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Sebastian Giebel, Sylwia Oborska, Joanna Romejko-Jarosinska, Jarosław Dybko, Joanna Mańko, Joanna Sawczuk-Chabin, Agata Szymańska, Wojciech Legieć, Anna Czyż, Magdalena Maruszak, Maria Saduś-Wojciechowska, Joanna Drozd-Sokołowska, Paweł Steckiewicz, Anna Ejduk, Ewa Paszkiewicz-Kozik, Tomasz Ogórka, Michał Osowiecki, Łukasz Targoński and Michał Taszner

Background Autologous hematopoietic stem cell transplantation (autoHSCT) is widely applied for the treatment of patients with lymphoid malignancies [ 1 , 2 ]. Standard indications include multiple myeloma (MM), Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). While in MM autoHSCT is used as consolidation of first line treatment, for most of lymphoma subtypes it is considered after failure of initial chemotherapy. Currently, autoHSCT procedures are almost exclusively performed using peripheral blood as a source of stem cells, which requires successful

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Suleimman Al-Sweedan, Mona Alassiri, Ghaida Aljamal, Rafat Jafri, Amal Alseraihy and Khawar Siddiqui

Introduction Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal stem cell disorders, characterized by ineffective hematopoiesis, a variable degree of cytopenia, and an increased risk for developing acute myelogenous leukemia (AML) [1]. MDS with ≥ 2% blasts in PB or ≥ 5% but less than 20% blasts in the BM is classified as MDS-EB in the most recent WHO classification of myeloid neoplasms [ 2 ]. The variant MDS-EB in transformation (MDS-EB-t) is retained in the pediatric classification of MDS, [ 3 ] and is characterized by a PB or BM blast

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Jacques Brotchi

, Thibaut A, Brotchi J, Born J. Invading meningiomas of the sphenoid ridge. J Neurosurg. 1980;53(5):587-99. 7. Gaspard N, Bouschet T, Hourez R, Dimidschstein J, Naeije G, van den Ameele J, et al. An intrinsic mechanism of corticogenesis from embryonic stem cells. Nature. 2008;455(7211):351-7.

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Shigeaki Kobayashi and Akio Morita

References 1. Sano K. Pioneers in neurosurgery.Tokyo: Chugai-Igakusha Co; 1988. 2. Japan Neurosurgical Society . 60 years history of the Japan Neurosurgical Society .Japan: Yamada Planning Co Ltd; 2008. 3. Sasaki T, Hashiguchi K, Yoshimoto K, Nakamizo A, Mizoguchi M, Neurosurgical Staff of Kyushu U. Worldwide academic contributions of Japanese neurosurgeons. Neurol Med Chir (Tokyo). 2011;51(6):405-14. 4. Tabar V, Studer L. Pluripotent stem cells in regenerative medicine: challenges and recent

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Gerhard Franz Walter

the National Conference of Commissioners on Uniform State Laws, in cooperation with the American Medical Association, the American Bar Association, and the President’s Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research. By the definition of UDDA, an individual who has sustained either (1) irreversible cessation of circulatory and respiratory functions, or (2) irreversible cessation of all functions of the entire brain, including the brain stem (“whole brain” definition), is dead. A determination of death must be made in

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Mateusz Nowicki, Piotr Stelmach and Anna Szmigielska-Kapłon

proangiogenic cytokines and miRNAs correspond with the activity of new vessels development. In neoplastic disorders, angiogenesis takes part in the dissemination of cancer cells and progression of the disease. The other spectrum of interest is the evaluation of proangiogenic factors in the context of their influence on the regeneration of hematopoiesis after damage caused by high dose chemotherapy and stem cells transplantation [ 7 ]. Bone marrow niche is a unique microenvironment containing growth factors, accessory cells, extracellular matrix proteins and cell

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Monika Długosz-Danecka, Michał Szymczyk, Joanna Fischer, Anna Łojko-Dankowska, Justyna Rybka, Joanna Mańko, Katarzyna Duda and Wojciech Jurczak

Introduction Despite the effective frontline treatment of classical Hodgkin lymphoma (cHL), about 10% of early-stage and 30% of advanced stage patients experience disease relapse or have refractory disease [ 1 ]. Only half of relapsed/refractory (R/R) patients can be cured with salvage chemotherapy followed by high-dose chemotherapy (HDT) and autologous stem cell transplantation (ASCT) [ 2 ]. For patients relapsing after second-line treatment, the possible effective therapy option can be salvage treatment with novel agents that have emerged in recent years

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Samia Abd El-Moneim Ebied, Nadia Aly Sadek, Nadia El-Sayed Zaki, Samir Ali Abd El- Kaream and Heba Khafagui Ahmed El Kashif

binds to either Ang II-type 1 receptors (AGTR1) or Ang II-type 2 receptors (AGTR2). The AGTR1 and AGTR2 can act as antagonists, and mediate effects on cell migration and proliferation of metastatic cancer cells and hemopoietic stem-progenitor cells [ 7 ]. Components of the RAS are frequently differentially expressed in various cancers in comparison with their corresponding non-malignant tissue. In particular, over-expression of AGTR1 [ 3 ]. Studies of knockout mice for ACE as well as other RAS components such as angiotensinogen, renin, AGTR1 and AGTR2 have further

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Bembnista Ewa, Kubiak Agnieszka, Matuszak Paula and Kozłowska-Skrzypczak Maria

. Hematopoietic stem and progenitur cell harvesting: technical advances and clinical utility. J Blood Med. 2015; 6: 55–67. Hequet O. Hematopoietic stem and progenitur cell harvesting: technical advances and clinical utility J Blood Med. 2015 6 55 67 [2] Demiriz IS, Tekgunduz E, Altuntas F. What is the most appropriate source for hematopoietic stem cell transplantation? Peripheral stem cell/bone marrow/cord blood. Bone Marrow Research, 2012; 1-5 Demiriz IS Tekgunduz E Altuntas F. What is the most appropriate source for hematopoietic stem cell transplantation? Peripheral stem