization” process in anterior cruciate ligament reconstruction: what happens to the human graft? A systematic review of the literature. Am J Sports Med . 2011;39:2476-2483. 9. Rizzello G, Longo UG, Petrillo S, et al. Growth Factors and Stem Cells for the Management of Anterior Cruciate Ligament Tears. Open Orthop J . 2012;6:525-530. 10. Bissell L, Tibrewal S, Sahni V, Khan WS. Growth factors and platelet rich plasma in