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Autologiczna transplantacja komórek krwiotwórczych u chorych na szpiczaka plazmocytowego w dobie nowych terapii

Wprowadzenie Szpiczak plazmocytowy ( multiple myeloma – MM), nowotworowy rozrost komórek plazmatycznych, należy do najczęstszych nowotworów hematologicznych i stanowi przy tym najczęstsze wskazanie do autologicznej transplantacji komórek krwiotwórczych ( autologous hematopoietic stem cell transplantation – AHSCT) [ 1 , 2 , 3 ]. Wprowadzenie do terapii wysokodozowanego melfalanu z następowym przeszczepieniem komórek krwiotwórczych w istotny sposób wpłynęło na wydłużenie życia chorych na MM. Dalszą poprawę przeżycia umożliwiło zastosowanie takich nowych

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Plerixafor for patients who fail cytokine-or chemotherapy-based stem cell mobilization: Results of a prospective study by the Polish Lymphoma Research Group (PLRG)

Background Autologous hematopoietic stem cell transplantation (autoHSCT) is widely applied for the treatment of patients with lymphoid malignancies [ 1 , 2 ]. Standard indications include multiple myeloma (MM), Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). While in MM autoHSCT is used as consolidation of first line treatment, for most of lymphoma subtypes it is considered after failure of initial chemotherapy. Currently, autoHSCT procedures are almost exclusively performed using peripheral blood as a source of stem cells, which requires successful

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ABC of viral infections in hematology: focus on herpesviruses

thrombotic microangiopathy in SCID patients, as well as encephalitis post-HCT. Risk factors and incidence of reactivation Risk factors of herpes virus recurrence after allo-HCT depend on the following: recipient (virus serology; age), donor (virus serology match; age; sex match; HLA match; type of family/unrelated donor; stem cell source), transplant (type of conditioning: TBI-or chemotherapy-based; T-cell depletion; intensity of myeloablative or reduced intensity conditioning, RIC), immunosuppressive treatment (prophylaxis, occurrence and treatment of acute and

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Infectious complications in children and adults with hematological malignancies

Introduction: nationwide project Infections are the main cause of morbidity and mortality in patients with cancer or undergoing stem cell transplantation [ 1 ]. Children and adults with hematologic malignancies are especially susceptible to bacterial, fungal, and viral infections due to abnormality of the basic mediators of immunity. Factors that predispose these patients to infection include the following: alterations of the body’s natural barriers, presence of central venous catheters, alteration of the innate immune system and acquired immunity, as well as

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Chłoniak z komórek płaszcza – rola terapii celowanych

jest wtórnych zaburzeń cytogenetycznych [ 7 ]. To grupa chorych, których można do czasu progresji poddać obserwacji, a w razie potrzeby leczenia zastosować monoterapię rytuksymabem lub mało intensywną immunochemioterapię. U pozostałych chorych podstawowe znaczenie dla podjęcia decyzji o wyborze leczenia I linii ma możliwość poddania ich wysokodawkowanej chemioterapii z następowym autologicznym przeszczepieniem komórek macierzystych ( autologous stem cell transplantation – ASCT). Retrospektywna ocena Polskiej Grupy Badawczej Chłoniaków (Polish Lymphoma Research

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Diagnostyka gorączki u pacjentki z rozpoznaniem przewlekłej białaczki limfocytowej

Hodgkina szansą na długotrwałą remisję. Post Nauk Med 9;2012: 694–8. Krawczyk-Kuliś M Kopińska A Markiewicz M et al Alloprzeszczepienie komórek krwiotwórczych w opornych przypadkach chłoniaka Hodgkina szansą na długotrwałą remisję Post Nauk Med 9 2012 694 8 28 Friedberg J. Hodgkin lymphoma: answers take time! Blood 2011;117:5274–6. Friedberg J Hodgkin lymphoma: answers take time! Blood 2011 117 5274 6 29 Robinson S, Sureda A, Canals C, et al. Reduced intensity conditioning allogeneic stem cell transplantation for Hodgkin’s lymphoma

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Rzadkie postacie chłoniaków T-komórkowych – aktualne postępowanie

. How I treat breast implant-associated anaplastic large cell lymphoma. Blood 2018;132(18): 1889–1898. 10.1182/blood-2018-03-785972 Mehta-Shah N Clemens MW Horwitz SM How I treat breast implant-associated anaplastic large cell lymphoma Blood 2018 132 18 1889 1898 [14] Sieniawski M, Angamuthu N, Boyd K, et al. Evaluation of enteropathy-associated T-cell lymphoma comparing standard therapies with a novel regimen including autologous stem cell transplantation. Blood 2010;115(18):3664–70. 10.1182/blood-2009-07-231324 20197551 Sieniawski M

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Stem Cell Transplantation in Pediatric Patients with Myelodysplastic Syndrome at a Single Institution

Introduction Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal stem cell disorders, characterized by ineffective hematopoiesis, a variable degree of cytopenia, and an increased risk for developing acute myelogenous leukemia (AML) [1]. MDS with ≥ 2% blasts in PB or ≥ 5% but less than 20% blasts in the BM is classified as MDS-EB in the most recent WHO classification of myeloid neoplasms [ 2 ]. The variant MDS-EB in transformation (MDS-EB-t) is retained in the pediatric classification of MDS, [ 3 ] and is characterized by a PB or BM blast

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Selected factors influencing angiogenesis and hematopoietic niche

proangiogenic cytokines and miRNAs correspond with the activity of new vessels development. In neoplastic disorders, angiogenesis takes part in the dissemination of cancer cells and progression of the disease. The other spectrum of interest is the evaluation of proangiogenic factors in the context of their influence on the regeneration of hematopoiesis after damage caused by high dose chemotherapy and stem cells transplantation [ 7 ]. Bone marrow niche is a unique microenvironment containing growth factors, accessory cells, extracellular matrix proteins and cell

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