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Winnie Wan-Yin Yeung and Chak-Sing Lau

1 Introduction Mesenchymal stem cell (MSC) is a multipotential nonhaematopoietic progenitor cell that is able to differentiate into various cell lineages. MSC can differentiate into osteoblasts, chondrocytes, myocytes, adipose tissues, endothelial cells, neuron-like cells, cardiomyocytes and hepatocytes. MSCs lack expression of co-stimulatory molecules, are capable of escaping from alloantigen recognition and, hence, have low immunogenicity. This is why MSCs are candidate cells to prevent rejection in transplant therapy and can be a potential treatment

Open access

Alina Tănase, C. Tomuleasa, Alexandra Mărculescu, A. Bardaş, Anca Coliţă and Ş.O. Ciurea

., COWAN C., DZIERZAK E., HACEIN-BEY-ABINA S., KARLSSON S., et al. Stem cell self-renewal: lessons from bone marrow, gut and iPS toward clinical applications. Leukemia. 2011; 25(7):1095-102. 5. SAULNIER N., DI CAMPLI C., ZOCCO M.A., DI GIOCCHINNO G., NOVI M., GASPARRINI A. From stem cell to solid organ. Bone marrow, peripheral blood or umbilical cord blood as favorable source? Eur Rev Med Pharmacol Sci. 2005; 9(6):315-24. 6. CANELLOS G.P., ANDERSSON J.R., PROPERT K.J., NISSE N., COOPER M.R., HENDERSSON E.S., et al. Chemotherapy of advanced

Open access

R.-G. Mihăilă

REFERENCES 1. TUNCER HH, RANA N, MILANI C, DARKO A, AL-HOMSI SA. Gastrointestinal and hepatic complications of hematopoietic stem cell transplantation. World J Gastroenterol. 2012; 18 : 1851-1860. 2. SCHOLL S, SAYER HG, MÜGGE LO, KASPER C, PIETRASZCZYK M, KLICHE KO, et al . Increase of interleukin-18 serum levels after engraftment correlates with acute graft-versus-host disease in allogeneic peripheral blood stem cell transplantation. J Cancer Res Clin Oncol. 2004; 130 : 704-710. 3. HEALTH QUALITY ONTARIO. Extracorporeal photophoresis

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C. Lucan, Laura-Ancuta Pop, A. Florian, Valentina Pileczki, B. Petrushev, Delia Dima, Ioana Frinc, Ioana Berindan-Neagoe, A. Irimie, C. Berce, I.-S. Florian, Anca Bojan and C. Tomuleasa

children . Clin Oncol (R Coll Radiol). 2014; 26 (7):438-45. 5. CHEUK DK., LEE TL., CHIANG AK., HA SY., CHAN GC. Autologous hematopoietic stem cell transplantation for high-risk brain tumors in children . J Neurooncol. 2008; 86 (3):337-47. 6. SANDU N., SCHALLER B. Stem cell transplantation in brain tumors: a new field for molecular imaging? Mol Med. 2010; 16 (9-10):433-7. 7. COHEN AL., COLMAN H. Glioma biology and molecular markers . Cancer Treat Res. 2015; 163 :15-30. 8. WURDINGER T., DEUMELANDT K., VAN DER VLIET HJ., WESSELING P., DE

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L.M. Predescu, L. Zarma, P. Platon, M. Postu, A. Bucsa, M. Croitoru, B. Prodan, O. Chioncel and D. Delean

Cardiovascular manifestations of tertiary syphilis infections are uncommon, but represent an important cause of mortality and morbidity. Syphilitic aortitis is characterized by aortic regurgitation, dilatation of ascending aorta and ostial coronary artery lesions.

We report a case of 36 years old man admitted to our hospital for acute anterior ST segment elevation myocardial infarction complicated with cardiogenic shock (hypotension 75/50 mmHg). Transthoracic echocardiography revealed a dilated left ventricle with severe systolic dysfunction (ejection fraction = 25%), severe mitral regurgitation, moderate aortic regurgitation and mildly dilated ascending aorta. Coronary angiography showed a severe ostial lesion of left main coronary artery which was treated by urgent stent implantation and an intra-aortic contrapulsation balloon was implanted. Blood tests for syphilitic infection were positive. The patient was discharged with treatment including benzathine penicillin.

In our case, we present an acute manifestation of a syphilitic ostial left main stenosis treated by primary percutaneous coronary intervention in acute myocardial infarction. Long term follow-up of the patient is crucial as a result of potential rapid in-stent restenosis caused by continuous infection of the ascending aorta.

This case is particular because it shows that syphilitic aortitis can be diagnosed in acute settings, like ST segment elevation myocardial infarction.

Open access

Suleyman Baldane, Serdar Sivgin, Leylagul Kaynar, Ersin Ozaslan, Afra Yildirim, Ozlem Canoz and Bulent Eser


A 42-year-old male patient was admitted to our hospital for planning autologous hematopoietic stem cell transplantation (auto-HSCT). He was diagnosed as multiple myeloma (IgG type Kappa) in 2003. His physical examination was normal with no important abnormality on laboratory evaluation. Chest radiography performed for routine evaluation prior to transplantation revealed a large, well-defined mass, that had obtuse angles with the chest wall consistent with extraparenchymal lesion superposed on second and third ribs. Also, there were multiple bony structures demonstrating changes of destructive effects of multiple myeloma. Computed tomography (CT)-guided biopsy was obtained from the mass by transthoracic fine-needle aspiration (FNAB) method. Biopsy was reported as extramedullary hematopoiesis (EMH) contrary to our expectation of multiple myeloma.

Open access

Anca Bojan, Ioana Berindan-Neagoe, S. Ciurea, Delia Dima, Shigeo Fuji, G. Ghiaur, Ravnit Grewal, Emmet Mccormack, Alina Tanase, A. Trifa and Ciprian Tomuleasa

References 1. THE LANCET HAEMATOLOGY. A roadmap for European research. Lancet Haematol. 2016; 3(3):e99. 2. TOMULEASA C., FUJI S., CUCUIANU A., KAPP M., PILECZKI V., PETRUSHEV B., et al. MicroRNAs as biomarkers for graft-versus-host disease following allogeneic stem cell transplantation. Ann Hematol. 2015; 94(7):1081-92. 3. BRAICU C., TOMULEASA C., MONROIG P., CUCUIANU A., BERINDAN-NEAGOE I., CALIN G.A. Exosomes as divine messengers: are they the Hermes of modern molecular oncology? Cell Death Differ. 2015; 22

Open access

Gianina Viorica Micu, Florica Stăniceanu, Liana Cătălina Sticlaru, Cristiana Gabriela Popp, Alexandra Eugenia Bastian, Eliza Gramada, G. Pop., R. B. Mateescu, M. Rimbaş, Bianca Archip and Coralia Bleotu

REFERENCES 1. YANG L. et al . Cancer stem cells biomarkers in gastric carcinogenesis . J. Gastrointestin Canc. 2013; 44 :428-435. 2. LAZĂR D. et al . Tumor angiogenesis in gastric cancer . Rom. J. Morphol. Embryol. 2006; 47 :5-13. 3. RIBATTI D. et al . Mast cells and angiogenesis in gastric carcinoma . Int. J. Exp. Pathol. 2010; 91 :350-356. 4. AMMENDOLA M. Infiltrating mast cells correlate with angiogenesis in bone metastases from gastric cancer patients . Int. J. Mol. Sci. 2015; 16 :3237-3250. 5. YU JX, ZHANG XT, LIAO YQ

Open access

Ioana Frinc, Petru Ilies, Florin Zaharie, Delia Dima, Alina Tanase, Ljubomir Petrov, Alexandru Irimie, Cristian Berce, Cosmin Lisencu, Ioana Berindan-Neagoe, Ciprian Tomuleasa and Anca Bojan

REFERENCES 1. TANASE A., TOMULEASA C., MARCULESCU A., BARDAS A., COLITA A, ORBAN C., et al ., Haploidentical donors: can faster transplantation be life-saving for patients with advanceddisease? Acta Haematol. 2016; 135(4):211-6. 2. BRAMMER J.E., KHOURI I., GABALLA S., ANDERLINI P., TOMULEASA C., AHMED S., et al ., Outcomes of haploidentical stem cell transplantation for lymphoma with melphalan-based conditioning . Biol Blood Marrow Transplant. 2016; 22(3):493-8. 3. PAGANO L., CAIRA M., CANDONI A., OFFIDANI M., FIANCHI L., MARTINO B., et al

Open access

Evelyn Nathalia, Madelaine Skolastika Theardy, Sharleen Elvira, Graciella Rosellinny, Andrew Steven Liyanto, Michael Putra Utama and Anton Sumarpo

results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum . Development. 1999; 126 (15):3359–3370. 9. SANDBERG M., FLANDIN P., SILBERBERG S., SU-FEHER L., PRICE JD., HU JS., et al. Transcriptional networks controlled by NKX2-1 in the development of forebrain GABAergic neurons . Neuron. 2016; 91 (6):1260–1275. 10. KIM TG., YAO R., MONNELL T., CHO JH., VASUDEVAN A., KOH A., et al. Efficient specification of interneurons from human pluripotent stem cells by